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Table 1 Background factors in the HD, OHDF, pre-OHDF, and post-OHDF groups

From: Effects of Japanese-style online hemodiafiltration on survival and cardiovascular events

Item

HD

OHDF

p-value1)

pre-OHDF

post-OHDF

p-value2)

Total (n)

356

441

 

345

96

 

Sex, male/female (%)

64.0/36.0

66.4/33.6

0.528

66.1/33.9

67.7/32.3

0.746

Underlying disease

  

 < 0.001

  

 < 0.001

Chronic nephropathy (%)

26.7

39.5

 

36.5

50.0

 

Diabetic nephropathy (%)

34.4

30.8

 

32.5

25.0

 

Nephrosclerosis (%)

17.4

7.9

 

8.7

5.2

 

Other (%)

21.6

21.8

 

22.3

19.8

 

Diabetes mellitus, yes/no (%)

38.5/61.5

33.1/66.9

0.133

34.5/65.5

28.1/71.9

0.148

History of myocardial infarction, yes/no (%)

1.7/98.3

2.0/98.0

0.916

2.0/98.0

2.1/97.9

0.943

History of intracerebral bleeding, yes/no (%)

0.6/99.4

0.9/99.1

0.882

0.9/99.1

1.0/99.0

0.842

History of cerebral infarction, yes/no (%)

4.8/95.2

3.4/96.6

0.423

3.2/96.8

4.2/95.8

0.562

History of quadruple amputation, yes/no (%)

0.8/99.2

1.1/98.9

0.958

1.2/98.8

1.0/99.0

0.915

Use of antihypertensive agents, yes/no (%)

40.2/59.8

37.0/63.0

0.394

37.4/62.6

35.4/64.6

0.613

Age (years)

72.6 ± 10.9

64.6 ± 11.7

 < 0.001

65.4 ± 11.7

61.8 ± 11.3

 < 0.001

Dialysis vintage (months)

98.2 ± 93.1

145.2 ± 118.4

 < 0.001

144.8 ± 118.7

146 ± 118.0

 < 0.001

Blood flow rate (mL/min)

268.0 ± 19.8

279.5 ± 20.3

 < 0.001

279.0 ± 19.7

281.3 ± 22.4

 < 0.001

Duration of dialysis session (h)

4 ± 0

4 ± 0

 > 0.999

4 ± 0

4 ± 0

 > 0.999

Systolic BP, predialysis (mmHg)

142 ± 23

144 ± 25

0.334

143 ± 26

146 ± 21

0.461

Diastolic BP, predialysis (mmHg)

74 ± 13

77 ± 14

 < 0.001

77 ± 15

79 ± 13

 < 0.001

Body mass index (calculated as kg/m2)

21.5 ± 3.8

22.7 ± 3.8

 < 0.001

22.7 ± 3.8

22.8 ± 4.1

 < 0.001

Albumin, predialysis (g/dL)

3.3 ± 0.4

3.4 ± 0.3

0.001

3.4 ± 0.3

3.3 ± 0.3

 < 0.001

High-sensitivity CRP, predialysis (g/dL)

0.566 ± 1.377

0.404 ± 1.168

0.072

0.403 ± 1.122

0.406 ± 1.326

0.199

Corrected calcium, predialysis (m/dL)

9.2 ± 0.7

9.2 ± 0.7

0.767

9.2 ± 0.7

9.2 ± 0.6

0.793

Phosphorus, predialysis (m/dL)

4.9 ± 1.5

5.5 ± 1.4

0.000

5.5 ± 1.4

5.5 ± 1.6

 < 0.001

Hemoglobin, predialysis (m/dL)

11.0 ± 1.2

11.2 ± 1.2

0.023

11.2 ± 1.3

11.2 ± 1.1

0.069

Ferritin (ng/mL)

75.4 ± 89.8

72.7 ± 134.5

0.753

75.7 ± 147.4

61.5 ± 70.1

0.546

Kt/V

1.7 ± 0.3

1.6 ± 0.3

 < 0.001

1.6 ± 0.3

1.7 ± 0.3

 < 0.001

Creatinine, predialysis (mg/dL)

9.39 ± 3.04

11.34 ± 2.93

 < 0.001

11.21 ± 2.86

11.82 ± 3.12

 < 0.001

Blood urea nitrogen, predialysis (mg/dL)

54.6 ± 16.0

58.8 ± 14.1

 < 0.001

59.0 ± 14.3

58.0 ± 13.1

 < 0.001

Substitution volume (L)

      

Mean

   

71.3 ± 12.0

10.4 ± 2.2

 

Median (quartile range)

   

72 (60–84)

10 (8–12)

 
  1. HD, hemodialysis; OHDF, online hemodiafiltration; pre-OHDF predilution online hemodiafiltration; post-OHDF, postdilution online hemodiafiltration; BP, blood pressure; CRP, C-reactive protein
  2. 1) Test between HD and OHDF (Chi squared test or t-test); 2) Test among OHDF, pre-OHDF and post-OHDF (Chi squared test or One-way ANOVA)