Table 2 PTA of all recommended imipenem dosing regimens for Pseudomonas aeruginosa infections in pre-dilution CVVH modality with 25 and 35 mL/kg/h effluent rates
Dosage regimens | Probability of target attainment over 48 h, MIC of 2 mg/L | |||||
|---|---|---|---|---|---|---|
Effluent rates 25 mL/kg/h | Effluent rates 35 mL/kg/h | |||||
40% fT > MIC | 40% fT > 4MIC | 100% fT > MIC | 40% fT > MIC | 40% fT > 4MIC | 100% fT > MIC | |
500 mg q 8 h* | 0.9994 | 0.1708 | 0.0290 | 0.9998 | 0.1076 | 0.0172 |
750 mg q 12 h* | 0.9850 | 0.1044 | 0.0142 | 0.9752 | 0.0598 | 0.0062 |
500 mg q 6 h* | 1 | 0.5594 | 0.1288 | 1 | 0.4654 | 0.1074 |
1000 mg LD 500 mg q 8 h* | 1 | 0.3090 | 0.2288 | 0.9996 | 0.2280 | 0.1706 |
1000 mg LD 500 mg q 6 h | 1 | 0.6942 | 0.5554 | 1 | 0.6088 | 0.4992 |
750 mg q 6 h | 1 | 0.9396 | 0.4388 | 1 | 0.9208 | 0.4122 |
1000 mg q 8 h | 1 | 0.9280 | 0.4702 | 1 | 0.8878 | 0.4174 |
2000 mg LD 1000 mg q 8 h | 1 | 0.9700 | 0.7122 | 1 | 0.9560 | 0.6818 |
2000 mg q 12 h | 0.9996 | 0.9426 | 0.4750 | 0.9984 | 0.9082 | 0.3946 |
2500 mg q 8 h | 1 | 1 | 0.9108 | 1 | 0.9996 | 0.8938 |
2000 mg q 6 h | 1 | 1 | 0.9558 | 1 | 1 | 0.9536 |
3000 mg q 8 h | 1 | 1 | 0.9430 | 1 | 1 | 0.9204 |
16,000 mg q 12 h | 1 | 0.9998 | 0.9002 | 1 | 0.9996 | 0.8772 |
22,000 mg q 12 h | 1 | 1 | 0.9334 | 1 | 1 | 0.9010 |