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Table 7 Recommended whole body anti-microbial agent dose for peritonitis treatment

From: Peritoneal Dialysis Guidelines 2019 Part 1 (Position paper of the Japanese Society for Dialysis Therapy)

Drug Dose
Anti-microbial agent
 Ciprofloxacin Orally, 250 mg, twice a day a
 Levofloxacin Orally, 250 mg/day
 Linezolid IV or orally 600 mg, twice a day
 Moxifloxacin Orally, 400 mg/day
 Rifampicin Sub-50 kg weight: 450 mg/day;
over 50 kg weight: 600 mg/day
 Trimethoprim / Sulfamethoxazole Orally, 160 mg / 800 mg, twice per day
Anti-fungal agent
 Amphotericin Initial dose: IV test dose, 1 mg;
6 h from start: 0.1 mg/kg/day;
Increasing from maintenance dose from day 4:
0.75–1.0 mg/kg/day
 Caspofungin Starting dose: IV 70 mg, other 50 mg/day
 Fluconazole Starting dose: orally 200 mg, other 50–100 mg/day
 Flucytosine Orally 1 g/day
 Voriconazole Orally 200 mg every 12 h
  1. IV intravenous administration
  2. a500 mg ciprofloxacin administered twice per day if the residual renal function is above 5 mL/min GFR