Table 2 Diagnoses of adrenal insufficiency (AI) by corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) stimulation tests
From: Characteristics of adrenal insufficiency in hemodialysis patients
0 | 15 | 30 | 60 | 90 | 120 (min) | Diagnosis criteria | Diagnosis | |||
|---|---|---|---|---|---|---|---|---|---|---|
1 | CRH test | ACTH | 24.4 | 67.0 | 90.0 | 93.4 | 47.0 | 48.0 | A | Normal response |
Cortisol | 6.1 | 10.2 | 13.9 | 15.0 | 14.5 | 11.9 | ||||
ACTH test | Cortisol | 4.2 | 15.6 | 18.8 | ||||||
2 | CRH test | ACTH | 179.9 | 265.8 | 231.6 | 257.8 | 234.5 | 209.7 | C | Primary AI |
Cortisol | 4.3 | 4.7 | 5.0 | 5.2 | 5.0 | 4.9 | ||||
ACTH test | Cortisol | 5.7 | 7.7 | 8.1 | ||||||
3 | CRH test | ACTH | 73.3 | 136.2 | 140.5 | 127.5 | 95.1 | 71.8 | C | Primary AI |
Cortisol | 6.1 | 8.3 | 10.0 | 10.5 | 8.7 | 7.1 | ||||
ACTH test | Cortisol | 6.0 | 11.1 | 13.5 | ||||||
4 | CRH test | ACTH | 18.3 | 42.1 | 50.8 | 55.1 | 37.5 | 33.9 | B | Normal response |
Cortisol | 8.1 | 10.7 | 12.2 | 13.3 | 12.0 | 11.0 | ||||
ACTH test | Cortisol | 9.4 | 15.4 | 17.4 | ||||||
5 | CRH test | ACTH | 54.2 | 134.0 | 129.0 | 101.0 | 71.4 | 54.3 | B | Normal response |
Cortisol | 8.6 | 11.7 | 13.5 | 13.7 | 12.4 | 11.1 | ||||
ACTH test | Cortisol | 10.6 | 15.9 | 17.3 | ||||||
6 | CRH test | ACTH | 33.2 | 98.9 | 100.0 | 104.0 | 69.1 | 46.4 | A | Normal response |
Cortisol | 10.2 | 11.7 | 14.3 | 16.5 | 16.6 | 15.8 | ||||
ACTH test | Cortisol | 12.0 | 17.8 | 19.2 | ||||||
7 | CRH test | ACTH | 42.1 | 55.3 | 54.3 | 41.1 | 34.3 | 36.8 | A, B, and D | Secondary AI |
Cortisol | 9.1 | 10.6 | 11.5 | 10.4 | 8.8 | 7.6 | ||||
ACTH test | Cortisol | 7.6 | 15.0 | 16.7 | ||||||
8 | CRH test | ACTH | 10.8 | 33.4 | 32.7 | 26.1 | 17.7 | 14.6 | A | Normal response |
Cortisol | 9.8 | 15.0 | 19.1 | 19.9 | 16.8 | 14.2 | ||||
ACTH test | Cortisol | 7.8 | 22.8 | 27.2 | ||||||
9 | CRH test | ACTH | 26.3 | 53.4 | 53.9 | 37.4 | 29.9 | 20.7 | A | Normal response |
Cortisol | 9.9 | 13.2 | 15.1 | 15.0 | 13.1 | 11.7 | ||||
ACTH test | Cortisol | 12.0 | 19.8 | 22.9 | ||||||
10 | CRH test | ACTH | 32.1 | 43.2 | 49.9 | 41.9 | 29.1 | 25.6 | A | Normal response |
Cortisol | 13.2 | 15.1 | 16.4 | 16.9 | 13.7 | 11.7 | ||||
ACTH test | Cortisol | 10.9 | 20.6 | 22.9 | ||||||
11 | CRH test | ACTH | 26.0 | 34.5 | 42.9 | 41.9 | 48.9 | 40.6 | A | Normal response |
Cortisol | 14.9 | 14.8 | 16.8 | 17.1 | 17.7 | 16.4 | ||||
ACTH test | Cortisol | 13.2 | 22.6 | 24.5 | ||||||
12 | CRH test | ACTH | 96.5 | 120.0 | 131.0 | 111.0 | 97.5 | 72.0 | C | Primary AI |
Cortisol | 5.6 | 6.9 | 7.5 | 6.6 | 5.2 | 4.5 | ||||
ACTH test | Cortisol | 5.3 | 9.4 | 10.3 | ||||||
13 | CRH test | ACTH | 13.7 | 52.3 | 73.7 | 64.9 | 56.2 | 69.9 | A | Normal response |
Cortisol | 12.6 | 14.2 | 18.3 | 21.2 | 22.2 | 23.6 | ||||
ACTH test | Cortisol | 13.0 | 27.8 | 33.4 | ||||||
14 | CRH test | ACTH | 44.2 | 117.0 | 106.0 | 74.8 | 49.5 | 32.1 | A | Normal response |
Cortisol | 10.3 | 12.7 | 13.9 | 13.5 | 11.6 | 9.5 | ||||
ACTH test | Cortisol | 6.5 | 14.9 | 18.2 | ||||||
15 | CRH test | ACTH | 114.1 | 158.4 | 150.8 | 124.8 | 102.6 | 87.6 | C | Primary AI |
Cortisol | 9.3 | 9.8 | 9.9 | 9.8 | 9.5 | 9.2 | ||||
ACTH test | Cortisol | 15.9 | 17.1 | 17.4 | ||||||
16 | CRH test | ACTH | 37.2 | 41.6 | 35.4 | 40.1 | 42.2 | 35.1 | A and B | Primary AI |
Cortisol | 12.6 | 12.8 | 12.3 | 12.4 | 12.6 | 12.1 | ||||
ACTH test | Cortisol | 3.7 | 9.6 | 11.8 | ||||||
17 | CRH test | ACTH | 33.5 | 41.1 | 41.3 | 43.4 | 35.7 | 35.8 | A, B, and D | Secondary AI |
Cortisol | 9.1 | 8.7 | 9.4 | 9.1 | 8.3 | 7.5 | ||||
ACTH test | Cortisol | 7.5 | 15.0 | 14.7 |