Fig. 2

Actual or estimated serum pregabalin levels with/without performing continuous hemodiafiltration. CHDF, continuous hemodiafiltration. The black circle indicates the actual serum pregabalin levels. The white circle indicates the estimated serum pregabalin level if the patient would not have undergone continuous hemodiafiltration. The patient’s metabolic pregabalin clearance was calculated using the serum pregabalin levels at 0 h and 2.5 h after the hospital arrival. The CHDF’s pregabalin clearance was calculated using the serum pregabalin levels of the patient and the hemofilter outlet at 7.5 h after the hospital arrival. The total pregabalin clearance during performing CHDF was the sum of the patient’s metabolic clearance and CHDF’s clearance