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Table 2 PTA of all recommended imipenem dosing regimens for Pseudomonas aeruginosa infections in pre-dilution CVVH modality with 25 and 35 mL/kg/h effluent rates

From: Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations

Dosage regimens Probability of target attainment over 48 h, MIC of 2 mg/L
Effluent rates 25 mL/kg/h Effluent rates 35 mL/kg/h
40% fT > MIC 40% fT > 4MIC 100% fT > MIC 40% fT > MIC 40% fT > 4MIC 100% fT > MIC
500 mg q 8 h* 0.9994 0.1708 0.0290 0.9998 0.1076 0.0172
750 mg q 12 h* 0.9850 0.1044 0.0142 0.9752 0.0598 0.0062
500 mg q 6 h* 1 0.5594 0.1288 1 0.4654 0.1074
1000 mg LD 500 mg q 8 h* 1 0.3090 0.2288 0.9996 0.2280 0.1706
1000 mg LD 500 mg q 6 h 1 0.6942 0.5554 1 0.6088 0.4992
750 mg q 6 h 1 0.9396 0.4388 1 0.9208 0.4122
1000 mg q 8 h 1 0.9280 0.4702 1 0.8878 0.4174
2000 mg LD 1000 mg q 8 h 1 0.9700 0.7122 1 0.9560 0.6818
2000 mg q 12 h 0.9996 0.9426 0.4750 0.9984 0.9082 0.3946
2500 mg q 8 h 1 1 0.9108 1 0.9996 0.8938
2000 mg q 6 h 1 1 0.9558 1 1 0.9536
3000 mg q 8 h 1 1 0.9430 1 1 0.9204
16,000 mg q 12 h 1 0.9998 0.9002 1 0.9996 0.8772
22,000 mg q 12 h 1 1 0.9334 1 1 0.9010
  1. PTA probability of target attainment, CVVH continuous venovenous hemofiltration, LD loading dose
  2. *Literature based regimens