Fig. 1From: A case of severe generalized pustular psoriasis successfully treated with IL-17A monoclonal antibody and granulocyte removal therapyLeft thigh skin biopsy specimen. The sample was taken from the epidermis to the subcutaneous fatty tissue. Multiple pustule formations are seen in the epidermis with numerous neutrophilic clusters jumping up the stratum corneum, and infiltration is seen between the surrounding spinous cells. Other than the apparent pustules, the epidermis is also infiltrated by neutrophils, mainly in the subcutaneous cornea, often forming microabscesses. There is a mild extension of the epidermal processes on the basal side, which are relatively uniform in length. The dermis also shows inflammatory cell infiltrates, mainly lymphocytes, in shallow perivascular areas—findings of pustular psoriasisBack to article page