Table 1 Input parameters used in in silico ciprofloxacin and levofloxacin dosing trials in PIRRT [30–36]
Ciprofloxacin | Levofloxacin | |
|---|---|---|
Demographic and pharmacokinetic parameters | ||
Weight (kg) | 86.6 ± 29.2 [≥40] | |
Volume of distribution (L/kg) | 1.25 ± 0.4 [0.5–1.92] | 1.2 ± 0.4 [0.7–2.08] |
Non-renal clearance (mL/min) | 116 ± 61 [13–259] | 25.7 ± 14 [0.12–67] |
Saturation/sieving coefficient | 0.7 ± 0.2 [0–1] | 0.6 ± 0.2 [0–1] |
PIRRT operation parameters | ||
Modality | Hemofiltration or hemodialysis | |
Frequency | Daily | |
Blood flow rate | 300 mL/min | |
Dialysate/ultrafiltration flow rate and duration | 4 L/h for 10 h or 5 L/h for 8 h | |