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Table 5 Recommendations of imipenem dosing regimens for treating Pseudomonas aeruginosa infections with various PD target in critically ill patients undergoing CRRT

From: Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations

PD target Effluent rates (mL/kg/h) CVVH (pre-hemofilter dilution) CVVHD
40% fT > MIC 25 mL/kg/h 500 mg q 8 h or
750 mg q 12 h
500 mg q 8 h
35 mL/kg/h 750 mg q 12 h
40% fT > 4MIC 25 mL/kg/h 750 mg q 6 h 750 mg q 6 h
35 mL/kg/h
100% fT > MIC 25 mL/kg/h 2500 mg q 8 h 1500 mg q 6 h
35 mL/kg/h 2000 mg q 6 h 2000 mg LD then
1500 mg q 6 h
  1. CVVH continuous venovenous hemofiltration, CVVHD continuous venovenous hemodialysis, LD loading dose