From: Prescription characteristics of phosphate binders in a high pill burden for hemodialysis patients
Total | Gender (male) | Gender (female) | non-DM | DM | ||||
---|---|---|---|---|---|---|---|---|
533(100%) | 362 (67.9%) | 171 (32.1%) | (P) | 223 (41.8%) | 310 (58.2%) | (P) | ||
Age | years | 71.3 (63.8-78.0) | 70.4 (61.2-76.0) | 73.3 (66.7-81.5) | < 0.001 | 72.3 (64.4-79.4) | 71.0 (63.0-76.2) | 0.093 |
Diabetes (yes) | n (%) | 310 (58.2) | 224 (61.9) | 86 (50.3) | 0.008 | ― | ― | ― |
Dialysis vintage | years | 5.5 (2.1-10.8) | 6.1 (2.1-11.4) | 4.5 (2.2-9.1) | 0.094 | 8.2 (2.9-17.1) | 4.5 (1.8-7.7) | < 0.001 |
Serum MBD parameters | ||||||||
Corrected Ca | mg/dL | 8.70 ± 0.61 | 8.61 ± 0.62 | 8.88 ± 0.55 | < 0.001 | 8.74 ± 0.63 | 8.67 ± 0.60 | 0.258 |
P | mg/dL | 5.37 ± 1.17 | 5.42 ± 1.22 | 5.27 ± 1.04 | 0.174 | 5.51 ± 1.19 | 5.27 ± 1.14 | 0.019 |
i-PTH | pg/mL | 182 (120-257) | 189 (132-260) | 168 (107-252) | 0.091 | 182 (122-267) | 183 (117-256) | 0.596 |
Nutritional status | ||||||||
Serum Alb | g/dL | 3.78 ± 0.33 | 3.81 ± 0.33 | 3.72 ± 0.33 | 0.002 | 3.79 ± 0.33 | 3.78 ± 0.34 | 0.913 |
nPCR | g/kg/day | 0.772 ± 0.139 | 0.758 ± 0.132 | 0.800 ± 0.150 | 0.001 | 0.795 ± 0.137 | 0.755 ±0.139 | 0.003 |
Total pill burden (mean) | pills/day/patient | 15.1± 7.6 | 15.6 ± 7.8 | 13.9 ± 7.1 | 0.006 | 14.9 ± 7.7 | 15.2 ± 7.5 | 0.520 |
Total pill burden (median) | pills/day/patient | 14.1 (10.0-18.7) | 14.8 (10.5-19.7) | 12.9 (8.8-16.8) | 0.006 | 13.9 (9.6-18.9) | 14.2 (10.4-18.6) | 0.520 |
Number of patients | ||||||||
All PBs | n (%) | 409 (76.7) | 279 (77.1) | 130 (76.0) | 0.435 | 178 (79.8) | 231 (74.5) | 0.092 |
Individual PBs | ||||||||
Ca carbonate | n (%) | 301 (56.5) | 207 (57.2) | 94 (55.0) | 0.349 | 133 (59.6) | 168 (54.2) | 0.122 |
La carbonate | n (%) | 164 (30.8) | 124 (34.3) | 40 (23.4) | 0.007 | 81 (36.3) | 83 (26.8) | 0.012 |
Fe-based PBs | n (%) | 104 (19.5) | 75 (20.7) | 29 (17.0) | 0.183 | 38 (17.0) | 66 (21.3) | 0.133 |
Polymeric PBs | n (%) | 39 (7.3) | 28 (7.7) | 11 (6.4) | 0.365 | 16 (7.2) | 23 (7.4) | 0.528 |
Pill burden from PBs | ||||||||
All PBs | pills/day/patient | 6.44 ±4.78 | 6.94 ± 5.08 | 5.36 ± 3.87 | 0.002 | 6.92 ± 4.94 | 6.08 ± 4.64 | 0.038 |
Individual PBs | ||||||||
Ca carbonate | pills/day/patient | 4.36 ± 2.01 | 4.47 ± 2.11 | 4.12 ± 1.77 | 0.298 | 4.64 ± 2.04 | 4.15 ± 1.97 | 0.035 |
La carbonate | pills/day/patient | 3.98 ± 2.14 | 4.09 ± 2.17 | 3.64 ± 2.03 | 0.190 | 4.25 ± 2.28 | 3.72 ± 1.97 | 0.103 |
Fe-based PBs | pills/day/patient | 4.14 ± 2.40 | 4.40 ± 2.53 | 3.47 ± 1.93 | 0.066 | 4.22 ± 3.17 | 4.09 ± 1.85 | 0.511 |
Polymeric PBs | pills/day/patient | 6.10 ± 3.34 | 6.23 ± 3.45 | 5.77 ± 3.20 | 0.633 | 6.88 ± 3.23 | 5.56 ± 3.38 | 0.301 |