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Table 6 Recommended intraperitoneal anti-microbial agent dose for peritonitis treatment

From: Peritoneal Dialysis Guidelines 2019 Part 1 (Position paper of the Japanese Society for Dialysis Therapy)

  Intermittent (once per day) Continuous (for each exchange)
Aminoglycoside
 Amikacin 2 mg/kg/day LD 25 mg/L, MD 12 mg/L
 Gentamicin 0.6 mg/kg/day  
 Tobramycin 0.6 mg/kg/day  
Cephalosporin
 Cefazolin 15–20 mg/kg/day LD 500 mg/L, MD 125 mg/L
 Cefepime 1000 mg/day LD 250–500 mg/L, MD 100–125 mg/L
 Cefoperazone No data LD 500 mg/L, MD 62.5–125 mg/L
 Cefotaxime 500–1000 mg/day No data
 Ceftazidime 1000–1500 mg/day LD 500 mg/L, MD 125 mg/L
 Ceftriaxone 1000 mg/day No data
Penicillin
 Penicillin G No data LD 50,000 unit/L, MD 25,000 unit/L
 Amoxicillin No data MD 150 mg/L
 Ampicillin No data MD 125 mg/L
 Ampicillin / Sulbactam 2 g / 1 g every 12 h LD 750–1000 mg/L, MD 100 mg/L
 Piperacillin / Tazobactam No data LD 4 g / 0.5 g, MD 1 g / 0.125 g
Other
 Aztreonam 2 g/day LD 1000 mg/L, MD 250 mg/L
 Ciprofloxacin No data MD 50 mg/L
 Clindamycin No data MD 600 mg/bag
 Daptomycin No data LD 100 mg/L, MD 20 mg/L
 Imipenem / Cilastin   LD 250 mg/L, MD 50 mg/L
 Ofloxacin No data LD 200 mg/L, MD 25 mg/L
 Polymyxin B No data MD 300,000 units (30 mg)/bag
 Quinupristin / Dalfopristin 25 mg/L per bag exchange a No data
 Meropenem 1 g/day No data
 Teicoplanin 15 mg/kg every 5 days LD 400 mg/bag, MD 20 mg/bag
 Vancomycin 15–30 mg/kg every 5–7 days b LD 30 mg/kg/bag, MD 1.5 mg/kg/bag
Anti-fungal agents
 Fluconazole 200 mg IP every 24–48 h No data
 Voriconazole 2.5 mg/kg/day IP No data
  1. LD initial (load) dose; MD maintenance dose; IP intraperitoneal; APD automatic peritoneal dialysis
  2. aImplemented in combination with a 500 mg intravenous injection twice per day
  3. bSupplemental dose may be necessary for APD patients
  4. Revised from Reference [395]