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Table 3 Clinical characteristics of patients (MTHFR C677T genotype)

From: Maintenance of activities of daily living despite risk from genetic polymorphism in hemodialysis patients under nutritional management who survived an average of 30 years

  

Genotype

Variable

 

CC

CT

TT

 
  

(n = 23) 29.5 %

(n = 34) 43.6 %

(n = 21) 26.9 %

P value

Age

years

62.7 ± 6.9a

63.6 ± 8.7

63.2 ± 8.7

0.920

Gender(Male/Female)

n

11/12

10/29

10/11

0.261

Duration of hemodialysis

years

28.0 (25.0-31.0)b

31 (27.0-34.3)

32.0 (28.5-35.0)

0.276

Age at initiation of hemodialysis

years

33.0 ± 7.3

32.7 ± 8.5

31.3 ± 8.2

0.760

Height

cm

159.7 ± 9.1

155.7 ± 8.1

158.5 ± 7.5

0.170

Dry weight(DW)

kg

50.0d (43.8-59.5)

44.0e (39.1-50.9)

52.6d (44.5-59.3)

0.014*

Body mass index(BMI)

kg/m2

20.2 ± 19.7

18.8 ± 2.8

20.5 ± 2.6

0.050

 BMI<18.5

n (%)

7 (21.9 %)c

19 (59.4 %)

6 (18.8 %)

 

 18.5≦BMI<25

n (%)

15 (35.7 %)

14(33.3 %)

13 (31.0 %)

 

 25≦BMI

n (%)

1 (25.0 %)

1 (25.0 %)

2 (50.0 %)

 

Bathel Index(BADL)

 

90 (74-100)

98 (84-100)

85 (78-100)

0.253

 BADL(independent/some help is necessary/with help)

n

20/2/1

33/1/0

18/1/2

<0.001*

Geriatric nutrition risk index(GNRI)

 

9489-90

9088-96

9491-99

0.200

 ≧GNRI 91(without risk of malnutrition)

n(%)

16 (34.8 %)

15 (32.6 %)

15 (32.6 %)

 

 <GNRI　91(with risk of malnutrition)

n(%)

7 (21.9 %)

19 (59.4 %)

6 (18.8 %)

 

Biochemical parameter

 

 serum albumin (Alb)

g/dL

3.7 ± 0.3

3.8 ± 0.3

3.7 ± 0.3

0.887

 total protein　(TP)

g/dL

6.4d ± 0.3

6.6 ± 0.5

6.7e ± 0.5

0.045*

 blood urea nitrogen (BUN)

mg/dL

63.8 ± 14

64.2 ± 6.6

67.6 ± 21.2

0.718

 serum creatinine (Cr)

mg/dL

10.8 ± 2.3

10.5 ± 2.2

10.8 ± 2.2

0.873

 urea acid (UA)

mg/dL

7.1 ± 1.3

6.9 ± 1.7

7.5 ± 1.5

0.341

 serum sodium (Na)

mEq/L

141 ± 2

140 ± 2.6

140 ± 2.9

0.847

 serum potassium (K)

mEq/L

5.1 ± 0.6

5.2 ± 0.7

5.1 ± 0.6

0.864

 serum inorganic phosphorus (IP)

mg/dL

5.7 ± 1.1

5.1 ± 1.2

5.6 ± 1.8

0.164

 serum calcium (Ca)

mg/dL

8.9 ± 0.7

9.3 ± 0.7

9 ± 0.6

0.096

 Hemoglobin (Hb)

g/dL

10.4 (9.1-11.5)

10.3 (10.1-11.7)

10.2 (9.5-11.1)

0.789

 Hematocrit (Ht)

%

33.5 ± 4.3

32.9 ± 3.3

32.7 ± 2.9

0.164

 serum folate

ng/mL

4.7d (4.3-5.6)

4.7d (3.8-6.0)

3.9e (3.2-4.5)

0.005*

 serum homocystein　(Hcy)

μmol/L

30.5d (25.2-37.6)

25.1d (22.1-36.9)

35.4e (27.3-58.3)

0.029*

 serum vitaminB12 (VB12)

pmol/L

545 (314-1200)

630 (383-1328)

456 (291-1463)

0.763

  1. Abbreviations: MTHFR Methylene tetrahydrofolate reductase, BMI body mass index, GNRI geriatric nutrition risk index, BADL Barthel index
  2. aValues are means ± Standard deviation(all such values)
  3. bValues are median(25th and 75th percentiles)(all such values)
  4. cValues are number of all patients (%)
  5. The normality of the data was first assessed using the Shapiro-Wilks test
  6. The values are compared between the groups by the χ2 test, one-way analysis of variance and Tukey's multiple comparison test of or Games-Howell's test, and Kruskal-Wallis test and Bonferroni's multiple comparison test as appropriate. *p < 0.05
  7. d-eMultiple comparison; A different alphabet shows that there is a significant difference
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Renal Replacement Therapy

ISSN: 2059-1381

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