|  | Local | Systemic | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pain | Redness | Swelling | Pruritus | Fatigue | Headache | Muscle pain | Coldness | Fever | Arthralgia | Nausea | Diarrhea | Stomachache | Anaphylaxis | ||
All | |||||||||||||||
First vaccine | Control (n = 121) | 67 | 11 | 14 | 15 | 23 | 7 | 32 | 2 | 7 | 3 | 0 | 3 | 2 | 0 |
 | HD (n = 208) | 107 | 13 | 19 | 19 | 24 | 5 | 52 | 3 | 5 | 7 | 5 | 5 | 1 | 0 |
 | p value | 0.49 | 0.34 | 0.48 | 0.35 | 0.06 | 0.11 | 0.77 | 0.88 | 0.11 | 0.65 | 0.09 | 0.97 | 0.28 | > 0.99 |
Second vaccine | Control (n = 121) | 61 | 12 | 17 | 24 | 27 | 14 | 30 | 4 | 21 | 5 | 0 | 0 | 0 | 0 |
 | HD (n = 208) | 109 | 15 | 21 | 26 | 50 | 23 | 52 | 16 | 57 | 16 | 9 | 4 | 4 | 0 |
 | p value | 0.73 | 0.39 | 0.28 | 0.07 | 0.72 | 0.89 | 0.97 | 0.11 | 0.039 | 0.20 | 0.020 | 0.12 | 0.12 | > 0.99 |
Male | |||||||||||||||
First vaccine | Control (n = 74) | 40 | 4 | 5 | 5 | 10 | 5 | 15 | 0 | 4 | 1 | 0 | 3 | 2 | 0 |
 | HD (n = 134) | 62 | 5 | 5 | 9 | 11 | 3 | 35 | 2 | 5 | 6 | 2 | 2 | 1 | 0 |
 | p value | 0.28 | 0.56 | 0.32 | 0.71 | 0.22 | 0.11 | 0.35 | 0.29 | 0.57 | 0.23 | 0.29 | 0.25 | 0.26 | > 0.99 |
Second vaccine | Control (n = 74) | 34 | 4 | 4 | 9 | 14 | 7 | 14 | 1 | 10 | 4 | 0 | 0 | 0 | 0 |
 | HD (n = 134) | 65 | 7 | 9 | 12 | 26 | 12 | 33 | 9 | 36 | 14 | 7 | 2 | 3 | 0 |
 | p value | 0.72 | 0.96 | 0.71 | 0.46 | 0.93 | 0.90 | 0.35 | 0.08 | 0.026 | 0.21 | 0.046 | 0.29 | 0.19 | > 0.99 |
Female | |||||||||||||||
First vaccine | Control (n = 46) | 27 | 7 | 9 | 10 | 13 | 2 | 17 | 2 | 3 | 2 | 0 | 0 | 0 | 0 |
 | HD (n = 73) | 45 | 8 | 14 | 10 | 13 | 2 | 17 | 1 | 0 | 1 | 3 | 3 | 0 | 0 |
 | p value | 0.75 | 0.50 | 0.96 | 0.25 | 0.18 | 0.63 | 0.11 | 0.31 | 0.027 | 0.31 | 0.16 | 0.16 | > 0.99 | > 0.99 |
Second vaccine | Control (n = 46) | 27 | 8 | 13 | 15 | 13 | 7 | 16 | 3 | 11 | 1 | 0 | 0 | 0 | 0 |
 | HD (n = 73) | 44 | 8 | 12 | 14 | 24 | 11 | 19 | 7 | 21 | 2 | 2 | 2 | 1 | 0 |
 | p value | 0.86 | 0.32 | 0.12 | 0.10 | 0.60 | 0.98 | 0.31 | 0.56 | 0.56 | 0.85 | 0.26 | 0.26 | 0.43 | > 0.99 |