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  1. Content type: Research

    Peripheral artery disease (PAD) is not only a serious complication but also a risk factor to predict prognosis in the patients with hemodialysis (HD). Ankle-brachial blood pressure index (ABI) has been widely ...

    Authors: Nanami Kida, Shunro Ageta, Yasunori Tsujimoto, Kiyoko Maehara, Masayuki Nagahara, Yoshinosuke Hamada and Nariaki Matsuura

    Citation: Renal Replacement Therapy 2016 2:66

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  2. Content type: Review

    Mineralocorticoid receptor (MR) antagonists are known to have beneficial effects in patients with cardiovascular disease without renal failure. However, there have been few published studies on the effectivene...

    Authors: Mitsuhiro Tawada, Yasuhiro Suzuki, Fumiko Sakata, Masashi Mizuno and Yasuhiko Ito

    Citation: Renal Replacement Therapy 2016 2:64

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  3. Content type: Research

    Therapeutic plasma exchange (TPE) is an important treatment modality for various diseases, but its use can be restricted by allergic reactions (AR). The aim of our study was to elucidate the frequency of and r...

    Authors: Mikako Hisamichi, Hiroo Kawarazaki, Masato Oroku, Kayori Tsuruoka, Tsutomu Sakurada, Sayuri Shirai, Ryo Kido, Kenjiro Kimura and Yugo Shibagaki

    Citation: Renal Replacement Therapy 2016 2:67

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  4. Content type: Case Report

    Heparin-induced thrombocytopenia (HIT) is a potentially life-threatening complication of heparin anticoagulation. Recently, infection has been implicated in the development of HIT.

    Authors: Sayaka Sugioka, Yohei Doi, Takeshi Ishihara, Tetsuya Arisato, Keisuke Osaki, Kenichi Koga, Masao Koshikawa and Akira Sugawara

    Citation: Renal Replacement Therapy 2016 2:62

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  5. Content type: Position statement

    The first deceased and living donor kidney transplants were performed in 1956 and 1964 in Japan, respectively. Larger numbers of transplants were performed after the introduction of cyclosporine in 1983. After...

    Authors: Takashi Yagisawa, Makiko Mieno, Norio Yoshimura, Kenji Yuzawa and Shiro Takahara

    Citation: Renal Replacement Therapy 2016 2:68

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  6. Content type: Research

    Renal failure can cause the deterioration of glucose metabolism and increase blood glucose fluctuations, which have been reported to be a factor in the progression of vascular disorders. Little information is ...

    Authors: Naoki Washida, Takahiro Kasai, Kozi Hosoya, Hirobumi Tokuyama, Shu Wakino and Hiroshi Itoh

    Citation: Renal Replacement Therapy 2016 2:57

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  7. Content type: Case Report

    Perforation of intra-abdominal organs such as the bowel and urinary bladder is one of the most serious complications related to peritoneal dialysis catheter (PDC) insertion procedures. Such a risk increases in...

    Authors: Hiroyuki Terawaki, Naotaro Fukushima, Keiko Aoyagi, Aya Nakajima, Masaaki Nakayama and Tomokazu Karino

    Citation: Renal Replacement Therapy 2016 2:51

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  8. Content type: Case Report

    Hepatitis C virus (HCV) infection a major disorder that is not only a liver-related disease but also a cardiovascular complication in renal transplant recipient. Interferon-based therapy is a contraindication ...

    Authors: Ryoichi Miyazaki and Kyoko Miyagi

    Citation: Renal Replacement Therapy 2016 2:61

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  9. Content type: Research

    The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been shown to be a predictor of cardiovascular (CV) outcomes in the general population. The aim of this study was to determine whet...

    Authors: Ayako Hasegawa, Fumiko Kojima, Mio Ueda, Yoshiko Tanaka and Kosaku Nitta

    Citation: Renal Replacement Therapy 2016 2:60

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  10. Content type: Research

    Acute-phase patients sometimes require hemodialysis therapy without vascular access (VA) present on admission. These patients require VA creation to continue hemodialysis after discharge. The risk of early VA ...

    Authors: Akihito Tanaka, Daijo Inaguma, Yu Watanabe, Eri Ito, Naoki Kamegai, Hiroya Shimogushi, Hibiki Shinjo, Kiyomi Koike, Yasuhiro Otsuka and Asami Takeda

    Citation: Renal Replacement Therapy 2016 2:59

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  11. Content type: Research

    Erythropoietin deficiency is the major cause of anemia in hemodialysis patients. Although continuous erythropoietin receptor activator (CERA) has a long half-life and once-monthly administration is recommended...

    Authors: Shoichiro Daimon, Hiromi Nuka, Kinya Kitada, Yasunori Suzuki, Fae Kim and Mitsuhiro Kawano

    Citation: Renal Replacement Therapy 2016 2:58

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  12. Content type: Research

    Evidence remains scarce regarding the property of serum bilirubin levels as a prognostic factor for the incidence of mortality in dialysis patients. Here, we aimed to examine the association between serum bili...

    Authors: Kiwako Toya, Tetsuya Babazono, Hidekazu Murata, Ko Hanai and Yasuko Uchigata

    Citation: Renal Replacement Therapy 2016 2:52

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  13. Content type: Research

    Deterioration in walking ability characterized by slow walking speed is associated with an increased risk of mortality in patients on hemodialysis (HD), but few studies have examined the potential for walking ...

    Authors: Yoshifumi Abe, Atsuhiko Matsunaga, Ryota Matsuzawa, Kei Yoneki, Manae Harada, Takaaki Watanabe, Toshiki Kutsuna, Masahiko Kimura, Kyo Shigeta, Yasuo Takeuchi and Atsushi Yoshida

    Citation: Renal Replacement Therapy 2016 2:54

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  14. Content type: Research

    Serum uric acid concentrations have been associated with mortality in patients receiving hemodialysis. Treatment options are sometimes limited because of the accumulation of a drug and/or its metabolites. The ...

    Authors: Satoko Oyama, Chihiro Hirose, Kenichiro Hori, Katsuhiro Sugano, Jie Zhang, Miyuki Tamura and Kimio Tomita

    Citation: Renal Replacement Therapy 2016 2:56

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  15. Content type: Research

    It has been reported that the survival of hemodialysis (HD) patients is poor, and the leading cause of death is cardiovascular disease. To identify high-risk patients and treat them carefully, we developed a s...

    Authors: Haruki Itoh, Hiroshi Kawaguchi, Yoichiro Tabata, Noriyoshi Murotani, Tomoko Maeda, Hidetaka Itoh and Eiichiro Kanda

    Citation: Renal Replacement Therapy 2016 2:49

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  16. Content type: Research

    Several reports have discussed the risk factors for acute kidney injury (AKI) after thoracic aortic surgery and aortic dissection and the increased mortality in patients with AKI. However, there are few report...

    Authors: Akiko Kato, Eri Ito, Naoki Kamegai, Minami Mizutani, Hiroya Shimogushi, Akihito Tanaka, Hibiki Shinjo, Yasuhiro Otsuka, Daijo Inaguma and Asami Takeda

    Citation: Renal Replacement Therapy 2016 2:53

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  17. Content type: Case Report

    Venous hypertension is one of the critical complications of arteriovenous fistula (AV fistula). Here, we report an unusual variation of venous hypertension which was caused by retrograde outflow through a perf...

    Authors: Tadashi Kamata, Kojiro Yamamoto, Motohiro Okamura and Noriyuki Iehara

    Citation: Renal Replacement Therapy 2016 2:47

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  18. Content type: Research

    Dipeptidyl peptidase 4 (DPP4) inhibitors are very useful for the treatment of type 2 diabetes, especially to patients undergoing hemodialysis (HD). The main action of DPP4 inhibitors is to increase the concent...

    Authors: Masaki Aono and Yuzuru Sato

    Citation: Renal Replacement Therapy 2016 2:44

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  19. Content type: Review

    Accumulation of uremic toxins induces various uremia-related complications in patients with chronic kidney disease, particularly those undergoing dialysis treatment. Direct interactions of uremic toxins with o...

    Authors: Suguru Yamamoto, Junichiro James Kazama, Takuya Wakamatsu, Yoshimitsu Takahashi, Yoshikatsu Kaneko, Shin Goto and Ichiei Narita

    Citation: Renal Replacement Therapy 2016 2:43

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  20. Content type: Research

    Prolonged intermittent renal replacement therapy (PIRRT) is a growing option to treat acute kidney injury in critically ill patients, but absent pharmacokinetic data challenge optimal drug dosing. Inappropriat...

    Authors: Susan J. Lewis, Weerachai Chaijamorn, Alexander R. Shaw and Bruce A. Mueller

    Citation: Renal Replacement Therapy 2016 2:45

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  21. Content type: Research

    Oxidative stress (OS) is said to increase in hemodialysis therapy, so that the electrolyzed water-hemodialysis (EW-HD) dissolving hydrogen in hemodialysis fluid has been tried for the reduction of OS. It is re...

    Authors: Kenji Maeda, Shigehito Yoshizaki, Toshiro Iida, Tomoyoshi Terada, Seiichi Era, Keiichiro Sakashita and Hajime Arikawa

    Citation: Renal Replacement Therapy 2016 2:42

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  22. Content type: Research

    The ankle-brachial blood pressure index (ABI) is an independent predictor of mortality in hemodialysis patients. In the present study, we investigated the factors that predict changes in the ABI in hemodialysi...

    Authors: Takayuki Abe, Shigeru Otsubo, Naoki Kimata, Tomoki Okajima, Yumi Otani, Jun Murakami, Iwakazu Kaneko, Naoko Miwa, Michio Mineshima, Ken Tsuchiya, Kosaku Nitta and Takashi Akiba

    Citation: Renal Replacement Therapy 2016 2:40

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  23. Content type: Position statement

    The survey of dialysis therapy during the Great East Japan Earthquake Disaster (GEJED) highlighted the vulnerability of chronic dialysis therapy and dialysis patients to disasters. To minimize negative effects...

    Authors: Ikuto Masakane, Toshio Akatsuka, Tomoyuki Yamakawa, Yoshiharu Tsubakihara, Ryoich Ando, Tadao Akizawa, Jun Minakuchi and Kosaku Nitta

    Citation: Renal Replacement Therapy 2016 2:48

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  24. Content type: Review

    Acute kidney injury (AKI) is a renal disease that is associated with high mortality. Current treatments mostly rely on supportive therapies and do not directly target the disease. Regenerative medicine, howeve...

    Authors: Takafumi Toyohara and Kenji Osafune

    Citation: Renal Replacement Therapy 2016 2:34

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  25. Content type: Case Report

    The recurrence of glomerulonephritis (GN) is critical to the prognosis of long-term renal transplant graft survival. C3 GN is a rare GN with a poor prognosis, and there are only a few reports of recurrent case...

    Authors: Hiroko Kakita, Takafumi Miyake, Toshiyuki Komiya, Tatsuo Tsukamoto and Eri Muso

    Citation: Renal Replacement Therapy 2016 2:38

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  26. Content type: Research

    Peripheral arterial disease (PAD) is a common complication in dialysis patients. Early diagnosis and treatment are recommended. Low-density lipoprotein apheresis (LDL-A) is a potential therapy to improve PAD. ...

    Authors: Kojiro Nagai, Megumi Harada, Narushi Yokota, Daigo Okada, Hiroyuki Michiwaki, Daisuke Hirose, Toshio Doi, Jun Minakuchi and Kenji Tsuchida

    Citation: Renal Replacement Therapy 2016 2:37

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  27. Content type: Review

    Onco-nephrology is a rapidly growing field that has recently garnered significant attention. Although the risk of developing cancer is reported to be higher in patients with end-stage renal disease (ESRD) than...

    Authors: Yuichiro Kitai, Takeshi Matsubara, Taro Funakoshi, Takahiro Horimatsu, Manabu Muto and Motoko Yanagita

    Citation: Renal Replacement Therapy 2016 2:33

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  28. Content type: Research

    The interaction between arbekacin and the hemodialysis membrane is unclear. The aim of this study was to evaluate the adsorption of arbekacin (ABK) onto hemodialysis membranes and to establish a simpler system...

    Authors: Motoki Urata, Yuki Narita, Daisuke Kadowaki, Kazutaka Tanoue, Issei Tashiro, Masaki Fukunaga, Akitomo Shibata, Yutaka Yoshida, Kazuaki Soejima and Sumio Hirata

    Citation: Renal Replacement Therapy 2016 2:35

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  29. Content type: Review

    Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease and also increases the incidence of cerebrovascular disease. Prevention and management of cerebrovascular disease in patien...

    Authors: Kazuhiko Tsuruya and Kiichiro Fujisaki

    Citation: Renal Replacement Therapy 2016 2:29

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  30. Content type: Review

    It is generally accepted that renal hypoxia plays an important role in the progression of chronic kidney disease (CKD). This review focuses on renal hypoxia and hypoxia-inducible factor (HIF), a master regulat...

    Authors: Shinji Tanaka, Tetsuhiro Tanaka and Masaomi Nangaku

    Citation: Renal Replacement Therapy 2016 2:25

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  31. Content type: Research

    Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become widely used in hemodialysis patients with type 2 diabetes mellitus (T2DM). This study aimed at testing the hypothesis that administration of alogliptin, a...

    Authors: Shinya Kawamoto, Ryo Koda, Yuji Imanishi, Atsunori Yoshino and Tetsuro Takeda

    Citation: Renal Replacement Therapy 2016 2:39

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  32. Content type: Research

    Erythropoiesis-stimulating agents, for example epoetin beta pegol which is a continuous erythropoietin receptor activator (CERA), and darbepoetin alfa (DPO), are recently introduced into clinical practice for ...

    Authors: Jun Sawa, Masaaki Inaba, Koichi Noguchi, Chie Nakagawa, Mayuko Kuwamura, Yukinobu Kuwamura, Noritsugu Wada, Kayoko Kitatani, Yuji Kawaguchi and Yasuro Kumeda

    Citation: Renal Replacement Therapy 2016 2:26

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  33. Content type: Review

    The annual incidence of acute kidney injury (AKI) has been increasing as the population ages. Despite advances in critical care and dialysis technology, the mortality remains unacceptably high in patients with...

    Authors: Shigeo Negi, Daisuke Koreeda, Sou Kobayashi, Yu Iwashita and Takashi Shigematu

    Citation: Renal Replacement Therapy 2016 2:31

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  34. Content type: Research

    Adverse reactions, such as anaphylactoid shock, have been reported to occur frequently with the use of polysulfone (PSf) membrane dialyzers. Polyvinylpyrrolidone (PVP) elution from the membrane may be a key fa...

    Authors: Jun Murakami, Iwakazu Kaneko, Naoki Kimata, Michio Mineshima and Takashi Akiba

    Citation: Renal Replacement Therapy 2016 2:36

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  35. Content type: Research

    Inguinal hernia is common in dialysis patients, especially peritoneal dialysis (PD) patients; however, no previous reports have assessed the incidence, type, treatments, and risk factors of inguinal hernia in ...

    Authors: Masataka Banshodani, Hideki Kawanishi, Misaki Moriishi, Sadanori Shintaku, Shinji Hashimoto and Masahiro Nishihara

    Citation: Renal Replacement Therapy 2016 2:24

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  36. Content type: Case Report

    Kocuria kristinae is an aerobic Gram-positive coccus that is considered ubiquitous and non-pathogenic in healthy individuals. Furthermore, only 27 reports have described cases of criti...

    Authors: Taro Horino, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue and Yoshio Terada

    Citation: Renal Replacement Therapy 2016 2:32

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  37. Content type: Research

    Guidelines have recommended that physicians screen for coronary artery disease (CAD) at the initiation of dialysis. The purpose of this study was to examine the effects of CAD screening at the initiation of di...

    Authors: Yuri Tanaka, Nobuhiko Joki, Toshihide Hayashi, Masaki Iwasaki, Shun Kubo, Takasuke Asakawa, Ai Matsukane, Mari Horie, Yasunori Takahashi, Hiroki Niikura, Koichi Hirahata, Yoshihiko Imamura and Hiroki Hase

    Citation: Renal Replacement Therapy 2016 2:22

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  38. Content type: Research

    Pruritus in hemodialysis patients is a serious complication that lowers quality of life and adversely affects survival. Hemodialysis-associated pruritus has multiple causes and treatments; however, no effectiv...

    Authors: Naoko Takahashi, Taku Yoshizawa, Junko Kumagai, Hideki Kawanishi, Misaki Moriishi, Takao Masaki and Shinichiro Tsuchiya

    Citation: Renal Replacement Therapy 2016 2:27

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  39. Content type: Review

    Fibroblast growth factor 23 (FGF23) is a bone-derived hormone regulating phosphate and vitamin D metabolism. FGF23 works by binding to Klotho-FGF receptor (FGFR) complex. FGF23 reduces serum phosphate level by...

    Authors: Yuichi Takashi and Seiji Fukumoto

    Citation: Renal Replacement Therapy 2016 2:20

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  40. Content type: Research

    In chronic kidney disease (CKD), the patients on a low-protein diet are considered to be at high risk of protein-energy wasting. Furthermore, a low-protein diet conceivably results in reduced intake of various...

    Authors: Yoshie Kanazawa, Shunsuke Morita, Hirofumi Sonoki and Toshiyuki Nakao

    Citation: Renal Replacement Therapy 2016 2:18

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  41. Content type: Research

    Lanthanum carbonate (LC), an effective phosphate (P) binder, is widely used to manage hyperphosphatemia in hemodialysis patients. However, the long-term safety of LC treatment in clinical practice has not been...

    Authors: Takashi Shigematsu, Shigeo Negi and Masaki Ohya

    Citation: Renal Replacement Therapy 2016 2:30

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  42. Content type: Research

    Linagliptin, the only bile-excreted dipeptidyl peptidase-4 (DPP-4) inhibitor, is a therapeutic drug for patients with diabetes receiving hemodialysis, for whom inflammation is a prognosis-related factor, becau...

    Authors: Yuya Nakamura, Hitomi Hasegawa, Mayumi Tsuji, Tatsunori Oguchi, Masatomo Mihara, Hiroki Suzuki, Kazumasa Nishida, Michiyasu Inoue, Tatsuo Shimizu, Isao Ohsawa, Hiromichi Gotoh, Yoshikazu Goto, Masahiro Inagaki and Katsuji Oguchi

    Citation: Renal Replacement Therapy 2016 2:17

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