Fig. 2

Serial changes in numerical rating scale (NRS) scores for fatigue on the hemodialysis (HD) day (a) and the HD-free day (b). *p = 0.038 vs. baseline, + :p = 0.035 versus baseline, #: p = 0.002 versus baseline. NRS (mean ± SD). Baseline: within 2 weeks before the start of study. Group A (n = 16): patients who reported fatigue on both HD and HD-free days at baseline; Group B (n = 30): patients who reported fatigue on HD days, but not on HD-free days; Group C (n = 59): patients who did not report fatigue on both HD and HD-free days