Articles

Intensified hemodialysis for complicated pregnancy in a primigravida with advanced maternal age: a case report with literature review focusing on appropriate hemodialysis management during pregnancy

Pregnancy in dialysis patients is rare but challenging both for nephrologists and obstetricians. Although intensified hemodialysis is effective to achieve favorable clinical outcomes in this clinical setting, ...

Authors: Hiroyuki Arai, Keita P. Mori, Hideki Yokoi, Ken Mizuta, Jumpei Ogura, Ko Suginami, Tomomi Endo, Yoshihiro Ikeda, Takeshi Matsubara, Tatsuo Tsukamoto and Motoko Yanagita

Genetic analysis diagnosed Bardet–Biedl syndrome in a patient with a clinical diagnosis of Senior–Løken syndrome

Senior–Løken syndrome (SLS) and Bardet–Biedl syndrome (BBS) are ciliopathies. SLS is characterized by retinitis pigmentosa (RP) and familial nephronophthisis, leading to end-stage kidney disease, while BBS is ...

Authors: Yuko Fujii, Hideki Matsumura, Akihiko Shirasu, Hyogo Nakakura, Satoshi Yamazaki, Naoya Morisada, Kazumoto Iijima and Akira Ashida

Hemodialysis crossover study using a relative blood volume change-guided ultrafiltration control compared with standard hemodialysis: the BV-UFC study

It has been difficult to sufficiently achieve body-fluid management using blood volume (BV) monitor during hemodialysis (HD) with constant ultrafiltration (UF) rate. Recently, a relative BV change-guided UF co...

Authors: Susumu Ookawara, Kiyonori Ito, Takayuki Uchida, Keito Tokuyama, Satoshi Kiryu, Takeshi Suganuma, Kyoko Hojyo, Haruhisa Miyazawa, Yuichiro Ueda, Chiharu Ito, Osamu Iimura, Kunihiko Yoshiya, Yoshiyuki Morishita, Norio Hanafusa and Kaoru Tabei

Kidney failure after lung transplantation in systemic scleroderma: a case report with literature review

Systemic scleroderma (SSc) involves multiple organs including the skin, the lung, the kidney, and the esophagus. Nowadays, patient life prognosis has substantially improved due to more appropriate management o...

Authors: Takashi Ishide, Hiroshi Nishi, Hiroko Ambe, Kenjiro Honda, Motonobu Nakamura, Jiro Sato, Kota Yamamoto, Masaaki Sato and Masaomi Nangaku

Long-term exposure to pemetrexed induces chronic renal dysfunction in patients with advanced and recurrent non-squamous cell lung cancer: a retrospective study

Pemetrexed (PEM) is administered over a long term to patients with non-squamous cell lung cancer as a maintenance therapy after platinum combination induction chemotherapy. Although decreased renal function ow...

Authors: Kengo Umehara, Kaori Yama, Nozomi Koike, Shintarou Takayama, Azusa Wakamoto, Tae Hatuyama, Michiya Kobayashi and Hideki Sato

Dialysis efficacy and pain levels in relation to cannulation distance using the buttonhole technique

In this study, we investigated whether there was any difference in pain and dialysis efficacy when patients who initially entered dialysis with the rope ladder technique were switched to the buttonhole technique.

Authors: Öznur Kal, Enes Duman and Ali Kal

Annual dialysis data report for 2018, JSDT Renal Data Registry: survey methods, facility data, incidence, prevalence, and mortality

The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was sent to 4458 dialysis facilities at the end of 2018; among these facilities, 4402 facilities (98.7%) responded to t...

Authors: Kosaku Nitta, Shunsuke Goto, Ikuto Masakane, Norio Hanafusa, Masatomo Taniguchi, Takeshi Hasegawa, Shigeru Nakai, Atsushi Wada, Takayuki Hamano, Junichi Hoshino, Nobuhiko Joki, Masanori Abe, Keiichi Yamamoto and Hidetomo Nakamoto

The effects of amino acid/protein supplementation in hemodialysis patients: study protocol for a systematic review and meta-analysis

Multiple factors including older age, comorbidities, inflammation, metabolic acidosis, dialysis-related hypercatabolism and anabolic resistance of skeletal muscle, extraction of circulating amino acids through...

Authors: Ryota Matsuzawa, Shohei Yamamoto, Yuta Suzuki, Yoshifumi Abe, Manae Harada, Takahiro Shimoda, Keigo Imamura, Sachi Yamabe, Haruka Ito, Shun Yoshikoshi and Atsuhiko Matsunaga

Association between modified simple protein-energy wasting (PEW) score and all-cause mortality in patients receiving maintenance hemodialysis

Protein-energy wasting (PEW) is a frequently observed complication that leads to increased mortality in hemodialysis patients. However, a multifaceted assessment of PEW by combined objective nutritional parame...

Authors: Shunsuke Yamada, Toshiaki Nakano, Shoji Tsuneyoshi, Hokuto Arase, Sho Shimamoto, Masatomo Taniguchi, Masanori Tokumoto, Hideki Hirakata, Hiroaki Ooboshi, Kazuhiko Tsuruya and Takanari Kitazono

The effect of n-back training during hemodialysis on cognitive function in hemodialysis patients: a non-blind clinical trial

Traditional vascular risk factors such as hypertension, diabetes mellitus, hyperlipidemia, cigarette smoking, and cardiovascular disease with myocardial infarction and atrial fibrillation have been linked to c...

Authors: Yuta Noguchi, Marina Ito, Mai Mushika, Takuya Ito and Naoto Kawamura

Suppression of platelet reactivity during dialysis by addition of a nitric oxide donor to the dialysis fluid

Dialysis membranes that release nitric oxide (NO) from their surface, mimicking one of the functions of endothelial cells, may suppress platelet reactivity during hemodialysis treatment. The aim of the present...

Authors: Shunichiro Urabe, Kenichi Kokubo, Hiroshi Tsukao, Kozue Kobayashi, Minoru Hirose and Hirosuke Kobayashi

Intradialytic exercise in the treatment of social frailty: a single-center prospective study—preliminary results during the unexpected COVID-19 pandemic

Social frailty—the lack of a connection to society and infrequent social activities—has been reported to be associated with future declines in physical function in elderly individuals. This study aimed to eval...

Authors: Koki Abe, Yoshinosuke Shimamura, Takuto Maeda, Yoshikazu Kato, Yasuyoshi Yoshimura, Tomomi Tanaka and Hideki Takizawa

Estimated influence of a novel biocompatible dialysis membrane on vascular events in dialysis patients with diabetic nephropathy: a prospective randomized controlled pilot study

Polysulfone (PS) dialyzers are most frequently used worldwide for chronic renal failure patients and they are produced by several manufacturers. Despite using the same materials, differences in biocompatibilit...

Authors: Mitsuru Kubo, Ryoichi Nakazawa, Kazuhiro Akiyama, Yoshiho Tsunoda, Kazumasa Kimura, Kenji Koide, Yasuhisa Matsushima, Shinji Hasegawa, Koichi Ikeda and Nakanobu Azuma

Effects of continuous renal replacement therapy with the AN69ST membrane for septic shock and sepsis-induced AKI in an infant: a case report with literature review of cytokine/mediator removal therapy in children

Septic shock is a life-threatening condition and one of the most common causes of acute kidney injury (AKI). The acrylonitrile-co-methallyl sulfonate surface-treated (AN69ST) membrane used in severe sepsis was...

Authors: Naoto Nishizaki, Riko Ueno, Yuki Nagayama, Hanako Abe, Akina Matsuda, Akira Mizutani, Kaoru Obinata, Tadaharu Okazaki and Toshiaki Shimizu

Changes in serum concentration of rilpivirine in an HIV-infected patient treated with a combination therapy of hemodialysis and peritoneal dialysis

To our knowledge, there are no preexisting reports concerning rilpivirine (RPV) removal by hemodialysis and peritoneal dialysis.

Authors: Nanako Oshiro, Kentaro Kohagura, Shoji Tsuneyoshi, Masao Tateyama, Ryo Zamami, Hitoshi Uehara, Jiro Fujita and Yusuke Ohya

Range of plasma brain natriuretic peptide (BNP) levels in hemodialysis patients at a high risk of 1-year mortality and their relationship with the nutritional status: a retrospective cohort study in one institute

Brain natriuretic peptide (BNP) levels are used as a marker of heart failure, which is the leading cause of morbidity and mortality in dialysis patients. BNP levels increase as renal function declines. The ran...

Authors: Etsuko Kumagai, Keiko Hosohata, Kazuhiro Furumachi and Shinji Takai

Evaluation of the effect of high dose intravenous vitamin C on delayed allograft function in deceased donor kidney transplantation: a preliminary report

Delayed graft function (DGF) can affect short- and long-term allograft outcomes in kidney transplant recipients. One of the pathophysiological pathways in the occurrence of DGF is ischemia-reperfusion injury (...

Authors: Mina Borran, Simin Dashti-Khavidaki, Azam Alamdari, Neda Naderi and Farzanehsadat Minoo

Rhabdomyolysis-induced acute kidney injury requiring hemodialysis after a prolonged immobilization at home in 2 morbidly obese women: case reports with literature review

Rhabdomyolysis may develop into acute kidney injury (AKI), a life-threatening complication. Obese people are at risk for rhabdomyolysis due to prolonged immobilization. However, there are only a few reports of...

Authors: Kazuhiro Sakai, Hiroki Omizo, Ryo Togashi, Yuto Hayama, Masaki Ueno, Yoshihiro Tomomitsu, Yoshikazu Nemoto, Shinichiro Asakawa, Michito Nagura, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Shunya Uchida, Shigeru Shibata and Yoshihide Fujigaki

Pembrolizumab-associated thrombotic microangiopathy in a patient with urothelial cancer: a case report and literature review

Pembrolizumab, a highly selective humanized monoclonal IgG4κ isotype antibody against PD-1, is one of the immune checkpoint inhibitors approved for treatment of various cancers. The most frequent immune-relate...

Authors: Manabu Hayata, Masaya Shimanuki, Takehiro Ko, Ryosuke Date, Ami Hamaguchi, Aki Tominaga, Rei Miura, Teruhiko Mizumoto and Masashi Mukoyama

Improvement of microcirculatory impairment in patients with predialysis chronic kidney disease after AST-120 administration

Endothelial dysfunction starts at an earlier stage in patients with chronic kidney disease (CKD), and induces macro- and microcirculatory impairments. We evaluated whether uremic toxin-lowering therapy could i...

Authors: Takayasu Ohtake, Yasuhiro Mochida, Kunihiro Ishioka, Hidekazu Moriya, Sumi Hidaka, Masahiro Hirata, Hirokazu Yamada, Hiromichi Kumagai and Shuzo Kobayashi

Percutaneous transluminal angioplasty with carbon dioxide for peripheral arterial disease after kidney transplantation: a case report with literature review

Arteriosclerosis may progress and lead to peripheral arterial disease (PAD) during the waiting period until kidney transplantation in end-stage kidney disease (ESKD) patients. Additionally, contrast-induced ne...

Authors: Masataka Banshodani, Seiji Marubayashi, Sadanori Shintaku, Tomoyasu Sato, Misaki Moriishi, Shinichiro Tsuchiya, Hideki Ohdan and Hideki Kawanishi

A case of hemodialysis and steroid therapy for carbamazepine-induced eosinophilic granulomatosis with polyangiitis: a case report with literature review

Carbamazepine-induced acute kidney injury is mainly caused by acute tubulointerstitial nephritis. Only one case of carbamazepine-induced eosinophilic granulomatosis with polyangiitis (EGPA) with acute kidney i...

Authors: Tetsuya Abe, Keiko Nishiyama, Takuya Yamazaki, Ryoma Miyasaka, Yukari Honma, Hiroshi Tominaga, Keiko Hashimoto, Takanori Masaki, Fumi Kamata, Mariko Kamata, Togo Aoyama, Takashi Sano, Yasuo Takeuchi and Shokichi Naito

Understanding Serotonin 5-HT_2A Receptors-regulated cellular and molecular Mechanisms of Chronic Kidney Diseases

Chronic kidney diseases (CKD) are an economic burden and occur worldwide in all age groups, and the advancement of kidney disease at some point leads to deregulate or influence the function of other body organ...

Authors: Gagandeep Kaur and Pawan Krishan

Successful treatment of pleuroperitoneal communication with pleurodesis using autologous blood in a patient with severe heart failure undergoing peritoneal dialysis: a case report and brief literature review

Pleuroperitoneal communication is a potential complication of peritoneal dialysis (PD). Of the various treatment strategies for pleuroperitoneal communication, successful treatment with pleurodesis using autol...

Authors: Satoru Tatematsu, Koji Hosoya and Munekazu Ryuzaki

Improvement of multiple intraperitoneal nodules resembling peritoneal cancer that developed after peritoneal dialysis-related peritonitis caused by Mycobacterium abscessus with literature review: granuloma or carcinoma

Peritonitis is a crucial complication that leads to hospitalization or even death in patients who are undergoing peritoneal dialysis (PD). The incidence of PD-related peritonitis associated with nontuberculous...

Authors: Kohsuke Terada, Tomohiro Yan, Koji Mugishima, Sayuri Kawasaki, Fumiaki Itagaki, Takehisa Yamada and Yukinao Sakai

Influence of unstable psychological condition on the quality of life of hemodialysis patients

Hemodialysis patients tend to be in “unstable psychological conditions” because of complications and physical activity restriction. This study aimed to investigate unusual psychological factors and their influ...

Authors: Junko Takahashi, Takaya Abe, Mariko Kaneko, Nariyuki Sasaki, Yumiko Takasawa, Tetsuo Kato, Tomohiko Matsuura, Jun Sugimura, Kentaro Fukumoto, Kotaro Otsuka and Wataru Obara

Efficacy and safety of elobixibat in hemodialysis patients with chronic constipation: a retrospective study

Hemodialysis patients are likely to develop constipation as a complication due to food and fluid restrictions. Elobixibat is a new laxative that inhibits the ileal bile acid transporter expressed in the termin...

Authors: Takefumi Shono and Hiroyuki Hyakutake

A hemodialysis patient with Mycobacterium avium complex pericarditis in which remarkable presepsin elevation was not accompanied by procalcitonin elevation

The application of presepsin for diagnosing infections in hemodialysis (HD) patients has not been confirmed yet. In addition, whether presepsin can detect atypical mycobacterial infection or not remains unknown.

Authors: Jun Shiota

The impact of intraperitoneal antibiotic administration in patients with peritoneal dialysis-related peritonitis: systematic review and meta-analysis

Peritonitis is a common and clinically important complication in patients receiving peritoneal dialysis (PD). Antibiotic administration is essential for PD-related peritonitis, but routes of administration hav...

Authors: Kohkichi Morimoto, Hiroyuki Terawaki, Naoki Washida, Takahiro Kasai, Yasushi Tsujimoto, Hidemichi Yuasa, Munekazu Ryuzaki, Yasuhiko Ito, Masashi Tomo and Hidetomo Nakamoto

A case report with a literature review: cerebral meningioma diagnosed by convulsion and consciousness disorder on initiating hemodialysis

Neurological symptoms sometimes occur in hemodialysis patients, with causes including cerebral infarction, cerebral hemorrhaging, meningitis, and encephalitis. Dialysis disequilibrium syndrome (DDS) is widely ...

Authors: Miki Uwatoko, Koki Tokunaga, Mako Kawano, Masahisa Kamimura, Yutaro Ibi, Masayuki Otsuka, Masato Minami, Haruhito Yoshimine, Fujio Hamada and Akio Ido

Usefulness of glycated albumin as a predictor of mortality in chronic hemodialysis patients with diabetes: a multi-center, prospective cohort study

The association of glycated albumin (GA) with mortality is unclear in chronic hemodialysis patients with diabetes. We investigated the usefulness of GA by comparing it with hemoglobin A1c (HbA1c) in this patie...

Authors: Ko Hanai, Makoto Akamatsu, Aki Fujimori, Harumichi Higashi, Yumiko Horie, Yoshiaki Itaya, Minoru Ito, Tomoko Kanamaru, Hiroshi Kawaguchi, Kan Kikuchi, Hideo Kobayashi, Machiko Komatsu, Takao Kubota, Kenichi Kudo, Satoshi Kurihara, Ikuto Masakane…

Successful treatment of direct hemoperfusion with polymyxin B-immobilized fiber for septic shock and severe acute kidney injury due to ceftriaxone-resistant Escherichia coli: a case report with literature review

Septic shock is a life-threatening condition and one of the most common causes of acute kidney injury. Polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) is used to reduce endotoxin levels in ...

Authors: Hisato Shima, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Shunji Hashizume, Nobuyuki Takamori, Megumi Harada, Yusuke Higashiguchi, Chiaki Masaki, Taro Banno, Naoki Nagasaka, Ayako Ito, Tomoko Inoue, Manabu Tashiro, Masaaki Nishitani, Kazuhiko Kawahara…

Bile cast nephropathy: when the kidneys turn yellow

Kidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can o...

Authors: Alissar El Chediak, Khaled Janom and Sahar H. Koubar

Minilaparotomy for malfunctioning peritoneal dialysis catheter by nephrologists: experiences at two centers

Catheter malfunction is one of the most important complications of peritoneal dialysis (PD). We have performed minilaparotomy for catheter repair by nephrologists. This study aimed to evaluate the effectivenes...

Authors: Tsutomu Sakurada, Kaori Kohatsu, Shohei Yamada, Hirotaka Sato, Shigeki Kojima, Kenichiro Koitabashi, Nagayuki Kaneshiro and Yugo Shibagaki

A case of septic pulmonary embolism caused by P. aeruginosa in a hemodialysis patient and review of the literature

Septic pulmonary embolism (SPE) is an uncommon but serious complication resulting from infection of the blood. Gram-positive cocci, including methicillin-susceptible Staphylococcus aureus and methicillin-resistan...

Authors: Hiroki Shimada, Mari Tanaka, Yohtaro Takami, Mariko Teragaki, Kotaro Maeda, Hirona Saita, Seira Nishikawa, Keisuke Taniguchi, Sachio Iwanari, Masaki Ikeda and Hiroya Takeoka

Topical application of mupirocin to exit sites in patients on peritoneal dialysis: a systematic review and meta-analysis of randomized controlled trials

The International Society for Peritoneal Dialysis guidelines recommends the topical application of antibiotics on the exit site for the prevention of peritoneal dialysis (PD)-related infections. However, the r...

Authors: Yoko Obata, Miho Murashima, Naohiro Toda, Shuto Yamamoto, Yoshihiro Tsujimoto, Yasushi Tsujimoto, Hiraku Tsujimoto, Hidemichi Yuasa, Munekazu Ryuzaki, Yasuhiko Ito, Tadashi Tomo and Hidetomo Nakamoto

A clinical nomogram for the prediction of early mortality in elderly patients initiating dialysis for end-stage renal disease

The number of elderly patients (> 80 years of age) with end-stage renal disease is rapidly increasing. The initiation of dialysis extends the duration of survival; however, the rate of early mortality, that wh...

Authors: Masaki Yoshida, Masanori Otsuka, Yoshikazu Watanabe, Takako Harigai, Noriyuki Sakurai, Keiko Kobatake, Hiroaki Yoshida, Satsuki Kobayashi, Takayuki Matsumoto, Tatsuhiko Sakamoto and Kazue Ueki

Glycated hemoglobin and glycated albumin in patients with diabetes undergoing hemodiafiltration

Online hemodiafiltration (OHDF), which results in high albumin leakage, is now widely used in Japan for dialysis, since the national insurance system began reimbursing its costs in 2012. Glycated albumin (GA) ...

Authors: Yukie Kitajima, Shunichiro Urabe, Takashi Hosono, Satoshi Yoshikawa, Yuzuru Sato and Toru Hyodo

Prevalence of inherited changes of uric acid levels in kidney dysfunction including stage 5 D and T: a systematic review

Familial juvenile hereditary nephropathy (FJHN) is characterized by hyperuricemia due to severely impaired urinary excretion of urate. Hereditary renal hypouricemia is an inborn error of membrane transport. Be...

Authors: Fateme Shamekhi Amiri and Zohreh Rostami

Proposal of peritoneal biopsy procedures for patients undergoing peritoneal dialysis

Prolonged peritoneal dialysis (PD) is responsible for progressive morphological changes such as deterioration of the peritoneal membrane. These changes increase the risk of encapsulating peritoneal sclerosis (...

Authors: Tohru Mizumasa, Kazuho Honda, Shigehisa Aoki, Chieko Hamada, Masanobu Miyazaki, Yasuhiko Ito, Yudo Tanno, Toshiaki Nakano and Masaaki Nakayama

Comparison of clinical effects between icodextrin and glucose solutions on outcomes of peritoneal dialysis: systematic review and meta-analysis of randomized controlled trials

Icodextrin enhances peritoneal filtration for patients on peritoneal dialysis (PD). However, clinically important outcomes have not yet been analyzed using authentic, objective statistical methods. The present...

Authors: Atsuhiro Kanno, Yasushi Tsujimoto, Takayuki Fujii, Emi Fujikura, Kimio Watanabe, Hidemichi Yuasa, Munekazu Ryuzaki, Yasuhiko Ito and Hidetomo Nakamoto

Adequacy of decision-making based on each kidney function estimation method for Japanese living kidney donor candidates: a retrospective observational study

Living kidney transplantation comprises the majority of kidney transplantations in Japan. Living kidney donors should be assured of their own health. Therefore, Japanese guidelines define the criterion of kidn...

Authors: Koji Hashimoto, Makoto Harada, Yosuke Yamada, Mitsutoshi Sugano, Tomonori Minagawa, Teruyuki Ogawa, Osamu Ishizuka and Yuji Kamijo

Can we still ignore renal replacement therapy in sub-Saharan Africa? All living beings are created equal

This review addresses the social background and renal replacement therapy in the sub-Saharan African region. We also describe the hemodialysis treatment in countries that we have supported since 2008 and the r...

Authors: Shuzo Kobayashi and Sumi Hidaka

Relationship between blood pressure response during hemodialysis and exercise tolerance or heart rate recovery measured using cardio-pulmonary exercise testing in maintenance hemodialysis patients

This study investigated the association between the blood pressure response during hemodialysis (HD) and exercise tolerance or heart rate recovery (HRR) measured with cardiopulmonary exercise testing (CPX).

Authors: Hiroki Yabe, Kenichi Kono, Ryota Shiraki, Akiho Masuda, Yoshifumi Moriyama and Hirotake Kasuga

Evaluation of fluorinated hydroxyapatite nanoparticles as an antibacterial material for catheter coating

Catheter-related infection of peritoneal dialysis (PD) is one of the serious factors of peritonitis. However, an antibacterial PD catheter has not been commercially available in Japan yet. From an infection co...

Authors: Hiroki Gyotoku, Yoshinano Azuma and Tsutomu Furuzono

Falls in systolic blood pressure during dialysis which require no nursing intervention are associated with increased patient intra-dialytic symptom self-reporting and prolonged post-dialysis recovery times

Haemodialysis (HD) patients may suffer symptoms during dialysis and take time to recover post HD. We wished to determine whether patients with symptomatic intra-dialytic hypotension (IDH), requiring nursing in...

Authors: Suree Yoowannakul, Surachet Vongsanim, Kamonwan Tangvoraphonkchai, Ahmed Mohamed and Andrew Davenport

A new assessment scale for post-dialysis fatigue in hemodialysis patients

Authors: Hirotoshi Kodama, Taisuke Togari, Yusuke Konno, Akira Tsuji, Akihiro Fujinoki, Saburou Kuwabara and Tatsuo Inoue

Annual dialysis data report 2017, JSDT Renal Data Registry

The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was conducted for 4413 dialysis facilities at the end of 2017; among which 4360 facilities (98.8%) responded to the fac...

Authors: Kosaku Nitta, Ikuto Masakane, Norio Hanafusa, Masatomo Taniguchi, Takeshi Hasegawa, Shigeru Nakai, Shunsuke Goto, Atsushi Wada, Takayuki Hamano, Junichi Hoshino, Nobuhiko Joki, Masaki Abe, Keichi Yamamoto and Hidetomo Nakamoto

A 91-year-old woman with severe aortic stenosis successfully underwent maintenance hemodialysis via arteriovenous fistula after transcatheter aortic valve implantation: a case report with literature review

Transcatheter aortic valve implantation (TAVI) has evolved to be a treatment of choice in high-risk patients with aortic stenosis (AS). However, it is not known whether TAVI is safe and beneficial for the crea...

Authors: Minoru Yasukawa, Hiroki Omizo, Kazuhiro Sakai, Sachiko Kitagawa, Takahiro Kikuyama, Masaki Yamanaka, Fumika Ochiai, Ryo Togashi, Yoshikazu Nemoto, Tatsuya Ota, Hideyuki Kawashima, Shintaro Takamura, Yusuke Watanabe, Ken Kozuma, Shigeru Shibata and Yoshihide Fujigaki

Constipation in chronic kidney disease: it is time to reconsider

Constipation is highly prevalent in patients with chronic kidney disease (CKD) and is primarily characterized by decreased intestinal motility. This chronic disorder affects the quality of life of patients. Ho...

Authors: Ryota Ikee, Kazuhiro Yano and Tomomi Tsuru