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  1. Content type: Review

    Accumulation of uremic toxins induces various uremia-related complications in patients with chronic kidney disease, particularly those undergoing dialysis treatment. Direct interactions of uremic toxins with o...

    Authors: Suguru Yamamoto, Junichiro James Kazama, Takuya Wakamatsu, Yoshimitsu Takahashi, Yoshikatsu Kaneko, Shin Goto and Ichiei Narita

    Citation: Renal Replacement Therapy 2016 2:43

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  2. Content type: Research

    Prolonged intermittent renal replacement therapy (PIRRT) is a growing option to treat acute kidney injury in critically ill patients, but absent pharmacokinetic data challenge optimal drug dosing. Inappropriat...

    Authors: Susan J. Lewis, Weerachai Chaijamorn, Alexander R. Shaw and Bruce A. Mueller

    Citation: Renal Replacement Therapy 2016 2:45

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  3. Content type: Research

    Oxidative stress (OS) is said to increase in hemodialysis therapy, so that the electrolyzed water-hemodialysis (EW-HD) dissolving hydrogen in hemodialysis fluid has been tried for the reduction of OS. It is re...

    Authors: Kenji Maeda, Shigehito Yoshizaki, Toshiro Iida, Tomoyoshi Terada, Seiichi Era, Keiichiro Sakashita and Hajime Arikawa

    Citation: Renal Replacement Therapy 2016 2:42

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  4. Content type: Research

    The ankle-brachial blood pressure index (ABI) is an independent predictor of mortality in hemodialysis patients. In the present study, we investigated the factors that predict changes in the ABI in hemodialysi...

    Authors: Takayuki Abe, Shigeru Otsubo, Naoki Kimata, Tomoki Okajima, Yumi Otani, Jun Murakami, Iwakazu Kaneko, Naoko Miwa, Michio Mineshima, Ken Tsuchiya, Kosaku Nitta and Takashi Akiba

    Citation: Renal Replacement Therapy 2016 2:40

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  5. Content type: Position statement

    The survey of dialysis therapy during the Great East Japan Earthquake Disaster (GEJED) highlighted the vulnerability of chronic dialysis therapy and dialysis patients to disasters. To minimize negative effects...

    Authors: Ikuto Masakane, Toshio Akatsuka, Tomoyuki Yamakawa, Yoshiharu Tsubakihara, Ryoich Ando, Tadao Akizawa, Jun Minakuchi and Kosaku Nitta

    Citation: Renal Replacement Therapy 2016 2:48

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  6. Content type: Review

    Acute kidney injury (AKI) is a renal disease that is associated with high mortality. Current treatments mostly rely on supportive therapies and do not directly target the disease. Regenerative medicine, howeve...

    Authors: Takafumi Toyohara and Kenji Osafune

    Citation: Renal Replacement Therapy 2016 2:34

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  7. Content type: Case Report

    The recurrence of glomerulonephritis (GN) is critical to the prognosis of long-term renal transplant graft survival. C3 GN is a rare GN with a poor prognosis, and there are only a few reports of recurrent case...

    Authors: Hiroko Kakita, Takafumi Miyake, Toshiyuki Komiya, Tatsuo Tsukamoto and Eri Muso

    Citation: Renal Replacement Therapy 2016 2:38

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  8. Content type: Research

    Peripheral arterial disease (PAD) is a common complication in dialysis patients. Early diagnosis and treatment are recommended. Low-density lipoprotein apheresis (LDL-A) is a potential therapy to improve PAD. ...

    Authors: Kojiro Nagai, Megumi Harada, Narushi Yokota, Daigo Okada, Hiroyuki Michiwaki, Daisuke Hirose, Toshio Doi, Jun Minakuchi and Kenji Tsuchida

    Citation: Renal Replacement Therapy 2016 2:37

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  9. Content type: Review

    Onco-nephrology is a rapidly growing field that has recently garnered significant attention. Although the risk of developing cancer is reported to be higher in patients with end-stage renal disease (ESRD) than...

    Authors: Yuichiro Kitai, Takeshi Matsubara, Taro Funakoshi, Takahiro Horimatsu, Manabu Muto and Motoko Yanagita

    Citation: Renal Replacement Therapy 2016 2:33

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  10. Content type: Research

    The interaction between arbekacin and the hemodialysis membrane is unclear. The aim of this study was to evaluate the adsorption of arbekacin (ABK) onto hemodialysis membranes and to establish a simpler system...

    Authors: Motoki Urata, Yuki Narita, Daisuke Kadowaki, Kazutaka Tanoue, Issei Tashiro, Masaki Fukunaga, Akitomo Shibata, Yutaka Yoshida, Kazuaki Soejima and Sumio Hirata

    Citation: Renal Replacement Therapy 2016 2:35

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  11. Content type: Review

    Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease and also increases the incidence of cerebrovascular disease. Prevention and management of cerebrovascular disease in patien...

    Authors: Kazuhiko Tsuruya and Kiichiro Fujisaki

    Citation: Renal Replacement Therapy 2016 2:29

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  12. Content type: Review

    It is generally accepted that renal hypoxia plays an important role in the progression of chronic kidney disease (CKD). This review focuses on renal hypoxia and hypoxia-inducible factor (HIF), a master regulat...

    Authors: Shinji Tanaka, Tetsuhiro Tanaka and Masaomi Nangaku

    Citation: Renal Replacement Therapy 2016 2:25

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  13. Content type: Research

    Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become widely used in hemodialysis patients with type 2 diabetes mellitus (T2DM). This study aimed at testing the hypothesis that administration of alogliptin, a...

    Authors: Shinya Kawamoto, Ryo Koda, Yuji Imanishi, Atsunori Yoshino and Tetsuro Takeda

    Citation: Renal Replacement Therapy 2016 2:39

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  14. Content type: Research

    Erythropoiesis-stimulating agents, for example epoetin beta pegol which is a continuous erythropoietin receptor activator (CERA), and darbepoetin alfa (DPO), are recently introduced into clinical practice for ...

    Authors: Jun Sawa, Masaaki Inaba, Koichi Noguchi, Chie Nakagawa, Mayuko Kuwamura, Yukinobu Kuwamura, Noritsugu Wada, Kayoko Kitatani, Yuji Kawaguchi and Yasuro Kumeda

    Citation: Renal Replacement Therapy 2016 2:26

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  15. Content type: Review

    The annual incidence of acute kidney injury (AKI) has been increasing as the population ages. Despite advances in critical care and dialysis technology, the mortality remains unacceptably high in patients with...

    Authors: Shigeo Negi, Daisuke Koreeda, Sou Kobayashi, Yu Iwashita and Takashi Shigematu

    Citation: Renal Replacement Therapy 2016 2:31

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  16. Content type: Research

    Adverse reactions, such as anaphylactoid shock, have been reported to occur frequently with the use of polysulfone (PSf) membrane dialyzers. Polyvinylpyrrolidone (PVP) elution from the membrane may be a key fa...

    Authors: Jun Murakami, Iwakazu Kaneko, Naoki Kimata, Michio Mineshima and Takashi Akiba

    Citation: Renal Replacement Therapy 2016 2:36

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  17. Content type: Research

    Inguinal hernia is common in dialysis patients, especially peritoneal dialysis (PD) patients; however, no previous reports have assessed the incidence, type, treatments, and risk factors of inguinal hernia in ...

    Authors: Masataka Banshodani, Hideki Kawanishi, Misaki Moriishi, Sadanori Shintaku, Shinji Hashimoto and Masahiro Nishihara

    Citation: Renal Replacement Therapy 2016 2:24

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  18. Content type: Case Report

    Kocuria kristinae is an aerobic Gram-positive coccus that is considered ubiquitous and non-pathogenic in healthy individuals. Furthermore, only 27 reports have described cases of criti...

    Authors: Taro Horino, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue and Yoshio Terada

    Citation: Renal Replacement Therapy 2016 2:32

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  19. Content type: Research

    Guidelines have recommended that physicians screen for coronary artery disease (CAD) at the initiation of dialysis. The purpose of this study was to examine the effects of CAD screening at the initiation of di...

    Authors: Yuri Tanaka, Nobuhiko Joki, Toshihide Hayashi, Masaki Iwasaki, Shun Kubo, Takasuke Asakawa, Ai Matsukane, Mari Horie, Yasunori Takahashi, Hiroki Niikura, Koichi Hirahata, Yoshihiko Imamura and Hiroki Hase

    Citation: Renal Replacement Therapy 2016 2:22

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  20. Content type: Research

    Pruritus in hemodialysis patients is a serious complication that lowers quality of life and adversely affects survival. Hemodialysis-associated pruritus has multiple causes and treatments; however, no effectiv...

    Authors: Naoko Takahashi, Taku Yoshizawa, Junko Kumagai, Hideki Kawanishi, Misaki Moriishi, Takao Masaki and Shinichiro Tsuchiya

    Citation: Renal Replacement Therapy 2016 2:27

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  21. Content type: Review

    Fibroblast growth factor 23 (FGF23) is a bone-derived hormone regulating phosphate and vitamin D metabolism. FGF23 works by binding to Klotho-FGF receptor (FGFR) complex. FGF23 reduces serum phosphate level by...

    Authors: Yuichi Takashi and Seiji Fukumoto

    Citation: Renal Replacement Therapy 2016 2:20

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  22. Content type: Research

    In chronic kidney disease (CKD), the patients on a low-protein diet are considered to be at high risk of protein-energy wasting. Furthermore, a low-protein diet conceivably results in reduced intake of various...

    Authors: Yoshie Kanazawa, Shunsuke Morita, Hirofumi Sonoki and Toshiyuki Nakao

    Citation: Renal Replacement Therapy 2016 2:18

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  23. Content type: Research

    Lanthanum carbonate (LC), an effective phosphate (P) binder, is widely used to manage hyperphosphatemia in hemodialysis patients. However, the long-term safety of LC treatment in clinical practice has not been...

    Authors: Takashi Shigematsu, Shigeo Negi and Masaki Ohya

    Citation: Renal Replacement Therapy 2016 2:30

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  24. Content type: Research

    Linagliptin, the only bile-excreted dipeptidyl peptidase-4 (DPP-4) inhibitor, is a therapeutic drug for patients with diabetes receiving hemodialysis, for whom inflammation is a prognosis-related factor, becau...

    Authors: Yuya Nakamura, Hitomi Hasegawa, Mayumi Tsuji, Tatsunori Oguchi, Masatomo Mihara, Hiroki Suzuki, Kazumasa Nishida, Michiyasu Inoue, Tatsuo Shimizu, Isao Ohsawa, Hiromichi Gotoh, Yoshikazu Goto, Masahiro Inagaki and Katsuji Oguchi

    Citation: Renal Replacement Therapy 2016 2:17

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  25. Content type: Review

    Diabetic nephropathy (DN) not only is a major cause of end-stage renal disease (ESRD) in developing and developed countries but also plays a critical role as a risk factor for cardiovascular disease. The patho...

    Authors: Daiji Kawanami, Keiichiro Matoba and Kazunori Utsunomiya

    Citation: Renal Replacement Therapy 2016 2:16

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  26. Content type: Research

    Activation of vitamin D is severely impaired in patients with advanced stages of chronic kidney disease, particularly those on hemodialysis. Observational studies have shown that the use of vitamin D receptor ...

    Authors: Tetsuo Shoji, Masaaki Inaba and Yoshiki Nishizawa

    Citation: Renal Replacement Therapy 2016 2:19

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  27. Content type: Review

    Many issues regarding the management of renal replacement therapy (RRT) in acute kidney injury (AKI) including timing of initiation, selection of RRT modality, and optimal dosing remain to be resolved. Two maj...

    Authors: Teruhiko Yoshida, Yohei Komaru, Ryo Matsuura, Yoshihisa Miyamoto, Kohei Yoshimoto, Eisei Noiri, Masaomi Nangaku, Naoki Yahagi and Kent Doi

    Citation: Renal Replacement Therapy 2016 2:13

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  28. Content type: Research

    In chronic kidney disease patients, angiotensin receptor blockers (ARBs) have been known to increase serum potassium (K) levels. On the other hand, it has been reported that in patients on maintenance dialysis...

    Authors: Kiyotsugu Omae, Tetsuya Ogawa, Masao Yoshikawa, Hiroshi Sakura and Kosaku Nitta

    Citation: Renal Replacement Therapy 2016 2:14

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  29. Content type: Research

    The baseline levels of serum procalcitonin (PCT) have not been determined in patients with end-stage renal disease needing renal replacement therapy. The purpose of the present study is to verify the reference...

    Authors: Koji Ichihara, Toshiaki Tanaka, Satoshi Takahashi, Masanori Matsukawa, Masahiro Yanase, Hiroshi Kitamura and Naoya Masumori

    Citation: Renal Replacement Therapy 2016 2:9

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  30. Content type: Research

    Needle insertion pain associated with maintenance hemodialysis (HD) causes considerable stress on HD patients with native arteriovenous fistula. Skin cooling has been suggested to modify pain sensitivity and r...

    Authors: Toshihiro Torato, Masao Iwagami, Hiroshi Kawaguchi, Toshiaki Suzuki, Noriyuki Yamamoto, Shigeki Matsuo, Chiduru Ishikawa, Daisuke Katagiri, Yoshifumi Hamasaki, Norio Hanafusa, Masaomi Nangaku, Tsutomu Sanaka and Eisei Noiri

    Citation: Renal Replacement Therapy 2016 2:6

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  31. Content type: Research

    Hemodialysis (HD) patients who are resistant to erythropoiesis-stimulating agents (ESAs) have a higher mortality rate. The aim of this study was to assess the relationship between the time-dependent variabilit...

    Authors: Shunji Shiohira, Ken Tsuchiya, Hiroshi Kataoaka, Masayuki Okazaki, Mizuki Komatsu, Toshiaki Naganuma, Hiroshi Kawaguchi and Kosaku Nitta

    Citation: Renal Replacement Therapy 2016 2:10

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  32. Content type: Research

    The goal of the present study was to explore the differences in effects between erythropoiesis-stimulating agent (ESA) types on hemoglobin (Hb) level at the initiation of maintenance dialysis.

    Authors: Takasuke Asakawa, Yasuhiro Komatsu, Ryoichi Ando, Nobuhiko Joki, Yuri Tanaka, Masaki Iwasaki, Hiroki Hase, Masato Ikeda, Daijo Inaguma, Toshifumi Sakaguchi, Toshio Shinoda, Fumihiko Koiwa, Shigeo Negi, Toshihiko Yamaka and Takashi Shigematsu

    Citation: Renal Replacement Therapy 2016 2:12

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  33. Content type: Review

    Because hemodialysis therapy cannot be performed without the cannulation of a vascular access, establishing a well-functioning vascular access is crucial. Recently, the number of patients with difficult arteri...

    Authors: Tadashi Kamata, Mayumi Tomita and Noriyuki Iehara

    Citation: Renal Replacement Therapy 2016 2:7

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  34. Content type: Research

    Japan has relatively low incidence rates of renal replacement therapy (RRT) for end-stage kidney disease (ESKD) among those aged 0–19 years, but relatively high rates for the older age band. On the other hand,...

    Authors: Minako Wakasugi, Junichiro James Kazama and Ichiei Narita

    Citation: Renal Replacement Therapy 2016 2:5

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  35. Content type: Research

    Glycated albumin (GA) has been reported to be a better indicator of glycemic control than hemoglobin A1c (HbA1c) in diabetic hemodialysis (HD) patients.

    Authors: Yuki Tsuruta, Akiko Ichikawa, Kan Kikuchi, Yoshihisa Echida, Takako Onuki and Kosaku Nitta

    Citation: Renal Replacement Therapy 2016 2:3

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  36. Content type: Research

    Peritonitis is the main cause of withdrawal from peritoneal dialysis (PD) therapy in Japan. The precise extent of PD-associated peritonitis in Japan has not been investigated since 2005; we aimed to clarify th...

    Authors: Chieko Higuchi, Minoru Ito, Ikuto Masakane and Hiroshi Sakura

    Citation: Renal Replacement Therapy 2016 2:2

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  37. Content type: Case Report

    Perirenal hematomas are most frequently caused by neoplasm, followed by polyarteritis nodosa (PN), but may also be a rare complication of MPA.

    Authors: Yuri Nakashima, Maki Ohura, Toru Mima, Asuka Masumoto, Masaki Ohya, Shigeo Negi and Takashi Shigematsu

    Citation: Renal Replacement Therapy 2015 1:8

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  38. Content type: Research

    The nutritional status of patients on maintenance hemodialysis (MHD) is a strong predictor of their survival. We assessed the reliability of a protein-energy wasting (PEW) score as a predictor of the survival ...

    Authors: Sonomi Kobayashi, Keiko Suzuki, Mio Ueda, Yoshiko Tanaka and Kosaku Nitta

    Citation: Renal Replacement Therapy 2015 1:1

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  39. Content type: Review

    In blood purification therapies for critical care, there are no guidelines for selecting modalities of the treatment or for determining the treatment schedule, treatment time, and operating conditions, such as...

    Authors: Michio Mineshima

    Citation: Renal Replacement Therapy 2015 1:5

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  40. Content type: Review

    As a result of the advances in computers, data collection has become easy. The huge amount of data now available through computers is called big data. The characteristics of big data are represented by three V...

    Authors: Eiichiro Kanda

    Citation: Renal Replacement Therapy 2015 1:4

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