Table 6 Recommended intraperitoneal anti-microbial agent dose for peritonitis treatment
Intermittent (once per day) | Continuous (for each exchange) | |
|---|---|---|
Aminoglycoside | ||
Amikacin | 2 mg/kg/day | LD 25 mg/L, MD 12 mg/L |
Gentamicin | 0.6 mg/kg/day | |
Tobramycin | 0.6 mg/kg/day | |
Cephalosporin | ||
Cefazolin | 15–20 mg/kg/day | LD 500 mg/L, MD 125 mg/L |
Cefepime | 1000 mg/day | LD 250–500 mg/L, MD 100–125 mg/L |
Cefoperazone | No data | LD 500 mg/L, MD 62.5–125 mg/L |
Cefotaxime | 500–1000 mg/day | No data |
Ceftazidime | 1000–1500 mg/day | LD 500 mg/L, MD 125 mg/L |
Ceftriaxone | 1000 mg/day | No data |
Penicillin | ||
Penicillin G | No data | LD 50,000 unit/L, MD 25,000 unit/L |
Amoxicillin | No data | MD 150 mg/L |
Ampicillin | No data | MD 125 mg/L |
Ampicillin / Sulbactam | 2 g / 1 g every 12 h | LD 750–1000 mg/L, MD 100 mg/L |
Piperacillin / Tazobactam | No data | LD 4 g / 0.5 g, MD 1 g / 0.125 g |
Other | ||
Aztreonam | 2 g/day | LD 1000 mg/L, MD 250 mg/L |
Ciprofloxacin | No data | MD 50 mg/L |
Clindamycin | No data | MD 600 mg/bag |
Daptomycin | No data | LD 100 mg/L, MD 20 mg/L |
Imipenem / Cilastin | LD 250 mg/L, MD 50 mg/L | |
Ofloxacin | No data | LD 200 mg/L, MD 25 mg/L |
Polymyxin B | No data | MD 300,000 units (30 mg)/bag |
Quinupristin / Dalfopristin | 25 mg/L per bag exchange a | No data |
Meropenem | 1 g/day | No data |
Teicoplanin | 15 mg/kg every 5 days | LD 400 mg/bag, MD 20 mg/bag |
Vancomycin | 15–30 mg/kg every 5–7 days b | LD 30 mg/kg/bag, MD 1.5 mg/kg/bag |
Anti-fungal agents | ||
Fluconazole | 200 mg IP every 24–48 h | No data |
Voriconazole | 2.5 mg/kg/day IP | No data |