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Table 1 Input parameters used in in silico ciprofloxacin and levofloxacin dosing trials in PIRRT [3036]

From: In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy

  Ciprofloxacin Levofloxacin
Demographic and pharmacokinetic parameters
Weight (kg) 86.6 ± 29.2 [≥40]
Volume of distribution (L/kg) 1.25 ± 0.4 [0.5–1.92] 1.2 ± 0.4 [0.7–2.08]
Non-renal clearance (mL/min) 116 ± 61 [13–259] 25.7 ± 14 [0.12–67]
Saturation/sieving coefficient 0.7 ± 0.2 [0–1] 0.6 ± 0.2 [0–1]
PIRRT operation parameters
Modality Hemofiltration or hemodialysis
Frequency Daily
Blood flow rate 300 mL/min
Dialysate/ultrafiltration flow rate and duration 4 L/h for 10 h or 5 L/h for 8 h
  1. All values are represented as mean ± SD [assigned model limits]