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Table 2 Comparison of patients who presented absence of or a decrease in the level of fatigue on HD day (Improved group) with those who did not present decrease in the level of fatigue (Non-improved group) at baseline as compared to 8th week

From: Impact of hemodialysis solutions containing different levels of molecular hydrogen (H2) on the patient-reported outcome of fatigue

 

Improved group (I)

(n = 64)

 

Non-improved group (M)

(n = 41)

 

Group I versus N

Ow

8w

p value

Ow

8w

p value

NRS on HD day

3.51 ±  2.66

2.09 ± 1.98

0.00

3.75 ± 2.35

5.65 ± 2.12

0.00

Ow: 0.62, 8w: 0.00

NRS on HD-free day

1.65 ±  1.87

1.23 ± 1.46

0.03

2.12 ± 1.74

3.41 ± 1.80

0.00

Ow: 0.19, 8w: 0.00

Age (years)

65.3 ± 11.9

  

68.4 ± 10.7

  

0.18

HD vintage (months)

103 ± 99

  

136 ± 121

  

0.12

Male (%)

39 (60.9%)

  

22 (53.7%)

  

0.59

DM

38 (59.4%)

  

21 (51.2%)

  

0.53

CVD

21(32.8%)

  

13 (31.7%)

  

0.99

AHA

33 (51.6%)

30 (46.9%)

0.72

28 (68.3%|

28 (68.3%)

1.00

Ow: 0.13, 8w: 0.05

UF(L)

2.8 ± 0.7

2.8 ± 0.6

0.65

2.6 ± 0.7

2.6 ± 0.6

0.82

Ow.0.12

Dry weight (kg)

61.7 ± 15.0

61.8 ± 14.9

0.32

55.0 ± 14.2

56.5 ± 12.2

0.37

Ow: 0.02

CTR (%)

48.5 ±  5.1

47.9 ± 4.8

0.04

46.4 ± 3.8

46.5 ± 5.1

0.80

Ow: 0.03

Pre-SBP (mmHg)

160 ± 27

155 ± 26

0.06

154 ± 20

146 ± 18

0.01

Ow: 0.25, 8w: 0.05

DBP

82  ± 13

79 ± 12

0.01

78 ± 12

75 ± 10

0.05

Ow: 0.12, 8w: 0.08

Post-SBP (mmHg)

133 ± 17

127 ± 20

0.01

128 ± 20

125 ± 15

0.17

Ow: 0.21, 8w: 0.51

DBP

70 ± 11

67 ± 13

0.02

70 ± 14

67 ± 13

0.06

0w:0.81, 8 W.0.79

Hb (g/dL)

10.8 ± 0.9

10.8 ± 0.9

0.96

11.2 ± 0.9

10.7 ± 1.0

0.01

Ow: 0.05

Pre-MPO (pg/mL)

74.8 ± 58.5

74.2 ± 63.0

0.84

71.0 ± 46.7

68.5 ± 64.1

0.48

0w:0.72, 8w: 0.65

Post-MPO (pg/mL)

307.7 ± 244.7

277.8 ± 217.1

0.28

244.8 ± 151.8

262.3 ± 229.6

0.34

0w:0.14, 8w: 0.73

  1. NRS, Numerical rating scale (0 to 10); HD, hemodialysis; DM, diabetes mellitus; CVD, cardiovascular diseases; AHA, antihypertensive agents; UF, ultrafiltration volume; CTR, cardiothoracic ratio; pre, pre-HD; post, post-HD; SBP, systolic blood pressure; DBP, diastolic blood pressure; Hb, hemoglobin; MPO, myeloperoxidase.