Renal Replacement Therapy

Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early detection and intervention are necessary to improve the outcomes of AKI patients.

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Low tongue pressure contributes to oral frailty. It is a condition in which the pressure between the tongue, palate, and food decreases due to a decrease in tongue muscle function.

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Chronic kidney disease is a major risk factor for dementia, but the influence of hemodialysis itself on the development of dementia remains unclear. We previously reported that non-diabetic patients on maintenance hemodialysis have preserved cognitive function; hemodialysis removes blood amyloid β (Aβ), which is a major cause of Alzheimer’s disease in the brain; and the number of Aβ deposits in the postmortem brains of hemodialysis patients was significantly less compared to that in age-matched controls not undergoing hemodialysis.

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Prof Takashi Shigematsu, Editor-in-Chief

Prof Shigematsu is currently Professor and Director of the Division of Nephrology, Department of Internal Medicine at the Wakayama Medical University School of Medicine, Japan. He is also Director of Blood purification Medicine, and Clinical Engineering at Wakayama Medical University Hospital, as well as a member of the International Society of Nephrology and the American Society of Nephrology.

His research interests focus on bone and mineral metabolism within chronic kidney disease (CKD). In addition, he has been investigating and working in fields of hemodialysis, peritoneal dialysis, blood purification medicine in acute kidney injury, kidney transplantation.