From: Effects of Japanese-style online hemodiafiltration on survival and cardiovascular events
Item | HD | OHDF | p-value1) | pre-OHDF | post-OHDF | p-value2) |
---|---|---|---|---|---|---|
Total (n) | 356 | 441 | 345 | 96 | ||
Sex, male/female (%) | 64.0/36.0 | 66.4/33.6 | 0.528 | 66.1/33.9 | 67.7/32.3 | 0.746 |
Underlying disease | < 0.001 | < 0.001 | ||||
Chronic nephropathy (%) | 26.7 | 39.5 | 36.5 | 50.0 | ||
Diabetic nephropathy (%) | 34.4 | 30.8 | 32.5 | 25.0 | ||
Nephrosclerosis (%) | 17.4 | 7.9 | 8.7 | 5.2 | ||
Other (%) | 21.6 | 21.8 | 22.3 | 19.8 | ||
Diabetes mellitus, yes/no (%) | 38.5/61.5 | 33.1/66.9 | 0.133 | 34.5/65.5 | 28.1/71.9 | 0.148 |
History of myocardial infarction, yes/no (%) | 1.7/98.3 | 2.0/98.0 | 0.916 | 2.0/98.0 | 2.1/97.9 | 0.943 |
History of intracerebral bleeding, yes/no (%) | 0.6/99.4 | 0.9/99.1 | 0.882 | 0.9/99.1 | 1.0/99.0 | 0.842 |
History of cerebral infarction, yes/no (%) | 4.8/95.2 | 3.4/96.6 | 0.423 | 3.2/96.8 | 4.2/95.8 | 0.562 |
History of quadruple amputation, yes/no (%) | 0.8/99.2 | 1.1/98.9 | 0.958 | 1.2/98.8 | 1.0/99.0 | 0.915 |
Use of antihypertensive agents, yes/no (%) | 40.2/59.8 | 37.0/63.0 | 0.394 | 37.4/62.6 | 35.4/64.6 | 0.613 |
Age (years) | 72.6 ± 10.9 | 64.6 ± 11.7 | < 0.001 | 65.4 ± 11.7 | 61.8 ± 11.3 | < 0.001 |
Dialysis vintage (months) | 98.2 ± 93.1 | 145.2 ± 118.4 | < 0.001 | 144.8 ± 118.7 | 146 ± 118.0 | < 0.001 |
Blood flow rate (mL/min) | 268.0 ± 19.8 | 279.5 ± 20.3 | < 0.001 | 279.0 ± 19.7 | 281.3 ± 22.4 | < 0.001 |
Duration of dialysis session (h) | 4 ± 0 | 4 ± 0 | > 0.999 | 4 ± 0 | 4 ± 0 | > 0.999 |
Systolic BP, predialysis (mmHg) | 142 ± 23 | 144 ± 25 | 0.334 | 143 ± 26 | 146 ± 21 | 0.461 |
Diastolic BP, predialysis (mmHg) | 74 ± 13 | 77 ± 14 | < 0.001 | 77 ± 15 | 79 ± 13 | < 0.001 |
Body mass index (calculated as kg/m2) | 21.5 ± 3.8 | 22.7 ± 3.8 | < 0.001 | 22.7 ± 3.8 | 22.8 ± 4.1 | < 0.001 |
Albumin, predialysis (g/dL) | 3.3 ± 0.4 | 3.4 ± 0.3 | 0.001 | 3.4 ± 0.3 | 3.3 ± 0.3 | < 0.001 |
High-sensitivity CRP, predialysis (g/dL) | 0.566 ± 1.377 | 0.404 ± 1.168 | 0.072 | 0.403 ± 1.122 | 0.406 ± 1.326 | 0.199 |
Corrected calcium, predialysis (m/dL) | 9.2 ± 0.7 | 9.2 ± 0.7 | 0.767 | 9.2 ± 0.7 | 9.2 ± 0.6 | 0.793 |
Phosphorus, predialysis (m/dL) | 4.9 ± 1.5 | 5.5 ± 1.4 | 0.000 | 5.5 ± 1.4 | 5.5 ± 1.6 | < 0.001 |
Hemoglobin, predialysis (m/dL) | 11.0 ± 1.2 | 11.2 ± 1.2 | 0.023 | 11.2 ± 1.3 | 11.2 ± 1.1 | 0.069 |
Ferritin (ng/mL) | 75.4 ± 89.8 | 72.7 ± 134.5 | 0.753 | 75.7 ± 147.4 | 61.5 ± 70.1 | 0.546 |
Kt/V | 1.7 ± 0.3 | 1.6 ± 0.3 | < 0.001 | 1.6 ± 0.3 | 1.7 ± 0.3 | < 0.001 |
Creatinine, predialysis (mg/dL) | 9.39 ± 3.04 | 11.34 ± 2.93 | < 0.001 | 11.21 ± 2.86 | 11.82 ± 3.12 | < 0.001 |
Blood urea nitrogen, predialysis (mg/dL) | 54.6 ± 16.0 | 58.8 ± 14.1 | < 0.001 | 59.0 ± 14.3 | 58.0 ± 13.1 | < 0.001 |
Substitution volume (L) | ||||||
Mean | 71.3 ± 12.0 | 10.4 ± 2.2 | ||||
Median (quartile range) | 72 (60–84) | 10 (8–12) |