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  1. Case Report

    Blood purification therapies in methotrexate-induced acute kidney injury: four case reports

    Methotrexate (MTX), a folic acid antimetabolite, is administered at a high dose for the treatment of diseases such as leukemia and malignant lymphoma. Often, an effort is made to reduce the adverse effects of ...

    Emi Fujikura, Maho Akiu, Kenichiro Miyauchi, Mai Yoshida, Satoshi Aoki, Tae Yamamoto, Kaori Narumi, Noriko Yanagisawa, Takashi Nakamichi, Mariko Miyazaki, Hiroshi Sato and Sadayoshi Ito

    Renal Replacement Therapy 2017 3:48

    Published on: 23 November 2017

  2. Research

    Positive association of residual kidney function with hemoglobin level in patients on peritoneal dialysis independent of endogenous erythropoietin concentration

    How residual kidney function (RKF) functions in the prevention of anemia in peritoneal dialysis (PD) patients is unclear. In this study, we investigated the association between RKF and hemoglobin (Hb) level.

    Kazuhiko Tsuruya, Kumiko Torisu, Hisako Yoshida, Shunsuke Yamada, Shigeru Tanaka, Akihiro Tsuchimoto, Masahiro Eriguchi, Kiichiro Fujisaki, Kosuke Masutani and Takanari Kitazono

    Renal Replacement Therapy 2017 3:47

    Published on: 9 November 2017

  3. Case Report

    Severe hypoglycemia during pneumocystis pneumonia treatment associated with trimethoprim–sulfamethoxazole use in a patient on peritoneal dialysis

    Trimethoprim–sulfamethoxazole (TMP/SMX) is an essential antimicrobial agent for treating pneumocystis pneumonia (PCP). Furthermore, the risk of hypoglycemia is increased with the co-administration of sulfonylu...

    Arata Hibi, Yusuke Kuga, Chiharu Ito, Toshiyuki Miura, Satoru Kominato, Keisuke Kamiya, Keisuke Kamiya, Takahisa Kasugai and Katsushi Koyama

    Renal Replacement Therapy 2017 3:45

    Published on: 2 November 2017

  4. Research

    Efficacy and safety of plasma exchange for Kawasaki disease with coronary artery dilatation

    The treatment of Kawasaki disease is controversial when intravenous immunoglobulin therapy fails, although it typically relies on combinations of prednisolone, infliximab, cyclosporine, and plasma exchange the...

    Yusuke Kaida, Takatoshi Kambe, Shintaro Kishimoto, Yusuke Koteda, Kenji Suda, Ryo Yamamoto, Tetsurou Imai, Takuma Hazama, Yoshimi Takamiya, Ryo Shibata, Hidemi Nishida, Seiya Okuda and Kei Fukami

    Renal Replacement Therapy 2017 3:50

    Published on: 30 October 2017

  5. Research

    Effects of preoperative cinacalcet hydrochloride treatment on the operative course of parathyroidectomy and pathological changes in resected parathyroid glands

    Secondary hyperparathyroidism (SHPT) is associated with higher cardiovascular risk and mortality in patients undergoing dialysis. Cinacalcet hydrochloride (CH), which has been clinically available in Japan sin...

    Akiko Takeshima, Hiroaki Ogata, Yoshiyuki Kadokura, Yoshihiro Yamada, Kei Asakura, Tadashi Kato, Yoshinori Saito, Kantaro Matsuzaka, Go Takahashi, Masanori Kato, Masahiro Yamamoto, Hidetoshi Ito and Eriko Kinugasa

    Renal Replacement Therapy 2017 3:49

    Published on: 27 October 2017

  6. Research

    Biocompatibility and small protein permeability of hydrophilic-coated membrane dialyzer (NV) in hemodialysis patients: a pilot study

    We evaluated the biocompatibility and small protein permeability of a newly developed hydrophilic-coated membrane dialyzer (NV) compared with conventional polysulfone dialyzer (APS) for hemodialysis (HD) therapy.

    Hirotoshi Kodama, Akira Tsuji, Akihiro Fujinoki, Koujirou Ooshima, Kaori Ishizeki and Tatsuo Inoue

    Renal Replacement Therapy 2017 3:40

    Published on: 16 October 2017

  7. Review

    Frailty and mortality among dialysis patients

    Frailty is a clinical state in which there is an increase in the individual’s vulnerability to developing increased dependency and/or mortality when exposed to a stressor. Since the mean age of dialysis patien...

    Kosaku Nitta, Norio Hanafusa and Ken Tsuchiya

    Renal Replacement Therapy 2017 3:41

    Published on: 9 October 2017

  8. Case Report

    What has changed in kidney transplantation in small islands in Japan? Experience in our center

    Okinoerabu Island and Tokunoshima Island lie in the sea to the south of the Japanese mainland, about 100 km north of Okinawa and about 500 km south of Kyushu. There are no facilities that specialize in kidney ...

    Hajime Hirano, Ryoichi Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi, Takuya Tsujino, Naoki Tanda, Kenkichi Saito, Taizo Uchimoto, Naokazu Ibuki, Teruo Inamoto, Yoshihiro Tokeshi and Haruhito Azuma

    Renal Replacement Therapy 2017 3:46

    Published on: 22 September 2017

  9. Research

    Modified A-DROP score and mortality in hemodialysis patients with pneumonia

    Pneumonia is common in hemodialysis (HD) patients and has a poor prognosis, but there is little information on an accurate method for evaluating the severity of pneumonia, which is closely associated with prog...

    Makoto Harada, Takeshi Masubuchi, Kazuaki Fujii, Yukifumi Kurasawa, Tohru Ichikawa and Mamoru Kobayashi

    Renal Replacement Therapy 2017 3:39

    Published on: 8 September 2017

  10. Research

    Long-term iron accumulation in dialysis patients treated with ferric citrate hydrate: a single-center, 80-week retrospective study in Japan

    Ferric citrate hydrate (FCH), an iron-based phosphate binder, affects mineral and iron metabolism in patients with chronic kidney disease (CKD). The long-term impact of FCH on iron overload is unknown. With th...

    Maki Hiratsuka, Katsushi Koyama, Kinya Sengo, Jun Yamamoto, Aiko Narita, Chiharu Ito, Satoshi Kominato, Arata Hibi, Keisuke Kamiya, Rumi Miyahara, Junichi Fujikawa and Toshiyuki Miura

    Renal Replacement Therapy 2017 3:37

    Published on: 5 September 2017

  11. Research

    Causative organisms and outcomes of peritoneal dialysis-related peritonitis in Sarawak General Hospital, Kuching, Malaysia: a 3-year analysis

    Peritoneal dialysis peritonitis remains a significant cause of morbidity for peritoneal dialysis patients and the main reason for conversion from peritoneal dialysis to hemodialysis. As the characteristics of ...

    Vui Eng Phui, Clare Hui Hong Tan, Chee Kean Chen, Kee Hoe Lai, Kwek Foong Chew, Hock Hin Chua, Laura Lui Sian Ngu and Lawrence Wei Soon Hii

    Renal Replacement Therapy 2017 3:35

    Published on: 16 August 2017

  12. Research

    Significance of new membrane formation in peritoneal biopsies of peritoneal dialysis patients: a case–control study

    Newly formed membrane (NFM) on the peritoneal membrane proper is a unique pathological hallmark of encapsulating peritoneal sclerosis (EPS), but its definition and diagnostic significance have not been well de...

    Kazuho Honda, Chieko Hamada, Kunio Kawanishi, Masaaki Nakayama, Masanobu Miyazaki and Yasuhiko Ito

    Renal Replacement Therapy 2017 3:33

    Published on: 9 August 2017

  13. Research

    Presepsin is a potent biomarker for diagnosing skin wound infection in hemodialysis patients compared to white blood cell count, high-sensitivity C-reactive protein, procalcitonin, and soluble CD14

    The production of presepsin has been shown to be strongly related to bacterial phagocytosis. The purpose of the present study is to compare the usefulness of presepsin for diagnosing localized skin wound infec...

    Jun Shiota, Hitoshi Tagawa, Norihiko Ohura and Hitoshi Kasahara

    Renal Replacement Therapy 2017 3:31

    Published on: 2 August 2017

  14. Research

    Relationship between mortality and Geriatric Nutritional Risk Index (GNRI) at the time of dialysis initiation: a prospective multicenter cohort study

    The Geriatric Nutritional Risk Index (GNRI) is a nutritional screening method primarily developed for elderly people; it is also reported to be useful for predicting mortality in patients on maintenance dialys...

    Akihito Tanaka, Daijo Inaguma, Hibiki Shinjo, Minako Murata and Asami Takeda

    Renal Replacement Therapy 2017 3:27

    Published on: 24 July 2017

  15. Research

    A new polymethylmetacrylate membrane improves the membrane adhesion of blood components and clinical efficacy

    Hemodialysis with polymethylmetacrylate (PMMA) membrane dialyzers allows unique protein adsorption. New PMMA dialyzers should demonstrate equivalent protein adsorption, but improved hemocompatibility.

    Ikuto Masakane, Shiho Esashi, Asami Yoshida, Tetsuro Chida, Hiroaki Fujieda, Yoshiyuki Ueno and Hiroyuki Sugaya

    Renal Replacement Therapy 2017 3:32

    Published on: 17 July 2017

  16. Research

    The optimal timing of continuous renal replacement therapy according to the modified RIFLE classification in critically ill patients with acute kidney injury: a retrospective observational study

    Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is associated with high mortality in critically ill patients. However, the optimal timing to initiate CRRT in patients with AKI i...

    Jun Suzuki, Tetsu Ohnuma, Hidenori Sanayama, Kiyonori Ito, Takayuki Fujiwara, Hodaka Yamada, Alan Kawarai Lefor and Masamitsu Sanui

    Renal Replacement Therapy 2017 3:30

    Published on: 10 July 2017

  17. Research

    Association between chronic kidney disease and physical activity level in patients with ischemic heart disease

    Although it is believed that chronic kidney disease (CKD) in patients with ischemic heart disease (IHD) negatively affects physical activity after discharge, its actual influence on the physical activity of pa...

    Ryota Matsuzawa, Takashi Masuda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Shinya Tanaka, Emi Maekawa and Junya Ako

    Renal Replacement Therapy 2017 3:28

    Published on: 30 June 2017

  18. Review

    Microparticles in kidney diseases: focus on kidney transplantation

    Microparticles are small (0.1–1 μm), extracellular vesicles that are used as diagnostic and prognostics markers of kidney diseases and kidney transplantation. They contain cytoplasm and surface markers of thei...

    Fateme Shamekhi Amiri

    Renal Replacement Therapy 2017 3:24

    Published on: 23 June 2017

  19. Review

    Urinary excretion of liver-type fatty acid-binding protein reflects the severity of sepsis

    Sepsis due to microbial invasion often causes multiple organ failure (MOF), including acute kidney injury (AKI), with high mortality rates in serious cases. Hence, there is an urgent need for diagnostic biomar...

    Eiichi Sato, Atsuko Kamijo-Ikemori, Tsuyoshi Oikawa, Aya Okuda, Takeshi Sugaya, Kenjiro Kimura, Tsukasa Nakamura and Yugo Shibagaki

    Renal Replacement Therapy 2017 3:26

    Published on: 16 June 2017

  20. Review

    Psychonephrology in Japan

    Psychonephrology is the field of study encompassing nephrology, psychiatry, and psychosomatic medicine, which is based on the concept of consultation-liaison within the biopsychosocial model of mind–body unity...

    Yoichi Ohtake

    Renal Replacement Therapy 2017 3:25

    Published on: 9 June 2017

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