Table 1 Baseline characteristics by ERI quartile
All | ERI quartiles | P for trend | ||||
|---|---|---|---|---|---|---|
Q1 (< 2.73) | Q2 (2.74–5.36) | Q3 (5.37–11.30) | Q4 (11.31 ≤) | |||
N | 127 | 32 | 31 | 32 | 32 | |
Age (years) | 67 (59–74) | 66.5 (51.3–71.0) | 62.0 (55.0–67.0) | 71.5 (66.3–80.8) | 69.5 (63.3–75.8) | < 0.001 |
Male gender (%) | 55.1 | 65.6 | 61.3 | 43.8 | 50.0 | 0.271 |
Dialysis duration (y) | 6.7 (2.8–12.3) | 6.5 (3.7–12.0) | 9.3 (3.7–13.3) | 7.0 (3.0–12.8) | 3.0 (1.8–10.3) | 0.140 |
Smoking (history) (%) | 44.1 | 43.8 | 54.8 | 37.5 | 40.6 | 0.537 |
History of cardiovascular disease (%) | 19.7 | 15.6 | 12.9 | 31.3 | 18.8 | 0.266 |
Body mass index (kg/m2) | 21.4 (19.0–23.7) | 23.1 (21.0–25.9) | 21.2 (19.9–23.1) | 20.8 (19.1–23.1) | 20.3 (17.7–22.6) | 0.006 |
Diabetes (%) | 44.9 | 43.8 | 41.9 | 50.0 | 43.8 | 0.923 |
Pre-dialysis SBP (mmHg) | 150 (136–165) | 147 (137–158) | 153 (139–168) | 154 (133–163) | 156 (134–173) | 0.414 |
Pre-dialysis DBP (mmHg) | 80 (71–86) | 83 (76–88) | 80 (71–96) | 74 (66–81) | 78 (72–88) | 0.102 |
Hemoglobin (g/dL) | 10.6 (10.1–11.1) | 11.0 (10.4–11.4) | 11.0 (10.3–11.3) | 10.3 (9.8–11.0) | 10.3 (9.7–10.8) | 0.002 |
Albumin (g/dL) | 3.5 (3.2–3.7) | 3.7 (3.4–3.8) | 3.5 (3.2–3.7) | 3.4 (3.1–3.7) | 3.4 (3.1–3.5) | 0.027 |
Calcium (mg/dL) | 9.2 (8.9–9.6) | 9.0 (8.7–9.5) | 9.2 (8.8–9.7) | 9.5 (9.1–9.7) | 9.3 (8.9–9.6) | 0.133 |
Phosphorus (mg/dL) | 5.0 (4.2–5.8) | 4.8 (4.2–5.6) | 4.9 (3.8–5.7) | 5.0 (4.1–5.8) | 5.3 (4.7–6.0) | 0.404 |
Intact PTH (pg/mL) | 128 (81–198) | 151 (95–238) | 129 (97–169) | 163 (72–222) | 100 (65–159) | 0.125 |
C-related protein (mg/dL) | 0.20 (0.18–0.22) | 0.20 (0.08–0.20) | 0.20 (0.08–0.20) | 0.20 (0.20–0.23) | 0.20 (0.20–0.29) | 0.164 |
Ferritin (ng/dL) | 34 (19–71) | 41 (25–67) | 24 (18–41) | 31 (15–83) | 50 (24–85) | 0.161 |
TSAT (%) | 24.2 (18.3–29.4) | 21.4 (15.3–30.4) | 25.6 (19.5–29.4) | 26.8 (18.4–30.0) | 21.7 (17.7–29.6) | 0.551 |
Kt/V | 1.47 (1.31–1.73) | 1.45 (1.25–1.72) | 1.64 (1.27–1.74) | 1.51 (1.42–1.80) | 1.40 (1.31–1.72) | 0.345 |
ESA type (%) | ||||||
Darbepoetin alfa | 91.3 | 100 | 100 | 96.8 | 68.8 | < 0.001 |
Epoetin beta pegol | 8.7 | 0 | 0 | 3.2 | 31.3 | < 0.001 |
ESA dose (μg/week) | ||||||
Darbepoetin alfa | 15 (10–20) | 5 (5–5) | 10 (10–15) | 20 (15–20) | 40 (38–60) | < 0.001 |
Epoetin beta pegol | 75 (50–100) | NA | NA | 25 (25–25) | 75 (75–100) | < 0.001 |
ERI | 5.36 (2.73–11.31) | 1.61 (1.36–2.21) | 4.32 (3.45–4.81) | 7.37 (6.11–9.43) | 20.42 (14.76–24.45) | < 0.001 |
ARB or ACEi (%) | 62.2 | 59.4 | 64.5 | 62.5 | 62.5 | 0.980 |