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Table 3 Comparison of patient background, total pill burden, number of patients, and pill burden from PBs between males and females and presence and absence of DM

From: Prescription characteristics of phosphate binders in a high pill burden for hemodialysis patients

 

Total

Gender (male)

Gender (female)

 

non-DM

DM

 

533(100%)

362 (67.9%)

171 (32.1%)

(P)

223 (41.8%)

310 (58.2%)

(P)

Age

years

71.3 (63.8-78.0)

70.4 (61.2-76.0)

73.3 (66.7-81.5)

< 0.001

72.3 (64.4-79.4)

71.0 (63.0-76.2)

0.093

Diabetes (yes)

n (%)

310 (58.2)

224 (61.9)

86 (50.3)

0.008

Dialysis vintage

years

5.5 (2.1-10.8)

6.1 (2.1-11.4)

4.5 (2.2-9.1)

0.094

8.2 (2.9-17.1)

4.5 (1.8-7.7)

< 0.001

Serum MBD parameters

 Corrected Ca

mg/dL

8.70 ± 0.61

8.61 ± 0.62

8.88 ± 0.55

< 0.001

8.74 ± 0.63

8.67 ± 0.60

0.258

 P

mg/dL

5.37 ± 1.17

5.42 ± 1.22

5.27 ± 1.04

0.174

5.51 ± 1.19

5.27 ± 1.14

0.019

 i-PTH

pg/mL

182 (120-257)

189 (132-260)

168 (107-252)

0.091

182 (122-267)

183 (117-256)

0.596

Nutritional status

 Serum Alb

g/dL

3.78 ± 0.33

3.81 ± 0.33

3.72 ± 0.33

0.002

3.79 ± 0.33

3.78 ± 0.34

0.913

 nPCR

g/kg/day

0.772 ± 0.139

0.758 ± 0.132

0.800 ± 0.150

0.001

0.795 ± 0.137

0.755 ±0.139

0.003

Total pill burden (mean)

pills/day/patient

15.1± 7.6

15.6 ± 7.8

13.9 ± 7.1

0.006

14.9 ± 7.7

15.2 ± 7.5

0.520

Total pill burden (median)

pills/day/patient

14.1 (10.0-18.7)

14.8 (10.5-19.7)

12.9 (8.8-16.8)

0.006

13.9 (9.6-18.9)

14.2 (10.4-18.6)

0.520

Number of patients

 All PBs

n (%)

409 (76.7)

279 (77.1)

130 (76.0)

0.435

178 (79.8)

231 (74.5)

0.092

 Individual PBs

  Ca carbonate

n (%)

301 (56.5)

207 (57.2)

94 (55.0)

0.349

133 (59.6)

168 (54.2)

0.122

  La carbonate

n (%)

164 (30.8)

124 (34.3)

40 (23.4)

0.007

81 (36.3)

83 (26.8)

0.012

  Fe-based PBs

n (%)

104 (19.5)

75 (20.7)

29 (17.0)

0.183

38 (17.0)

66 (21.3)

0.133

  Polymeric PBs

n (%)

39 (7.3)

28 (7.7)

11 (6.4)

0.365

16 (7.2)

23 (7.4)

0.528

Pill burden from PBs

 All PBs

pills/day/patient

6.44 ±4.78

6.94 ± 5.08

5.36 ± 3.87

0.002

6.92 ± 4.94

6.08 ± 4.64

0.038

 Individual PBs

  Ca carbonate

pills/day/patient

4.36 ± 2.01

4.47 ± 2.11

4.12 ± 1.77

0.298

4.64 ± 2.04

4.15 ± 1.97

0.035

  La carbonate

pills/day/patient

3.98 ± 2.14

4.09 ± 2.17

3.64 ± 2.03

0.190

4.25 ± 2.28

3.72 ± 1.97

0.103

  Fe-based PBs

pills/day/patient

4.14 ± 2.40

4.40 ± 2.53

3.47 ± 1.93

0.066

4.22 ± 3.17

4.09 ± 1.85

0.511

  Polymeric PBs

pills/day/patient

6.10 ± 3.34

6.23 ± 3.45

5.77 ± 3.20

0.633

6.88 ± 3.23

5.56 ± 3.38

0.301