Dosage regimens
|
Probability of target attainment over 48 h, MIC of 2 mg/L
|
---|
Effluent rates 25 mL/kg/h
|
Effluent rates 35 mL/kg/h
|
---|
40% fT > MIC
|
40% fT > 4MIC
|
100% fT > MIC
|
40% fT > MIC
|
40% fT > 4MIC
|
100% fT > MIC
|
---|
500 mg q 8 h*
|
0.9994
|
0.1708
|
0.0290
|
0.9998
|
0.1076
|
0.0172
|
750 mg q 12 h*
|
0.9850
|
0.1044
|
0.0142
|
0.9752
|
0.0598
|
0.0062
|
500 mg q 6 h*
|
1
|
0.5594
|
0.1288
|
1
|
0.4654
|
0.1074
|
1000 mg LD 500 mg q 8 h*
|
1
|
0.3090
|
0.2288
|
0.9996
|
0.2280
|
0.1706
|
1000 mg LD 500 mg q 6 h
|
1
|
0.6942
|
0.5554
|
1
|
0.6088
|
0.4992
|
750 mg q 6 h
|
1
|
0.9396
|
0.4388
|
1
|
0.9208
|
0.4122
|
1000 mg q 8 h
|
1
|
0.9280
|
0.4702
|
1
|
0.8878
|
0.4174
|
2000 mg LD 1000 mg q 8 h
|
1
|
0.9700
|
0.7122
|
1
|
0.9560
|
0.6818
|
2000 mg q 12 h
|
0.9996
|
0.9426
|
0.4750
|
0.9984
|
0.9082
|
0.3946
|
2500 mg q 8 h
|
1
|
1
|
0.9108
|
1
|
0.9996
|
0.8938
|
2000 mg q 6 h
|
1
|
1
|
0.9558
|
1
|
1
|
0.9536
|
3000 mg q 8 h
|
1
|
1
|
0.9430
|
1
|
1
|
0.9204
|
16,000 mg q 12 h
|
1
|
0.9998
|
0.9002
|
1
|
0.9996
|
0.8772
|
22,000 mg q 12 h
|
1
|
1
|
0.9334
|
1
|
1
|
0.9010
|
- PTA probability of target attainment, CVVH continuous venovenous hemofiltration, LD loading dose
- *Literature based regimens