Fig. 4

Theoretical mechanism of α1-microglobulin removal by HDF. αMG physiological function, both cell differentiation inhibitory action and antioxidant action (Heme Scavenger) are presumed, but in dialysis patients, the serum concentration of αMG is > 10 times higher than normal, and the majority of them are a deteriorated (oxidized) αMG. It is presumed that turnover is also suppressed. It has been pointed out that removing the deteriorated αMG by HDF may produce new αMG from the liver and recovery the original antioxidant effect. HDF, hemodiafiltration