Time after treatment initiation | |||||||||
---|---|---|---|---|---|---|---|---|---|
Baseline | 4 weeks | 12 weeks | 24 weeks | 36 weeks | 52 weeks | 76 weeks | 104 weeks | ||
Serum ferritin [ng/mL] | |||||||||
Patients with heart failure | |||||||||
HD | n | 135 | 93 | 82 | 56 | 71 | 63 | 57 | 50 |
Absolute value, median (IQR) | 44.50 (23.70, 94.60) | 63.30 (35.40, 110.10) | 83.45 (44.00, 122.00) | 107.50 (81.55, 166.00) | 115.00 (75.80, 187.00) | 112.00 (71.30, 178.00) | 121.80 (81.10, 187.00) | 133.30 (81.80, 217.00) | |
n | 80 | 75 | 50 | 59 | 56 | 46 | 40 | ||
Change from baseline, median (IQR) | 7.05 (− 6.60, 26.75) | 22.00 (4.00, 71.10) | 52.70 (25.00, 97.00) | 61.00 (30.90, 130.00) | 66.10 (12.25, 107.05) | 62.35 (25.00, 159.50) | 71.45 (22.80, 157.80) | ||
PD | n | 33 | 24 | 21 | 15 | 19 | 15 | 9 | 7 |
Absolute value, median (IQR) | 146.00 (58.40, 223.60) | 130.00 (67.00, 280.60) | 194.00 (109.00, 266.00) | 140.00 (87.00, 324.10) | 219.20 (124.90, 366.00) | 240.00 (174.00, 416.00) | 306.00 (234.00, 351.00) | 285.00 (264.20, 396.00) | |
n | 24 | 20 | 13 | 17 | 13 | 8 | 6 | ||
Change from baseline, median (IQR) | 14.00 (− 3.65, 63.05) | 88.25 (30.75, 126.50) | 84.00 (− 7.00, 116.40) | 153.00 (93.40, 216.00) | 187.00 (159.00, 206.30) | 265.00 (190.60, 402.50) | 219.50 (169.90, 273.00) | ||
ND | n | 108 | 76 | 69 | 56 | 53 | 40 | 22 | 36 |
Absolute value, median (IQR) | 91.00 (53.50, 122.30) | 107.00 (63.65, 138.35) | 124.50 (83.00, 176.90) | 130.00 (92.00, 195.50) | 138.00 (90.00, 200.00) | 146.10 (91.25, 227.35) | 165.50 (105.70, 220.00) | 141.35 (75.20, 246.00) | |
n | 63 | 62 | 47 | 47 | 37 | 16 | 31 | ||
Change from baseline, median (IQR) | 13.00 (− 11.00, 29.40) | 27.40 (6.00, 58.00) | 44.00 (10.60, 97.00) | 48.90 (9.80, 113.50) | 57.60 (23.00, 157.20) | 53.75 (45.45, 192.60) | 62.00 (24.50, 187.10) | ||
Patients without heart failure | |||||||||
HD | n | 1079 | 658 | 702 | 557 | 650 | 622 | 538 | 504 |
Absolute value, median (IQR) | 44.50 (21.10, 88.10) | 57.95 (33.50, 111.00) | 85.20 (46.00, 145.90) | 114.00 (66.00, 183.00) | 120.75 (71.40, 202.00) | 124.00 (73.50, 202.20) | 118.00 (69.00, 210.00) | 122.65 (69.80, 231.60) | |
n | 542 | 636 | 519 | 568 | 551 | 487 | 442 | ||
Change from baseline, median (IQR) | 12.55 (− 3.20, 35.00) | 26.90 (3.50, 67.00) | 52.50 (13.80, 116.20) | 63.00 (20.75, 130.25) | 65.90 (18.00, 132.80) | 61.00 (20.50, 139.50) | 65.85 (15.20, 141.00) | ||
PD | n | 139 | 90 | 81 | 72 | 73 | 68 | 53 | 41 |
Absolute value, median (IQR) | 85.60 (51.00, 158.00) | 100.30 (65.00, 163.10) | 137.70 (67.70, 193.00) | 162.95 (96.50, 284.50) | 225.00 (130.70, 296.00) | 216.00 (108.05, 345.00) | 217.30 (146.00, 340.50) | 259.00 (209.00, 415.20) | |
n | 83 | 76 | 62 | 63 | 61 | 47 | 37 | ||
Change from baseline, median (IQR) | 15.00 (− 4.00, 43.00) | 34.25 (− 2.50, 85.90) | 72.60 (27.00, 166.00) | 99.00 (51.00, 192.00) | 125.40 (51.60, 212.00) | 132.10 (63.40, 271.00) | 172.00 (112.70, 231.40) | ||
ND | n | 490 | 328 | 271 | 192 | 208 | 156 | 110 | 85 |
Absolute value, median (IQR) | 80.65 (41.00, 154.40) | 108.50 (61.35, 181.50) | 123.20 (75.00, 194.00) | 155.00 (80.70, 217.20) | 170.05 (95.60, 272.45) | 178.40 (91.10, 262.00) | 167.20 (88.70, 302.70) | 196.80 (85.00, 292.00) | |
n | 262 | 229 | 149 | 171 | 129 | 85 | 65 | ||
Change from baseline, median (IQR) | 16.00 (− 2.00, 33.80) | 30.30 (2.70, 66.90) | 49.00 (21.60, 112.10) | 87.00 (29.00, 157.00) | 90.00 (31.00, 165.00) | 98.20 (48.00, 205.6) | 113.00 (50.00, 188.10) | ||
TSAT [%] | |||||||||
Patients with heart failure | |||||||||
HD | n | 128 | 96 | 78 | 50 | 67 | 62 | 52 | 43 |
Absolute value, mean (SD) | 21.34 (13.30) | 31.26 (16.58) | 33.82 (16.68) | 35.45 (14.17) | 31.49 (11.28) | 29.68 (12.04) | 31.59 (15.21) | 28.52 (13.53) | |
n | 84 | 70 | 46 | 57 | 53 | 41 | 33 | ||
Change from baseline, mean (SD) | 9.57 (16.38) | 12.79 (15.29) | 11.33 (16.67) | 11.17 (14.71) | 8.27 (15.39) | 9.80 (16.11) | 8.24 (17.36) | ||
PD | n | 33 | 25 | 21 | 14 | 18 | 15 | 8 | 6 |
Absolute value, mean (SD) | 28.47 (11.01) | 31.62 (10.74) | 37.96 (16.97) | 35.88 (11.31) | 41.41 (12.83) | 40.99 (18.06) | 41.89 (12.55) | 39.40 (12.32) | |
n | 25 | 20 | 13 | 17 | 14 | 7 | 5 | ||
Change from baseline, mean (SD) | 4.16 (14.27) | 9.55 (17.60) | 4.92 (12.92) | 15.01 (14.77) | 16.55 (13.82) | 21.64 (12.31) | 19.10 (7.85) | ||
ND | n | 96 | 66 | 61 | 50 | 49 | 38 | 21 | 35 |
Absolute value, mean (SD) | 23.26 (13.55) | 27.51 (14.87) | 28.58 (13.99) | 29.33 (11.73) | 31.24 (12.26) | 32.42 (11.02) | 33.97 (12.81) | 28.87 (11.75) | |
n | 55 | 53 | 40 | 41 | 33 | 14 | 29 | ||
Change from baseline, mean (SD) | 7.27 (14.71) | 5.85 (13.90) | 8.22 (13.05) | 11.52 (12.32) | 15.58 (11.25) | 15.76 (12.49) | 12.29 (12.02) | ||
Patients without heart failure | |||||||||
HD | n | 1100 | 697 | 737 | 587 | 686 | 653 | 554 | 513 |
Absolute value, mean (SD) | 22.04 (11.95) | 30.22 (13.84) | 31.39 (13.10) | 32.53 (13.63) | 31.61 (11.89) | 31.84 (12.85) | 31.59 (13.00) | 31.66 (13.32) | |
n | 640 | 696 | 553 | 629 | 605 | 515 | 469 | ||
Change from baseline, mean (SD) | 8.35 (15.01) | 9.57 (14.96) | 9.40 (16.01) | 9.04 (14.13) | 9.50 (15.18) | 9.12 (14.68) | 9.36 (15.80) | ||
PD | n | 133 | 94 | 85 | 73 | 72 | 62 | 52 | 41 |
Absolute value, mean (SD) | 30.76 (14.37) | 35.72 (14.70) | 35.02 (14.86) | 37.51 (13.38) | 39.50 (12.39) | 36.78 (16.40) | 41.01 (14.61) | 36.92 (18.54) | |
n | 87 | 78 | 65 | 62 | 55 | 47 | 36 | ||
Change from baseline, mean (SD) | 5.37 (13.66) | 4.96 (15.61) | 7.68 (12.91) | 9.67 (13.71) | 7.85 (16.87) | 12.28 (15.73) | 8.19 (22.73) | ||
ND | n | 426 | 284 | 230 | 166 | 177 | 127 | 96 | 80 |
Absolute value, mean (SD) | 28.55 (12.08) | 32.36 (12.74) | 34.98 (13.05) | 35.22 (15.17) | 37.45 (15.12) | 36.64 (15.50) | 36.54 (15.74) | 35.68 (14.25) | |
n | 228 | 192 | 126 | 142 | 103 | 73 | 60 | ||
Change from baseline, mean (SD) | 2.52 (12.75) | 5.21 (13.16) | 6.77 (13.91) | 8.27 (15.50) | 8.06 (14.39) | 8.93 (17.26) | 8.01 (15.59) | ||
Serum iron [μg/dL] | |||||||||
Patients with heart failure | |||||||||
HD | n | 133 | 101 | 82 | 50 | 69 | 63 | 52 | 46 |
Absolute value, mean (SD) | 54.27 (29.50) | 76.12 (37.89) | 79.22 (34.39) | 81.18 (30.22) | 72.54 (25.60) | 68.08 (24.80) | 71.46 (28.76) | 64.22 (26.87) | |
n | 89 | 76 | 48 | 62 | 58 | 45 | 40 | ||
Change from baseline, mean (SD) | 23.29 (43.42) | 26.34 (35.78) | 22.67 (33.48) | 17.92 (33.55) | 12.19 (32.16) | 16.96 (35.16) | 10.70 (32.55) | ||
PD | n | 33 | 26 | 21 | 15 | 18 | 15 | 8 | 6 |
Absolute value, mean (SD) | 72.55 (26.98) | 78.50 (25.33) | 92.48 (36.99) | 97.53 (48.78) | 105.56 (42.69) | 102.13 (41.68) | 99.00 (28.33) | 88.33 (20.70) | |
n | 26 | 20 | 13 | 17 | 14 | 7 | 5 | ||
Change from baseline, mean (SD) | 7.12 (38.78) | 18.90 (40.43) | 14.23 (51.48) | 36.82 (41.13) | 36.00 (26.03) | 38.86 (33.83) | 33.00 (10.07) | ||
ND | n | 107 | 71 | 64 | 53 | 52 | 40 | 22 | 36 |
Absolute value, mean (SD) | 62.59 (33.44) | 73.94 (38.07) | 83.34 (35.33) | 75.60 (20.16) | 81.46 (26.46) | 83.00 (29.24) | 78.23 (33.47) | 74.36 (25.95) | |
n | 62 | 58 | 45 | 45 | 35 | 16 | 32 | ||
Change from baseline, mean (SD) | 18.42 (41.51) | 20.41 (38.13) | 19.64 (31.15) | 27.04 (30.52) | 31.40 (38.88) | 32.88 (36.70) | 22.59 (34.60) | ||
Patients without heart failure | |||||||||
HD | n | 1176 | 780 | 806 | 628 | 733 | 697 | 586 | 540 |
Absolute value, mean (SD) | 56.40 (27.36) | 76.08 (37.65) | 74.56 (30.88) | 74.69 (30.63) | 72.90 (28.32) | 72.55 (30.30) | 72.54 (31.69) | 72.24 (36.90) | |
n | 710 | 763 | 593 | 677 | 653 | 544 | 499 | ||
Change from baseline, mean (SD) | 20.39 (38.22) | 18.99 (34.83) | 16.96 (37.05) | 16.09 (34.09) | 15.33 (35.84) | 16.01 (37.40) | 15.44 (42.28) | ||
PD | n | 134 | 98 | 87 | 77 | 78 | 64 | 53 | 41 |
Absolute value, mean (SD) | 76.69 (32.23) | 90.53 (37.55) | 86.72 (37.43) | 89.36 (30.35) | 89.54 (30.88) | 84.17 (39.38) | 92.49 (31.95) | 81.29 (42.38) | |
n | 92 | 80 | 71 | 68 | 56 | 47 | 35 | ||
Change from baseline, mean (SD) | 13.15 (36.94) | 9.71 (38.99) | 14.61 (30.47) | 15.21 (33.83) | 11.48 (41.26) | 20.55 (34.79) | 8.09 (49.58) | ||
ND | n | 472 | 313 | 255 | 185 | 203 | 147 | 109 | 90 |
Absolute value, mean (SD) | 73.65 (31.92) | 79.79 (29.95) | 84.14 (29.38) | 86.34 (33.74) | 90.05 (35.07) | 86.84 (33.98) | 87.00 (34.17) | 85.77 (33.02) | |
n | 258 | 221 | 142 | 163 | 119 | 77 | 66 | ||
Change from baseline, mean (SD) | 2.42 (36.99) | 8.79 (32.04) | 13.27 (36.64) | 16.06 (40.93) | 13.08 (34.70) | 10.86 (38.46) | 12.92 (39.73) | ||
Hemoglobin [g/dL] | |||||||||
Patients with heart failure | |||||||||
HD | n | 166 | 142 | 117 | 82 | 88 | 82 | 67 | 59 |
Absolute value, mean (SD) | 10.60 (1.35) | 10.99 (1.33) | 11.60 (1.47) | 11.07 (1.25) | 11.28 (1.33) | 11.32 (1.34) | 11.15 (1.37) | 11.16 (1.26) | |
n | 142 | 117 | 82 | 88 | 82 | 67 | 59 | ||
Change from baseline, mean (SD) | 0.38 (1.27) | 0.88 (2.00) | 0.21 (1.41) | 0.56 (1.75) | 0.57 (1.69) | 0.44 (1.59) | 0.47 (1.63) | ||
PD | n | 36 | 32 | 28 | 17 | 22 | 18 | 12 | 9 |
Absolute value, mean (SD) | 10.63 (1.39) | 11.05 (1.33) | 11.54 (1.19) | 11.16 (0.75) | 10.89 (0.96) | 11.24 (1.41) | 11.33 (1.06) | 10.98 (1.16) | |
n | 32 | 28 | 17 | 22 | 18 | 12 | 9 | ||
Change from baseline, mean (SD) | 0.39 (1.31) | 0.90 (1.86) | 0.46 (1.10) | 0.33 (1.49) | 0.62 (1.66) | 0.97 (1.74) | 0.77 (1.58) | ||
ND | n | 145 | 118 | 94 | 77 | 78 | 61 | 32 | 43 |
Absolute value, mean (SD) | 10.24 (1.37) | 10.78 (1.51) | 11.15 (1.52) | 11.19 (1.67) | 11.13 (1.35) | 11.35 (1.47) | 11.33 (1.48) | 11.13 (1.41) | |
n | 118 | 94 | 76 | 77 | 61 | 32 | 43 | ||
Change from baseline, mean (SD) | 0.44 (1.26) | 0.83 (1.61) | 0.72 (1.61) | 0.64 (1.50) | 0.80 (1.79) | 0.99 (1.63) | 0.60 (1.65) | ||
Patients without heart failure | |||||||||
HD | n | 1384 | 1115 | 1026 | 861 | 903 | 838 | 692 | 635 |
Absolute value, mean (SD) | 10.68 (1.20) | 11.21 (1.24) | 11.50 (1.37) | 11.19 (1.28) | 11.18 (1.31) | 11.20 (1.17) | 11.13 (1.25) | 11.21 (1.23) | |
n | 1115 | 1021 | 855 | 898 | 831 | 688 | 630 | ||
Change from baseline, mean (SD) | 0.52 (1.05) | 0.81 (1.71) | 0.48 (1.44) | 0.46 (1.62) | 0.47 (1.46) | 0.38 (1.43) | 0.47 (1.42) | ||
PD | n | 164 | 138 | 116 | 93 | 99 | 84 | 66 | 55 |
Absolute value, mean (SD) | 10.52 (1.24) | 10.98 (1.23) | 11.35 (1.50) | 11.30 (1.42) | 11.07 (1.26) | 11.13 (1.30) | 11.38 (1.27) | 11.24 (1.29) | |
n | 137 | 116 | 93 | 98 | 84 | 66 | 55 | ||
Change from baseline, mean (SD) | 0.48 (1.17) | 0.90 (1.57) | 0.56 (1.57) | 0.49 (1.35) | 0.42 (1.50) | 0.75 (1.59) | 0.53 (1.58) | ||
ND | n | 774 | 579 | 450 | 341 | 332 | 258 | 185 | 149 |
Absolute value, mean (SD) | 10.39 (1.31) | 10.72 (1.30) | 11.02 (1.47) | 10.96 (1.37) | 11.05 (1.36) | 11.15 (1.39) | 11.33 (1.38) | 11.49 (1.48) | |
n | 579 | 449 | 340 | 331 | 257 | 185 | |||
Change from baseline, mean (SD) | 0.33 (1.01) | 0.55 (1.43) | 0.50 (1.41) | 0.61 (1.45) | 0.52 (1.54) | 0.66 (1.54) | 0.77 (1.79) |