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Table3 Summary of 15 patients with Sphingomonas paucimobilis Peritonitis

From: A case of Sphingomonas paucimobilis causing peritoneal dialysis-associated peritonitis and review of the literature

Case Year Age Gender DM Symptoms (first visit) Susceptible antibiotics Treatment Clinical course Outcome References
1 1984 74 Female No Abdominal pain
Vomiting
Cloudy dialysate
ABPC CBPC
GM TOB
EM TC ST CP
ST IP (14 days) Rapidly improved Cured [7]
2 1984 33 Female No Abdominal pain
Cloudy dialysate
ABPC CBPC
GM TOB
EM TC ST CP
1. CEZ IP + TOB IP
2. ABPC IP
3. AMPC orally (5 days)
4. After catheter removal, TOB IV
1 Week after treatment No3, relapsed Catheter removed [7]
3 1985 61 Male No Cloudy dialysate CXM CAZ
Ticarcillin AMK CP
VCM IP + GM IP (duration NR) NR Cured [8]
4 1985 50 Male NR Cloudy dialysate NR 1. CET IP (4 days)
2. CET IP (5 days)
3. CEX orally (14 days)
4. TOB IP (14 days)
3 Weeks after treatment No1, first relapsed, after 1 week of treatment no. 3, second relapsed Cured [9]
5 1987 65 Male No NR MZ CTX 1. VCM (10 days) + TOB (12 days) + ABPC (3 days)
2. MZ (13 days) + CX (13 days)
3. CP (13 days)
NR Catheter removed [10]
6 1988 38 Female No Cloudy dialysate
Abdominal discomfort
Nausea
CET TOB CET IP + TOB IP (duration NR) 4 days after improvement, relapsed Catheter removed [11]
7 1990 64 Female No Cloudy dialysate Aminoglycosides
ST
1. CPFX orally (5 days)
2. NTL IP(duration NR)
Rapidly improved Cured [12]
8 2007 51 Male Yes Abdominal pain
Fever
Cloudy dialysate
CAZ CTX CFPM IPM
SBT/CPZ TAZ/PIPC AMK CPFX
1. CEZ + AMK (14 days)
2. CEZ + CAZ (4 days)
12 days after improvement of the first peritonitis due to C. indologenes with treatment of No. 1, developed Catheter removed [13]
9 2008 50 Male NR Abdominal pain
Cloudy dialysate
ABPC PIPC IPM SBT/ABPC SBT/CPZ TAZ/PIPC GM LVFX ST 1. VCM IP, single dose
2. IPM IV + GM IP(18 days)
3. After catheter removal, IPM IV(7 days)
Continued growth of S. paucimobilis
despite dialysate without WBCs
Catheter removed [14]
10 2011 3.5 Male No Abdominal pain
Fever
Cloudy dialysate
MEPM AMK TC PL 1. AMK IP (4 days)
2. MEPM IV
Rapidly improved Cured [15]
11 2013 63 Male Yes Abdominal pain
Cloudy dialysate
CAZ CTX IPM MEPM GM
MINO CPFX
1.CEZ IP + CAZ IP(14 days)
2.IPM IP
The next day after treatment of No.1, relapsed
Resistant to CAZ
Catheter removed [16]
12 2015 50 Female NR Abdominal pain
Vomiting
Fever
Cloudy dialysate
CFPM MEPM
AMK CAM CPFX
1. VCM IP + CPFX IV(1 day)
2. TOB IP + CPFX IV(3 days)
3. TOB IP + MEPM IV(21 days)
Improvement after treatment of No.3 Cured [17]
13 2016 35 Female No Abdominal pain
Cloudy dialysate
CTRX CFPM IPM
CPFX LVFX
1. VCM IP + CAZ IP(3 days)
2. CPFX orally + CTRX IP (21 days)
3. After catheter removal, CPFX orally + CTRX IP (14 days)
3 days after treatment of No.2, relapsed Catheter removed [18]
14 2018 63 Female No Abdominal pain
Vomiting・fever
Cloudy dialysate
CAZ AMK
GM CPFX
1. CAZ IP + VCM IP (3 days)
2. CAZ IP + AMK IP(21 days)
Rapidly improved Cured [19]
This case 80 Female No Cloudy dialysate Table.2 1. CAZ IP (7 days) + CEZ IP(4 days)
2. MEPM IV (14 days)
3. MEPM IV(21 days) TOB IP (2 days)
3 weeks after treatment No2, relapsed Catheter removed   
  1. DM, diabetes mellitus; ABPC, ampicillin; AMK, amikacin; AMPC, amoxicillin; CAM, clarithromycin; CAZ, ceftazidime; CBPC, carbenicillin; CFPM, cefepime; CPFX, ciprofloxacin; CXM, cefuroxime; CP, chloramphenicol; CEX, cephalexin; CET, cefalotin; CTRX, ceftriaxone; CTX, cefotaxime; CX, cefoxitin; EM, erythromycin; GM, gentamicin; IPM, imipenem; LVFX, levofloxacin, MEPM, meropenem; MINO, minocycline; MZ, mezlocillin; NTL, netilmicin; PL, polymyxin B; SBT/ABPC, sulbactam/ampicillin; SBT/CPZ, sulbactam/cefoperazone; ST, sulfamethoxazole–trimethoprim; TAZ/PIPC, tazobactam/piperacillin; TC, tetracycline; TOM, tobramycin; VCM, vancomycin; IP, intraperitoneally; IV, intravenously; NR, not reported