Table 1 Comparison of characteristics and laboratory data between the 1st–5th wave group and the 6th wave group
From: Characteristics of the 6th Japanese wave of COVID-19 in hemodialysis patients
1st–5th wave group | 6th wave group | p values | |
|---|---|---|---|
Gender (M/F) | 38/9 | 44/9 | NS |
Age (year) | 59.7 ± 12.9 | 63.6 ± 12.8 | NS |
Dialysis vintage (year) | 6.6 ± 6.0 | 8.2 ± 7.8 | NS |
Days from onset to test for diagnosis (days) | 1.3 ± 2.3 | 0.9 ± 1.2 | NS |
Days from onset to hospitalization (days) | 3.4 ± 2.8 | 3.0 ± 2.4 | NS |
Primary cause of ESKD, n (%) | |||
Chronic glomerulonephritis | 10 (21.3) | 13 (24.5) | NS |
Diabetic nephropathy | 21 (44.7) | 21 (39.6) | NS |
Nephrosclerosis | 5 (10.6) | 8 (15.1) | NS |
Polycystic kidney disease | 2 (4.3) | 7 (13.2) | NS |
Unknown and others | 9 (19.1) | 4 (7.5) | NS |
Complication, n (%) | |||
Diabetes mellitus | 22 (46.8) | 22 (41.5) | NS |
Ischemic heart disease | 5 (7.5) | 11 (8.5) | NS |
Cerebrovascular disease | 8 (17.0) | 5 (9.4) | NS |
Chronic respiratory disease | 1 (2.1) | 0 (0) | NS |
Critical limb ischemia | 5 (10.6) | 5 (9.4) | NS |
Hypertension | 46 (97.9) | 50 (94.3) | NS |
Dry weight (kg) | 64.8 ± 17.7 | 64.4 ± 15.4 | NS |
Body mass index (kg/m2) | 23.2 ± 4.9 | 23.6 ± 4.7 | NS |
Number of vaccinations, n (%) | |||
0 dose | 42 (89.4) | 2 (3.8) | < 0.0001 |
More than one dose | 5 (10.6) | 51 (96.2) | < 0.0001 |
2 doses (primary series) or more | 4 (8.5) | 51 (96.2) | < 0.0001 |
3 doses (booster) | 0 (0) | 10 (18.9) | 0.001 |
Symptom at admission, n (%) | |||
Cough | 29 (61.7) | 37 (69.8) | NS |
Sore throat | 5 (10.6) | 32 (60.4) | < 0.0001 |
Headache | 12 (25.5) | 5 (9.4) | 0.032 |
Nasal discharge | 8 (17.0) | 14 (26.4) | NS |
Nausea/vomiting | 8 (17.0) | 3 (5.7) | NS |
Diarrhea | 8 (17.0) | 4 (7.5) | NS |
Olfactory and taste abnormalities | 5 (10.6) | 3 (5.7) | NS |
Blood sample | |||
Days from the onset to blood sampling (days) | 4.4 ± 2.5 | 3.2 ± 2.6 | 0.024 |
Total protein (g/dL) | 6.4 ± 0.6 | 6.7 ± 0.8 | 0.029 |
Albumin (g/dL) | 3.3 ± 0.4 | 3.6 ± 0.5 | 0.007 |
Aspartate aminotransferase (U/L) | 21 ± 10 | 19 ± 12 | NS |
Alanine aminotransferase (U/L) | 14 ± 8 | 15 ± 11 | NS |
Lactate dehydrogenase (U/L) | 285 ± 83 | 238 ± 70 | 0.003 |
Creatine kinase (U/L) | 184 ± 191 | 139 ± 136 | NS |
Urea nitrogen (mg/dL) | 64.1 ± 20.5 | 55.8 ± 17.2 | 0.032 |
Creatinine (mg/dL) | 11.9 ± 4.4 | 10.5 ± 3.8 | NS |
Ferritin (ng/ml) | 286.6 ± 280.92 | 265.4 ± 257.3 | NS |
C-reactive protein (mg/dL)* | 6.10 (1.18–10.43) | 1.98 (0.55–5.21) | 0.001 |
Hemoglobin (g/dL) | 11.2 ± 1.5 | 11.1 ± 1.6 | NS |
White blood cells (/μL) | 5000 ± 2000 | 5200 ± 2500 | NS |
Lymphocytes (%) | 15.9 ± 7.8 | 17.9 ± 7.3 | NS |
Lymphocytes (/μL) | 750 ± 370 | 860 ± 350 | NS |
Platelet (×104/μL) | 15.1 ± 4.4 | 16.7 ± 7.6 | NS |
D-dimer (μg/mL) | 2.8 ± 3.9 | 4.2 ± 10.6 | NS |
Maximum CRP level during hospitalization (mg/dL)* | 10.42 (5.22–14.12) | 1.99 (0.57–6.24) | < 0.0001 |