Patients with heart failure | Patients without heart failure | |||||
---|---|---|---|---|---|---|
HD | PD | ND | HD | PD | ND | |
Safety-analysis set, n | 166 | 36 | 146 | 1401 | 173 | 778 |
Patients with any adverse drug reaction, n (%) | 34 (20.48) | 16 (44.44) | 20 (13.70) | 289 (20.63) | 35 (20.23) | 131 (16.84) |
Number of adverse drug reactions | 49 | 23 | 25 | 396 | 44 | 163 |
Adverse drug reactions, n (%) | ||||||
Diarrhea | 2 (1.20) | 3 (8.33) | 6 (4.11) | 54 (3.85) | 10 (5.78) | 36 (4.63) |
Serum ferritin increased | 6 (3.61) | 4 (11.11) | 2 (1.37) | 43 (3.07) | 10 (5.78) | 29 (3.73) |
Constipation | 0 (0.00) | 2 (5.56) | 3 (2.05) | 28 (2.00) | 1 (0.58) | 11 (1.41) |
Hemoglobin increased | 2 (1.20) | 0 (0.00) | 1 (0.68) | 31 (2.21) | 0 (0.00) | 0 (0.00) |
Nausea | 1 (0.60) | 0 (0.00) | 0 (0.00) | 18 (1.28) | 1 (0.58) | 10 (1.29) |
Hyperferritinemia | 1 (0.60) | 2 (5.56) | 1 (0.68) | 10 (0.71) | 3 (1.73) | 8 (1.03) |
Hypertension | 1 (0.60) | 1 (2.78) | 0 (0.00) | 11 (0.79) | 1 (0.58) | 3 (0.39) |
Abdominal discomfort | 1 (0.60) | 0 (0.00) | 0 (0.00) | 11 (0.79) | 0 (0.00) | 3 (0.39) |
Abdominal distension | 2 (1.20) | 0 (0.00) | 0 (0.00) | 7 (0.50) | 0 (0.00) | 3 (0.39) |
Feces discolored | 1 (0.60) | 0 (0.00) | 0 (0.00) | 11 (0.79) | 0 (0.00) | 0 (0.00) |
Polycythemia | 2 (1.20) | 0 (0.00) | 0 (0.00) | 10 (0.71) | 0 (0.00) | 0 (0.00) |
Decreased appetite | 0 (0.00) | 0 (0.00) | 1 (0.68) | 5 (0.36) | 1 (0.58) | 3 (0.39) |
Pruritus | 0 (0.00) | 0 (0.00) | 0 (0.00) | 5 (0.36) | 0 (0.00) | 3 (0.39) |
Vomiting | 0 (0.00) | 0 (0.00) | 0 (0.00) | 7 (0.50) | 1 (0.58) | 0 (0.00) |
Feces soft | 0 (0.00) | 0 (0.00) | 0 (0.00) | 6 (0.43) | 0 (0.00) | 2 (0.26) |
Abdominal pain | 1 (0.60) | 0 (0.00) | 1 (0.68) | 3 (0.21) | 1 (0.58) | 1 (0.13) |
Hepatic function abnormal | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 2 (1.16) | 3 (0.39) |
Blood iron increased | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 1 (0.58) | 2 (0.26) |
Gastroesophageal reflux disease | 0 (0.00) | 0 (0.00) | 1 (0.68) | 3 (0.21) | 1 (0.58) | 0 (0.00) |
Red blood cell count increased | 1 (0.60) | 0 (0.00) | 0 (0.00) | 4 (0.29) | 0 (0.00) | 0 (0.00) |
Renal impairment | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 5 (0.64) |
Hyperphosphatemia | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 2 (0.26) |
Hypocalcemia | 0 (0.00) | 0 (0.00) | 2 (1.37) | 1 (0.07) | 1 (0.58) | 0 (0.00) |
Abdominal pain upper | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 1 (0.58) | 1 (0.13) |
Acute myocardial infarction | 0 (0.00) | 0 (0.00) | 0 (0.00) | 3 (0.21) | 0 (0.00) | 0 (0.00) |
Anemia | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 1 (0.13) |
Arrhythmia | 0 (0.00) | 0 (0.00) | 2 (1.37) | 1 (0.07) | 0 (0.00) | 0 (0.00) |
Back pain | 1 (0.60) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Blood calcium decreased | 1 (0.60) | 1 (2.78) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 0 (0.00) |
Cardiac failure congestive | 0 (0.00) | 0 (0.00) | 1 (0.68) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Cerebral infarction | 0 (0.00) | 0 (0.00) | 0 (0.00) | 3 (0.21) | 0 (0.00) | 0 (0.00) |
Death | 0 (0.00) | 1 (2.78) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Feeling abnormal | 1 (0.60) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Hematocrit increased | 1 (0.60) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Hemoglobin decreased | 2 (1.20) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 0 (0.00) |
Headache | 1 (0.60) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Hyperuricemia | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 1 (0.13) |
Hypophosphatemia | 1 (0.60) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Malaise | 0 (0.00) | 1 (2.78) | 0 (0.00) | 1 (0.07) | 1 (0.58) | 0 (0.00) |
Shunt occlusion | 1 (0.60) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Blood phosphorus increased | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 1 (0.58) | 0 (0.00) |
Transferrin saturation increased | 0 (0.00) | 0 (0.00) | 0 (0.00) | 3 (0.21) | 0 (0.00) | 0 (0.00) |
Nephrogenic anemia | 1 (0.60) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Abdominal pain lower | 1 (0.60) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 0 (0.00) |
Angina pectoris | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Arthralgia | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Blood parathyroid hormone increased | 0 (0.00) | 1 (2.78) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.13) |
Blood pressure decreased | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Blood pressure increased | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Bronchitis | 1 (0.60) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 0 (0.00) |
Cerebellar infarction | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Eosinophilia | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.26) |
Frequent bowel movements | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Gastric ulcer | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Gastrointestinal disorder | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Hypercholesterolemia | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 0 (0.00) | 1 (0.13) |
Insomnia | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Muscle spasms | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 1 (0.58) | 0 (0.00) |
Musculoskeletal pain | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Nasopharyngitis | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Oedema | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.26) |
Pain in extremity | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Peritonitis | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (0.07) | 1 (0.58) | 0 (0.00) |
Stomatitis | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Shunt stenosis | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (0.14) | 0 (0.00) | 0 (0.00) |
Peripheral arterial occlusive disease | 2 (1.20) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) |