Effects of high albumin leakage on survival between online hemodiafiltration and super high-flux hemodialysis: the HISTORY study

Okada, Kazuyoshi; Tashiro, Manabu; Michiwaki, Hiroyuki; Inoue, Tomoko; Shima, Hisato; Minakuchi, Jun; Kawashima, Shu

doi:10.1186/s41100-022-00440-5

Table 5 Comparison of variables between super high-flux hemodialysis (SHF-HD) and online hemodiafiltration (OHDF) by the same ranges of the estimated albumin leakage (EAL)

From: Effects of high albumin leakage on survival between online hemodiafiltration and super high-flux hemodialysis: the HISTORY study

Item	Before matching			After matching
Item	EAL < 2.5 g/session in SHF-HD	EAL < 2.5 g/session in OHDF	P value	EAL < 2.5 g/session in SHF-HD	EAL < 2.5 g/session in OHDF	P value
(a) EAL < 2.5 g in SHF-HD versus OHDF
Patients, n	217	83		75	75
Age, years	74.8 ± 10.7	72.4 ± 9.5	0.043	73.1 ± 10.2	72.8 ± 9.8	0.959
Dialysis vintage, months	89.1 ± 90.2	150.5 ± 138.3	< 0.001	173.3 ± 97.5	121.9 ± 109.9	< 0.001
Diabetes mellitus, % with/without	40.1/59.9	34.9/65.1	0.430	32.0/68.0	38.7/61.3	0.495
Body mass index, kg/m²	21.0 ± 3.6	21.1 ± 3.0	0.638	20.7 ± 3.4	21.1 ± 3.0	0.551
Normalized protein catabolism rate, g/kg/day	0.8 ± 0.2	0.8 ± 0.2	0.069	0.8 ± 0.2	0.8 ± 0.2	0.762
Corrected calcium, mg/dL	9.3 ± 0.7	9.3 ± 0.6	0.798	9.4 ± 0.7	9.3 ± 0.6	0.112
Phosphorus, mg/dL	4.8 ± 1.4	5.2 ± 1.2	0.028	5.0 ± 1.4	5.2 ± 1.2	0.517
Hemoglobin, g/dL	10.9 ± 1.1	10.8 ± 1.1	0.728	10.8 ± 1.1	10.8 ± 1.0	0.873
High-sensitivity C-reactive protein, mg/dL	0.724 ± 1.684	0.229 ± 0.403	0.007	0.468 ± 1.282	0.236 ± 0.423	0.046
Kt/V	1.7 ± 0.4	1.6 ± 0.3	0.006	1.7 ± 0.4	1.6 ± 0.3	0.147
(b) 2.5 ≤ EAL < 5.0 g/session in SHF-HD versus OHDF
Patients, n	117	121		103	103
Age, years	70.2 ± 9.9	67.3 ± 10.5	0.049	69.5 ± 9.8	69.0 ± 9.6	0.842
Dialysis vintage, months	106.0 ± 91.3	115.2 ± 93.2	0.362	116.9 ± 91.5	116.5 ± 94.6	0.835
Diabetes mellitus, % with/without	36.8/63.2	41.3/58.7	0.508	38.8/61.2	38.8/61.2	> 0.999
Body mass index, kg/m²	22.1 ± 4.1	23.5 ± 4.6	0.006	22.2 ± 4.2	22.5 ± 3.6	0.237
Normalized protein catabolism rate, g/kg/day	0.8 ± 0.2	0.8 ± 0.2	0.799	0.8 ± 0.2	0.9 ± 0.2	0.876
Corrected calcium, mg/dL	9.2 ± 0.7	9.2 ± 0.7	0.391	9.1 ± 0.7	9.2 ± 0.7	0.340
Phosphorus, mg/dL	5.0 ± 1.3	5.4 ± 1.4	0.131	5.1 ± 1.4	5.3 ± 1.5	0.465
Hemoglobin, g/dL	11.2 ± 1.1	11.1 ± 1.4	0.155	11.2 ± 1.1	11.1 ± 1.5	0.115
High-sensitivity C-reactive protein, mg/dL	0.266 ± 0.429	0.514 ± 1.394	0.815	0.289 ± 0.451	0.342 ± 0.838	0.628
Kt/V	1.7 ± 0.3	1.6 ± 0.3	0.038	1.7 ± 0.3	1.6 ± 0.3	0.331

Item	Before matching			After matching
Item	5.0 ≤ EAL < 7.5 g/session in SHF-HD	5.0 ≤ EAL < 7.5 g/session in OHDF	P value	5.0 ≤ EAL < 7.5 g/session in SHF-HD	5.0 ≤ EAL < 7.5 g/session in OHDF	P value
(c) 5.0 ≤ EAL < 7.5 g/session in SHF-HD versus OHDF
Patients, n	21	179		20	20
Age, years	64.0 ± 12.2	61.2 ± 11.4	0.312	63.4 ± 12.2	62.1 ± 12.5	0.892
Dialysis vintage, months	136.1 ± 106.6	150.5 ± 118.5	0.692	142.0 ± 105.8	136.9 ± 120.7	0.787
Diabetes mellitus, % with/without	33.3/66.7	28.5/71.5	0.620	35.0/65.0	25.0/75.0	0.731
Body mass index, kg/m²	23.8 ± 3.4	22.8 ± 3.5	0.162	23.7 ± 3.5	22.6 ± 3.7	0.433
Normalized protein catabolism rate, g/kg/day	0.8 ± 0.2	0.9 ± 0.1	0.346	0.8 ± 0.2	0.8 ± 0.1	0.871
Corrected calcium, mg/dL	9.1 ± 0.5	9.1 ± 0.7	0.886	9.1 ± 0.6	9.2 ± 0.5	0.871
Phosphorus, mg/dL	5.5 ± 2.1	5.7 ± 1.5	0.524	5.6 ± 2.0	6.0 ± 1.6	0.440
Hemoglobin, g/dL	11.1 ± 1.3	11.4 ± 1.2	0.498	11.1 ± 1.3	11.3 ± 1.2	0.665
High-sensitivity C-reactive protein, mg/dL	0.617 ± 1,069	0.330 ± 0.955	0.020	0.411 ± 0.513	0.255 ± 0.263	0.344
Kt/V	1.6 ± 0.2	1.6 ± 0.3	0.632	1.6 ± 0.2	1.6 ± 0.3	0.925

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