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Table 7 Recommended whole body anti-microbial agent dose for peritonitis treatment

From: Peritoneal Dialysis Guidelines 2019 Part 1 (Position paper of the Japanese Society for Dialysis Therapy)

Drug

Dose

Anti-microbial agent

 Ciprofloxacin

Orally, 250 mg, twice a day a

 Levofloxacin

Orally, 250 mg/day

 Linezolid

IV or orally 600 mg, twice a day

 Moxifloxacin

Orally, 400 mg/day

 Rifampicin

Sub-50 kg weight: 450 mg/day;

over 50 kg weight: 600 mg/day

 Trimethoprim / Sulfamethoxazole

Orally, 160 mg / 800 mg, twice per day

Anti-fungal agent

 Amphotericin

Initial dose: IV test dose, 1 mg;

6 h from start: 0.1 mg/kg/day;

Increasing from maintenance dose from day 4:

0.75–1.0 mg/kg/day

 Caspofungin

Starting dose: IV 70 mg, other 50 mg/day

 Fluconazole

Starting dose: orally 200 mg, other 50–100 mg/day

 Flucytosine

Orally 1 g/day

 Voriconazole

Orally 200 mg every 12 h

  1. IV intravenous administration
  2. a500 mg ciprofloxacin administered twice per day if the residual renal function is above 5 mL/min GFR