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Table 4 PTA sensitivity analyses of “successful” fluoroquinolone dosing recommendation with various effluent flow rates in PIRRT

From: In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy

AUC24h:MICa ≥125
8-h hemofiltration in early PIRRT
Ultrafiltrate flow rate (L/hr) Ciprofloxacin Levofloxacin
2 96 98
3 95 98
4 94 97
5b 93 97
6 93 97
7 93 97
8 93 97
9 92 96
10 92 96
  1. PTA data were from 8-h PIRRT using a 5 L/h effluent flow rate (ultrafiltrate flow rate) with blood flow rate of 300 mL/min. Similar PTA was resulted from 10-h PIRRT
  2. aMIC = 1 mg/L for ciprofloxacin and MIC = 2 mg/L for levofloxacin (susceptibility breakpoint for Pseudomonas aeruginosa)
  3. bReference flow rate used in this study