Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations

Table 4 Virtual patient characteristics and key pharmacokinetic parameters from simulation

Parameters	Simulation-based values (mean ± SD (range limits))
Weight (kg)	86.6 ± 29.2 (40− ∞), N = 100
V_d (L/kg)	0.34 ± 0.11 (0.15–0.63), N = 33
CL_NR (mL/min)	103.82 ± 28.95 (52.51–168.0), N = 31
Residual renal clearance (mL/min)	0
SC	1.05 ± 0.17 (0.8–1.34), N = 32
SA	0.77 ± 0.33 (0.37–1.52), N = 54
Qb (mL/min)	200
Hct (%)	30
Qf or Qd (mL/kg/h)	25 and 35
Free fraction	0.8 ± 0.16
Pharmacodynamic target	40% fT > MIC 40% fT > 4MIC 100% fT > MIC

SD standard deviation, kg kilogram, N number of patients, L liter, mL milliliter, min minute, SC seiving coefficient, SD saturation coefficient, Qb blood flow rate, Hct hematocrit, Qf ultrafiltration rate, Qd dialysate flow rate, fT/MIC free drug level above 4 times of the minimum inhibitory concentration

ISSN: 2059-1381