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Table 4 Virtual patient characteristics and key pharmacokinetic parameters from simulation

From: Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations

Parameters Simulation-based values (mean ± SD (range limits))
Weight (kg) 86.6 ± 29.2 (40− ∞), N = 100
Vd (L/kg) 0.34 ± 0.11 (0.15–0.63), N = 33
CLNR (mL/min) 103.82 ± 28.95 (52.51–168.0), N = 31
Residual renal clearance (mL/min) 0
SC 1.05 ± 0.17 (0.8–1.34), N = 32
SA 0.77 ± 0.33 (0.37–1.52), N = 54
Qb (mL/min) 200
Hct (%) 30
Qf or Qd (mL/kg/h) 25 and 35
Free fraction 0.8 ± 0.16
Pharmacodynamic target 40% fT > MIC
40% fT > 4MIC
100% fT > MIC
  1. SD standard deviation, kg kilogram, N number of patients, L liter, mL milliliter, min minute, SC seiving coefficient, SD saturation coefficient, Qb blood flow rate, Hct hematocrit, Qf ultrafiltration rate, Qd dialysate flow rate, fT/MIC free drug level above 4 times of the minimum inhibitory concentration