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Table3 Summary of 15 patients with Sphingomonas paucimobilis Peritonitis

From: A case of Sphingomonas paucimobilis causing peritoneal dialysis-associated peritonitis and review of the literature

Case

Year

Age

Gender

DM

Symptoms (first visit)

Susceptible antibiotics

Treatment

Clinical course

Outcome

References

1

1984

74

Female

No

Abdominal pain

Vomiting

Cloudy dialysate

ABPC CBPC

GM TOB

EM TC ST CP

ST IP (14 days)

Rapidly improved

Cured

[7]

2

1984

33

Female

No

Abdominal pain

Cloudy dialysate

ABPC CBPC

GM TOB

EM TC ST CP

1. CEZ IP + TOB IP

2. ABPC IP

3. AMPC orally (5 days)

4. After catheter removal, TOB IV

1 Week after treatment No3, relapsed

Catheter removed

[7]

3

1985

61

Male

No

Cloudy dialysate

CXM CAZ

Ticarcillin AMK CP

VCM IP + GM IP (duration NR)

NR

Cured

[8]

4

1985

50

Male

NR

Cloudy dialysate

NR

1. CET IP (4 days)

2. CET IP (5 days)

3. CEX orally (14 days)

4. TOB IP (14 days)

3 Weeks after treatment No1, first relapsed, after 1 week of treatment no. 3, second relapsed

Cured

[9]

5

1987

65

Male

No

NR

MZ CTX

1. VCM (10 days) + TOB (12 days) + ABPC (3 days)

2. MZ (13 days) + CX (13 days)

3. CP (13 days)

NR

Catheter removed

[10]

6

1988

38

Female

No

Cloudy dialysate

Abdominal discomfort

Nausea

CET TOB

CET IP + TOB IP (duration NR)

4 days after improvement, relapsed

Catheter removed

[11]

7

1990

64

Female

No

Cloudy dialysate

Aminoglycosides

ST

1. CPFX orally (5 days)

2. NTL IP(duration NR)

Rapidly improved

Cured

[12]

8

2007

51

Male

Yes

Abdominal pain

Fever

Cloudy dialysate

CAZ CTX CFPM IPM

SBT/CPZ TAZ/PIPC AMK CPFX

1. CEZ + AMK (14 days)

2. CEZ + CAZ (4 days)

12 days after improvement of the first peritonitis due to C. indologenes with treatment of No. 1, developed

Catheter removed

[13]

9

2008

50

Male

NR

Abdominal pain

Cloudy dialysate

ABPC PIPC IPM SBT/ABPC SBT/CPZ TAZ/PIPC GM LVFX ST

1. VCM IP, single dose

2. IPM IV + GM IP(18 days)

3. After catheter removal, IPM IV(7 days)

Continued growth of S. paucimobilis

despite dialysate without WBCs

Catheter removed

[14]

10

2011

3.5

Male

No

Abdominal pain

Fever

Cloudy dialysate

MEPM AMK TC PL

1. AMK IP (4 days)

2. MEPM IV

Rapidly improved

Cured

[15]

11

2013

63

Male

Yes

Abdominal pain

Cloudy dialysate

CAZ CTX IPM MEPM GM

MINO CPFX

1.CEZ IP + CAZ IP(14 days)

2.IPM IP

The next day after treatment of No.1, relapsed

Resistant to CAZ

Catheter removed

[16]

12

2015

50

Female

NR

Abdominal pain

Vomiting

Fever

Cloudy dialysate

CFPM MEPM

AMK CAM CPFX

1. VCM IP + CPFX IV(1 day)

2. TOB IP + CPFX IV(3 days)

3. TOB IP + MEPM IV(21 days)

Improvement after treatment of No.3

Cured

[17]

13

2016

35

Female

No

Abdominal pain

Cloudy dialysate

CTRX CFPM IPM

CPFX LVFX

1. VCM IP + CAZ IP(3 days)

2. CPFX orally + CTRX IP (21 days)

3. After catheter removal, CPFX orally + CTRX IP (14 days)

3 days after treatment of No.2, relapsed

Catheter removed

[18]

14

2018

63

Female

No

Abdominal pain

Vomiting・fever

Cloudy dialysate

CAZ AMK

GM CPFX

1. CAZ IP + VCM IP (3 days)

2. CAZ IP + AMK IP(21 days)

Rapidly improved

Cured

[19]

This case

80

Female

No

Cloudy dialysate

Table.2

1. CAZ IP (7 days) + CEZ IP(4 days)

2. MEPM IV (14 days)

3. MEPM IV(21 days) TOB IP (2 days)

3 weeks after treatment No2, relapsed

Catheter removed

  
  1. DM, diabetes mellitus; ABPC, ampicillin; AMK, amikacin; AMPC, amoxicillin; CAM, clarithromycin; CAZ, ceftazidime; CBPC, carbenicillin; CFPM, cefepime; CPFX, ciprofloxacin; CXM, cefuroxime; CP, chloramphenicol; CEX, cephalexin; CET, cefalotin; CTRX, ceftriaxone; CTX, cefotaxime; CX, cefoxitin; EM, erythromycin; GM, gentamicin; IPM, imipenem; LVFX, levofloxacin, MEPM, meropenem; MINO, minocycline; MZ, mezlocillin; NTL, netilmicin; PL, polymyxin B; SBT/ABPC, sulbactam/ampicillin; SBT/CPZ, sulbactam/cefoperazone; ST, sulfamethoxazole–trimethoprim; TAZ/PIPC, tazobactam/piperacillin; TC, tetracycline; TOM, tobramycin; VCM, vancomycin; IP, intraperitoneally; IV, intravenously; NR, not reported