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Table 3 Clinical characteristics of patients (MTHFR C677T genotype)

From: Maintenance of activities of daily living despite risk from genetic polymorphism in hemodialysis patients under nutritional management who survived an average of 30 years

   Genotype
Variable   CC CT TT  
   (n = 23) 29.5 % (n = 34) 43.6 % (n = 21) 26.9 % P value
Age years 62.7 ± 6.9a 63.6 ± 8.7 63.2 ± 8.7 0.920
Gender(Male/Female) n 11/12 10/29 10/11 0.261
Duration of hemodialysis years 28.0 (25.0-31.0)b 31 (27.0-34.3) 32.0 (28.5-35.0) 0.276
Age at initiation of hemodialysis years 33.0 ± 7.3 32.7 ± 8.5 31.3 ± 8.2 0.760
Height cm 159.7 ± 9.1 155.7 ± 8.1 158.5 ± 7.5 0.170
Dry weight(DW) kg 50.0d (43.8-59.5) 44.0e (39.1-50.9) 52.6d (44.5-59.3) 0.014*
Body mass index(BMI) kg/m2 20.2 ± 19.7 18.8 ± 2.8 20.5 ± 2.6 0.050
 BMI<18.5 n (%) 7 (21.9 %)c 19 (59.4 %) 6 (18.8 %)  
 18.5≦BMI<25 n (%) 15 (35.7 %) 14(33.3 %) 13 (31.0 %)  
 25≦BMI n (%) 1 (25.0 %) 1 (25.0 %) 2 (50.0 %)  
Bathel Index(BADL)   90 (74-100) 98 (84-100) 85 (78-100) 0.253
 BADL(independent/some help is necessary/with help) n 20/2/1 33/1/0 18/1/2 <0.001*
Geriatric nutrition risk index(GNRI)   9489-90 9088-96 9491-99 0.200
 ≧GNRI 91(without risk of malnutrition) n(%) 16 (34.8 %) 15 (32.6 %) 15 (32.6 %)  
 <GNRI　91(with risk of malnutrition) n(%) 7 (21.9 %) 19 (59.4 %) 6 (18.8 %)  
Biochemical parameter  
 serum albumin (Alb) g/dL 3.7 ± 0.3 3.8 ± 0.3 3.7 ± 0.3 0.887
 total protein　(TP) g/dL 6.4d ± 0.3 6.6 ± 0.5 6.7e ± 0.5 0.045*
 blood urea nitrogen (BUN) mg/dL 63.8 ± 14 64.2 ± 6.6 67.6 ± 21.2 0.718
 serum creatinine (Cr) mg/dL 10.8 ± 2.3 10.5 ± 2.2 10.8 ± 2.2 0.873
 urea acid (UA) mg/dL 7.1 ± 1.3 6.9 ± 1.7 7.5 ± 1.5 0.341
 serum sodium (Na) mEq/L 141 ± 2 140 ± 2.6 140 ± 2.9 0.847
 serum potassium (K) mEq/L 5.1 ± 0.6 5.2 ± 0.7 5.1 ± 0.6 0.864
 serum inorganic phosphorus (IP) mg/dL 5.7 ± 1.1 5.1 ± 1.2 5.6 ± 1.8 0.164
 serum calcium (Ca) mg/dL 8.9 ± 0.7 9.3 ± 0.7 9 ± 0.6 0.096
 Hemoglobin (Hb) g/dL 10.4 (9.1-11.5) 10.3 (10.1-11.7) 10.2 (9.5-11.1) 0.789
 Hematocrit (Ht) % 33.5 ± 4.3 32.9 ± 3.3 32.7 ± 2.9 0.164
 serum folate ng/mL 4.7d (4.3-5.6) 4.7d (3.8-6.0) 3.9e (3.2-4.5) 0.005*
 serum homocystein　(Hcy) μmol/L 30.5d (25.2-37.6) 25.1d (22.1-36.9) 35.4e (27.3-58.3) 0.029*
 serum vitaminB12 (VB12) pmol/L 545 (314-1200) 630 (383-1328) 456 (291-1463) 0.763
  1. Abbreviations: MTHFR Methylene tetrahydrofolate reductase, BMI body mass index, GNRI geriatric nutrition risk index, BADL Barthel index
  2. aValues are means ± Standard deviation(all such values)
  3. bValues are median(25th and 75th percentiles)(all such values)
  4. cValues are number of all patients (%)
  5. The normality of the data was first assessed using the Shapiro-Wilks test
  6. The values are compared between the groups by the χ2 test, one-way analysis of variance and Tukey's multiple comparison test of or Games-Howell's test, and Kruskal-Wallis test and Bonferroni's multiple comparison test as appropriate. *p < 0.05
  7. d-eMultiple comparison; A different alphabet shows that there is a significant difference
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Renal Replacement Therapy

ISSN: 2059-1381

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