Skip to main content

Table 2 Summary of the results of prior studies in patients with anti-GBM disease between 2000 and 2020

From: Clinical and immunologic characteristics of Japanese patients with anti-glomerular basement membrane disease: case reports and literature review

Reference Country Study period (year) Sample size (n) Age (years) sCr (mg/dl) Anti-GBM measurement method eGFR (ml/min/1.73 m2) Lung involvement(%) Prednisolone (%) Cyclophosphamide (%) Plasmapheresis (%) Infectious complication (%) Relapse rate (%) 1-year survival (%) 5-year survival (%)
Levy et al. [7] UK 1975–1999 81 40 3.6 ELISA NA 62 100 100 100 NA 3 79 NA
Segelmark et al. [3] Sweden 1987–1995 79 59 NA ELISA NA 21 NA NA NA NA NA 66* NA
Li et al. [8] China 1992–2003 10 59 NA ELISA or IIF NA 80 80 80 80 0 0 80 NA
Rutgers et al. [9] Netherlands 1978–2003 24 57 9.9 ELISA NA NA 54 54 54 NA NA 91 NA
Hirayama et al. [5] Japan 1989–2000 47 51 7.5 NA NA 23 85 36 55 NA 14 67* NA
Kitagawa et al. [4] Japan 1995–2005 16 61 8.2 NA NA 25 NA NA NA NA NA 88 NA
Cui et al. [2] China 1998–2008 221 39 9.5 ELISA NA 46 80 34 76 NA NA 73 NA
Dammacco et al. [10] Italy 2003–2012 10 49 NA ELISA NA 60 100 100 100 NA 20 80 NA
Alchi et al. [11] UK 1991–2011 43 53 NA Radioimmunoassay NA 40 74 74 74 NA 0 88 NA
Huart et al. [12] France 1983–2006 122 31 7.2 ELISA NA 91 97 84 100 NA NA 87 NA
Canney et al. [13] Ireland 2003–2014 79 63 NA ELISA NA 98 NA NA NA NA NA 62 24
McAddo et al. [14] Czech, UK, and Sweden 2000–2013 78 61 3.3 ELISA or IIF 20§ 38 100 92 89 NA 0 86 NA
Marques et al. [15] France 1981–2017 119 54 7.2 ELISA NA 45 97 82 82 2 3 95 92
Caillard et al. [16] France 1997–2017 201 53 7.4 IIF and/or antigen-specific immunoassay NA 37 97 81 77 58 NA 92 79
Our case series Japan 2000–2020 12 70 8.5 ELISA 5 42 100 0 67 3 8 82 68
  1. The proportions combined the proportion of oral prednisolone and that of methylprednisolone pulse therapy
  2. GBM glomerular filtration rate, eGFR estimated glomerular filtration rate, ELISA enzyme-linked immunosorbent assay, NA not available, IIF indirect immunofluorescence, sCr serum creatinine level
  3. *6-month survival
  4. § The Modified Diet in Renal Disease equation was used