In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy

Table 4 PTA sensitivity analyses of “successful” fluoroquinolone dosing recommendation with various effluent flow rates in PIRRT

AUC_24h:MIC^a ≥125
8-h hemofiltration in early PIRRT
Ultrafiltrate flow rate (L/hr)	Ciprofloxacin	Levofloxacin
2	96	98
3	95	98
4	94	97
5^b	93	97
6	93	97
7	93	97
8	93	97
9	92	96
10	92	96

PTA data were from 8-h PIRRT using a 5 L/h effluent flow rate (ultrafiltrate flow rate) with blood flow rate of 300 mL/min. Similar PTA was resulted from 10-h PIRRT
^aMIC = 1 mg/L for ciprofloxacin and MIC = 2 mg/L for levofloxacin (susceptibility breakpoint for Pseudomonas aeruginosa)
^bReference flow rate used in this study

ISSN: 2059-1381