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Table 3 Comparison of patient background, total pill burden, number of patients, and pill burden from PBs between males and females and presence and absence of DM

From: Prescription characteristics of phosphate binders in a high pill burden for hemodialysis patients

  Total Gender (male) Gender (female)   non-DM DM  
533(100%) 362 (67.9%) 171 (32.1%) (P) 223 (41.8%) 310 (58.2%) (P)
Age years 71.3 (63.8-78.0) 70.4 (61.2-76.0) 73.3 (66.7-81.5) < 0.001 72.3 (64.4-79.4) 71.0 (63.0-76.2) 0.093
Diabetes (yes) n (%) 310 (58.2) 224 (61.9) 86 (50.3) 0.008
Dialysis vintage years 5.5 (2.1-10.8) 6.1 (2.1-11.4) 4.5 (2.2-9.1) 0.094 8.2 (2.9-17.1) 4.5 (1.8-7.7) < 0.001
Serum MBD parameters
 Corrected Ca mg/dL 8.70 ± 0.61 8.61 ± 0.62 8.88 ± 0.55 < 0.001 8.74 ± 0.63 8.67 ± 0.60 0.258
 P mg/dL 5.37 ± 1.17 5.42 ± 1.22 5.27 ± 1.04 0.174 5.51 ± 1.19 5.27 ± 1.14 0.019
 i-PTH pg/mL 182 (120-257) 189 (132-260) 168 (107-252) 0.091 182 (122-267) 183 (117-256) 0.596
Nutritional status
 Serum Alb g/dL 3.78 ± 0.33 3.81 ± 0.33 3.72 ± 0.33 0.002 3.79 ± 0.33 3.78 ± 0.34 0.913
 nPCR g/kg/day 0.772 ± 0.139 0.758 ± 0.132 0.800 ± 0.150 0.001 0.795 ± 0.137 0.755 ±0.139 0.003
Total pill burden (mean) pills/day/patient 15.1± 7.6 15.6 ± 7.8 13.9 ± 7.1 0.006 14.9 ± 7.7 15.2 ± 7.5 0.520
Total pill burden (median) pills/day/patient 14.1 (10.0-18.7) 14.8 (10.5-19.7) 12.9 (8.8-16.8) 0.006 13.9 (9.6-18.9) 14.2 (10.4-18.6) 0.520
Number of patients
 All PBs n (%) 409 (76.7) 279 (77.1) 130 (76.0) 0.435 178 (79.8) 231 (74.5) 0.092
 Individual PBs
  Ca carbonate n (%) 301 (56.5) 207 (57.2) 94 (55.0) 0.349 133 (59.6) 168 (54.2) 0.122
  La carbonate n (%) 164 (30.8) 124 (34.3) 40 (23.4) 0.007 81 (36.3) 83 (26.8) 0.012
  Fe-based PBs n (%) 104 (19.5) 75 (20.7) 29 (17.0) 0.183 38 (17.0) 66 (21.3) 0.133
  Polymeric PBs n (%) 39 (7.3) 28 (7.7) 11 (6.4) 0.365 16 (7.2) 23 (7.4) 0.528
Pill burden from PBs
 All PBs pills/day/patient 6.44 ±4.78 6.94 ± 5.08 5.36 ± 3.87 0.002 6.92 ± 4.94 6.08 ± 4.64 0.038
 Individual PBs
  Ca carbonate pills/day/patient 4.36 ± 2.01 4.47 ± 2.11 4.12 ± 1.77 0.298 4.64 ± 2.04 4.15 ± 1.97 0.035
  La carbonate pills/day/patient 3.98 ± 2.14 4.09 ± 2.17 3.64 ± 2.03 0.190 4.25 ± 2.28 3.72 ± 1.97 0.103
  Fe-based PBs pills/day/patient 4.14 ± 2.40 4.40 ± 2.53 3.47 ± 1.93 0.066 4.22 ± 3.17 4.09 ± 1.85 0.511
  Polymeric PBs pills/day/patient 6.10 ± 3.34 6.23 ± 3.45 5.77 ± 3.20 0.633 6.88 ± 3.23 5.56 ± 3.38 0.301