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Table 2 Factors influencing Δβ2MG

From: Impact on change in serum beta 2 microglobulin by combination therapy of peritoneal dialysis and hemodialysis: a 12-month preliminary observational study

 

Univariate analysis (n = 11)

Multivariate analysis (n = 11)

Correlation coefficient

95% CI

p

β

95% CI

p

Δβ2MG (0–3 months)

Age

0.155

(− 0.49 to 0.6907)

0.650

   

Body mass index*

 − 0.073

(− 0.645 to 0.551)

0.830

   

Vintage of PD therapy

 − 0.005

(− 0.603 to 0.5967)

0.989

   

Hemoglobin*

 − 0.162

(− 0.694 to 0.485)

0.635

   

Serum albumin*

 − 0.656

(− 0.901 to − 0.093)

0.028

 − 0.990

(− 21.016 to − 1.425)

0.032

Blood urea nitrogen*

0.502

(− 0.14 to 0.8469)

0.115

   

Creatinine*

 − 0.073

(− 0.645 to 0.551)

0.831

   

C-reactive protein*

0.174

(− 0.476 to 0.7007)

0.609

   

Baseline beta 2 microglobulin

 − 0.456

(− 0.829 to 0.1981)

0.159

0.273

(− 0.322 to 0.674)

0.406

Total PD fluid volume*

 − 0.089

(− 0.654 to 0.5397)

0.794

   

Weekly Kt/V of PD

0.138

(− 0.504 to 0.6815)

0.686

   

Blood flow rate of HD session*

 − 0.399

(− 0.806 to 0.2641)

0.308

0.301

(− 0.062 to 0.173)

0.279

Kt/V of HD*

 − 0.54

(− 0.861 to 0.0886)

0.087

   

Renal Kt/V

0.604

(2.231 to 1170.269)

0.049

   

Urine volume

0.623

(0.002 to 0.056)

0.041

0.960

(− 0.003 to 0.091)

0.059

Renal CCr

0.658

(0.129 to 1.755)

0.028

 − 0.293

(− 1.920 to 1.080)

0.504

Δβ2MG (0–6 months)

Age

0.221

(− 0.475 to 0.7467)

0.514

   

Body mass index*

 − 0.489

(− 0.855 to 0.2032)

0.126

   

Vintage of PD therapy

0.1

(− 0.565 to 0.6864)

0.756

   

Hemoglobin*

0.104

(− 0.562 to 0.6885)

0.761

   

Serum albumin*

 − 0.36

(− 0.807 to 0.3487)

0.277

 − 0.155

(− 8.021 to 4.246)

0.465

Blood urea nitrogen*

 − 0.067

(− 0.668 to 0.5874)

0.845

   

Creatinine*

 − 0.332

(− 0.795 to 0.3763)

0.318

   

C-reactive protein*

 − 0.298

(− 0.781 to 0.4082)

0.377

   

Baseline beta 2 microglobulin

 − 0.764

(− 0.941 to − 0.259)

0.006

 − 0.659

(− 0.851 to 0.076)

0.084

Total PD fluid volume*

0

(− 0.63 to 0.6296)

    

Weekly Kt/V of PD

0.037

(− 0.607 to 0.6515)

0.914

   

Blood flow rate of HD session*

 − 0.609

(− 0.895 to 0.0335)

0.047

0.054

(− 0.096 to 0.110)

0.873

Kt/V of HD*

 − 0.487

(− 0.855 to 0.2057)

0.129

   

Renal Kt/V*

0.452

(− 141.589 to 722.894)

0.163

   

Urine volume*

0.587

(− 0.001 to 0.040)

0.058

0.995

(− 0.007 to 0.074)

0.084

Renal CCr*

0.437

(− 0.315 to 1.451)

0.179

 − 0.621

(− 2.403 to 0.788)

0.250

Δβ2MG (0–12 months)

Age

0.093

(− 0.57 to 0.6827)

0.785

   

Body mass index*

 − 0.324

(− 0.792 to 0.384)

0.332

   

Vintage of PD therapy

 − 0.017

(− 0.64 to 0.6193)

0.960

   

Hemoglobin*

 − 0.093

(− 0.683 to 0.57)

0.786

   

Serum albumin*

 − 0.746

(− 0.936 to − 0.219)

0.008

 − 0.551

(− 16.559 to − 0.983)

0.033

Blood urea nitrogen*

0.443

(− 0.259 to 0.8387)

0.173

   

Creatinine*

 − 0.267

(− 0.768 to 0.4359)

0.428

   

C-reactive protein*

 − 0.276

(− 0.772 to 0.428)

0.411

   

Baseline beta 2 microglobulin

 − 0.629

(− 0.902 to 0.001)

0.038

 − 0.181

(− 0.685 to 0.438)

0.609

Total PD fluid volume*

0.062

(− 0.591 to 0.6656)

0.856

   

Weekly Kt/V of PD

0.099

(− 0.566 to 0.6859)

0.773

   

Blood flow rate of HD session*

 − 0.336

(− 0.797 to 0.3724)

0.313

 − 0.076

(− 0.136 to 0.109)

0.799

Kt/V of HD*

 − 0.09

(− 0.681 to 0.572)

0.792

   

Renal Kt/V*

0.616

(17.093 to 970.907)

0.044

   

Urine volume*

0.616

(0.001 to 0.049)

0.044

0.507

(0.005 to 0.036)

0.019

Renal CCr*

0.616

(0.043 to 2.458)

0.044

–

–

–

  1. p-values less than 0.05 are indicated in bold
  2. Correlation coefficient refers to Pearson's correlation coefficient
  3. PD peritoneal dialysis, HD hemodialysis
  4. *Compared with data at each time point (3, 6, and 12 months). Multivariable model adjusted for serum albumin, baseline beta 2 microglobulin, and blood flow rate of HD session
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Renal Replacement Therapy

ISSN: 2059-1381

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