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Table 6 Laboratory parameters and vital signs of patients who continued LC use

From: Long-term observational study in Japanese hemodialysis patients who completed a 3-year clinical study of lanthanum carbonate

Parameters Start 1 year after 2 years after 3 years after 4 years after 5 years after 6 years after 7 years after 8 years after
P (mg/dL) 8.4 ± 1.3 5.0 ± 1.0*** 5.4 ± 0.9*** 5.1 ± 0.9*** 5.7 ± 0.7*** 5.7 ± 0.9*** 5.5 ± 1.3*** 6.0 ± 1.5*** 5.5 ± 1.3***
Corrected Ca (mg/dL) 9.2 ± 0.6 9.6 ± 0.6 9.6 ± 0.6 9.9 ± 0.8 9.2 ± 0.5 9.1 ± 0.6 9.2 ± 0.5 9.3 ± 0.5 9.3 ± 0.7
Intact PTH (pg/mL) 334.6 ± 164.4 319.0 ± 185.3 353.4 ± 186.2 372.2 ± 228.2 218.9 ± 141.2** 204.3 ± 136.4* 225.2 ± 126.5* 185.7 ± 111.6* 200.9 ± 133.1*
Na (mEq/L) 138.9 ± 3.4 138.9 ± 2.3 139.1 ± 3.3 139.4 ± 2.3 138.3 ± 2.3 137.7 ± 2.5 138.4 ± 3.0 137.3 ± 3.0* 138.8 ± 2.7
K (mEq/L) 5.1 ± 0.8 5.1 ± 0.7 5.3 ± 0.6 5.2 ± 0.7 5.4 ± 0.6 5.1 ± 0.7 5.4 ± 0.7 5.3 ± 0.4 5.1 ± 0.7
Cl (mEq/L) 100.4 ± 3.8 100.4 ± 3.0 100.8 ± 3.8 100.9 ± 3.4 101.9 ± 3.6 100.6 ± 3.5 101.1 ± 4.1 99.3 ± 2.9 101.2 ± 3.4
Glucose (mg/dL) 129.0 ± 62.1 121.6 ± 47.7 121.4 ± 40.9 132.6 ± 73.1 139.3 ± 63.9 125.4 ± 38.2 132.2 ± 54.8 143.4 ± 103.2 108.1 ± 34.2
CRP (mg/dL) 0.2 ± 0.2 0.2 ± 0.2 0.1 ± 0.1 0.2 ± 0.2 1.0 ± 1.7 0.8 ± 1.2 0.5 ± 0.9 0.7 ± 1.2 0.8 ± 1.2
RBC (×104/μL) 331 ± 39 348 ± 35 344 ± 28 340 ± 35 356 ± 36 380 ± 82 360 ± 30 358 ± 41 362 ± 40
WBC (/μL) 5800 ± 1229 6067 ± 1435 5856 ± 1574 6089 ± 1386 6533 ± 2061 6782 ± 2136 5911 ± 1945 6349 ± 2030 6126 ± 1841
Hb (g/dL) 10.6 ± 1.0 10.9 ± 1.0 10.6 ± 0.9 10.6 ± 1.0 11.1 ± 0.8 11.1 ± 1.0 11.0 ± 0.8 10.4 ± 1.1 11.0 ± 1.0
Ht (%) 32.0 ± 3.9 33.0 ± 2.7 32.4 ± 2.3 32.4 ± 3.2 34.3 ± 3.1 34.7 ± 3.1 34.2 ± 2.4 32.5 ± 3.1 33.8 ± 2.8
Plt (×104/μL) 21.3 ± 4.3 21.5 ± 3.2 21.0 ± 4.2 21.4 ± 4.6 22.0 ± 6.2 22.3 ± 6.1 21.3 ± 5.8 23.1 ± 5.9 21.6 ± 6.9
Serum Alb (g/dL) 4.1 ± 0.2 4.0 ± 0.2 4.1 ± 0.2 3.9 ± 0.3 3.9 ± 0.3 3.8 ± 0.2 3.9 ± 0.3 3.8 ± 0.2 3.6 ± 0.3
ALP (U/L) 238.8 ± 129.5 290.1 ± 145.1 307.2 ± 166.1 333.9 ± 216.4 228.8 ± 83.4 244.6 ± 80.7 258.1 ± 102.5 254.9 ± 99.5 270.7 ± 107.9
LDH (IU/L) 172.2 ± 33.4 165.4 ± 25.9* 170.1 ± 26.8 172.2 ± 30.3 175.4 ± 36.7 176.2 ± 35.4 189.8 ± 48.8 192.3 ± 43.0 199.1 ± 56.9
AST (U/L) 11.3 ± 6.8 10.7 ± 4.3 11.9 ± 3.4 15.2 ± 10.9 11.1 ± 3.8 13.1 ± 4.0 14.3 ± 4.5 15.6 ± 6.1 19.9 ± 19.8
ALT (U/L) 10.3 ± 5.9 9.8 ± 4.3 11.2 ± 7.2 12.5 ± 10.7 11.1 ± 9.0 12.4 ± 5.2 14.6 ± 7.4 16.1 ± 11.0 15.7 ± 9.7
γ GTP (U/L) 18.7 ± 9.7 18.5 ± 8.6 34.2 ± 63.4 29.1 ± 34.5 28.9 ± 38.8 29.4 ± 27.4 26.8 ± 19.2 27.6 ± 21.7 29.7 ± 20.8
Total bilirubin (mg/dL) 0.2 ± 0.1 0.2 ± 0.1 0.3 ± 0.1 0.2 ± 0.1 0.3 ± 0.1 0.3 ± 0.1 0.3 ± 0.1 0.2 ± 0.0 0.3 ± 0.1
Creatinine (mg/dL) 13.1 ± 1.9 13.2 ± 1.9 12.7 ± 1.9 12.3 ± 2.0 12.4 ± 1.9 12.3 ± 1.6* 11.8 ± 1.7** 11.7 ± 2.1** 11.5 ± 2.2***
Uric acid (mg/dL) 8.5 ± 1.3 8.3 ± 1.0 8.4 ± 1.0 8.1 ± 1.1 8.1 ± 1.8 8.3 ± 1.1 8.2 ± 1.4 8.2 ± 1.6 8.0 ± 1.5
BUN (mg/dL) 76.1 ± 10.5 74.6 ± 12.2 72.2 ± 13.8 66.5 ± 12.3** 69.4 ± 12.1* 72.2 ± 14.5 71.8 ± 13.2 67.2 ± 9.7** 66.7 ± 14.9*
BUN after dialysis (mg/dL) 25.8 ± 6.4 24.6 ± 5.5 22.8 ± 5.5 20.8 ± 5.4** 20.7 ± 5.8** 20.5 ± 6.8** 20.6 ± 5.8** 18.8 ± 4.7*** 18.5 ± 5.2***
TG (mg/dL) 131.6 ± 70.3 145.4 ± 86.4 156.4 ± 83.9 125.3 ± 72.5 134.5 ± 95.6 130.6 ± 69.3 114.5 ± 49.9 128.1 ± 74.7 114.3 ± 48.5
Total cholesterol (mg/dL) 175.4 ± 33.6 166.4 ± 30.9 181.1 ± 39.8 170.2 ± 31.8 157.5 ± 27.6 159.3 ± 46.5 182.4 ± 38.1 185.3 ± 40.1 176.7 ± 38.0
HDL-C (mg/dL) 44.5 ± 15.3 43.4 ± 12.6 44.3 ± 11.8 46.1 ± 13.8 52.7 ± 15.3 49.3 ± 13.1 54.5 ± 11.9 49.6 ± 12.4 50.0 ± 13.7
SBP (mmHg) 162.4 ± 23.2 160.1 ± 21.9 157.2 ± 22.8 153.3 ± 17.4** 149.8 ± 16.6* 149.5 ± 23.6** 150.9 ± 17.9* 141.3 ± 22.5** 144.2 ± 17.6**
DBP (mmHg) 92.9 ± 17.4 89.1 ± 17.5 86.4 ± 17.2** 86.8 ± 15.3* 84.9 ± 10.5* 82.6 ± 15.2*** 83.5 ± 12.5** 77.6 ± 12.9** 79.6 ± 12.6***
HR (beats/min) 78.1 ± 11.2 78.4 ± 9.9 79.1 ± 10.0 75.9 ± 9.6 77.1 ± 18.4 78.2 ± 12.0 74.7 ± 12.3 77.0 ± 14.8 76.9 ± 10.4
  1. Data are given as mean ± standard deviation (n)
  2. LC lanthanum carbonate
  3. V.S. At the start, ***P < 0.001, **P < 0.01, *P < 0.05