Characteristics | Reticulocyte count | p | ||||
---|---|---|---|---|---|---|
All Patients | Q1 | Q2 | Q3 | Q4 | ANOVA or χ 2 | |
No. of patients | 358 | 89 | 90 | 89 | 90 | |
Range of reticulocyte count (103/μL) | 9.3 to 147.9 | ≤30.1 | 30.2 to 39.4 | 39.6 to 53.6 | ≤53.7 | |
Demographics | ||||||
Age (year) | 60.2 (12.6) | 60.4 (13.8) | 60.4 (12.7) | 61.0 (12.6) | 59.1 (11.4) | 0.78 |
Male gender (%) | 67.3 | 78.7 | 70.0 | 64.0 | 56.7 | 0.01 |
Duration of dialysis (year) | 8.5 (7.0) | 7.9 (6.2) | 8.8 (6.6) | 8.8 (7.6) | 8.7 (7.4) | 0.80 |
Cause of renal failure | ||||||
Diabetes mellitus (%) | 29.9 | 23.6 | 27.8 | 33.7 | 34.4 | 0.34 |
BMI | 20.6 (3.0) | 20.0 (2.4) | 20.6 (3.0) | 20.6 (2.8) | 21.1 (3.5) | 0.09 |
Dry weight (kg) | 53.1 (10.3) | 53.0 (9.0) | 53.3 (12.1) | 52.2 (9.1) | 53.7 (10.7) | 0.80 |
Interdialysis weight gain (%) | 5.6 (1.9) | 5.1 (1.9) | 5.6 (1.9) | 5.4 (2.0) | 6.0 (1.7) | 0.02 |
Smoking history (%) | 44.9 | 48.8 | 42.9 | 45.3 | 42.5 | 0.84 |
Vascular disease history (%) | 47.8 | 41.6 | 42.2 | 53.9 | 53.3 | 0.18 |
Medication | ||||||
ACE or ARB (%) | 30.7 | 40.4 | 38.1 | 25.6 | 18.9 | <0.01 |
Injection of Fe (%) | 25.1 | 22.5 | 30.0 | 25.8 | 22.2 | 0.60 |
1w rHuEPO/week (IU/w) | 3694 (3077) | 3396 (2874) | 4321 (2949) | 3584 (3281) | 3508 (3154) | 0.19 |
2w rHuEPO/week (IU/w) | 3727 (3079) | 3459 (2906) | 4415 (2971) | 3576 (3255) | 3496 (3079) | 0.13 |
4w rHuEPO/week (IU/w) | 3752 (3063) | 3550 (2912) | 4339 (2900) | 3628 (3259) | 3521 (3142) | 0.25 |
Systolic blood pressure (mmHg) | 151.9 (23.6) | 154.8 (20.9) | 155.5 (22.4) | 146.8 (25.6) | 150.33 (24.5) | 0.05 |
Diastolic blood pressure (mmHg) | 78.4 (11.6) | 79.4 (12.1) | 80.4 (11.1) | 76.8 (10.0) | 76.9 (13.0) | 0.11 |
Laboratory parameters | ||||||
Reticulocyte count (103/μL) | 43.4 (19.4) | 22.5 (5.1) | 35.1 (2.7) | 45.8 (4.0) | 69.6 (16.1) | <0.001 |
Hemoglobin (g/dL) | 9.9 (1.1) | 9.8 (1.2) | 9.9 (1.0) | 9.8 (1.0) | 10.1 (1.2) | 0.20 |
Mean corpuscular volume (fL) | 97.8 (6.8) | 97.2 (6.3) | 98.9 (6.2) | 97.9 (7.0) | 97.0 (7.7) | 0.22 |
White cell count (103/μL) | 6.1 (2.1) | 5.4 (1.5) | 6.0 (1.8) | 6.2 (2.2) | 6.9 (2.5) | <0.001 |
Platelet count (103/μL) | 185 (67) | 172 (53) | 182 (58) | 187 (65) | 199 (87) | 0.06 |
Iron (μg/dL) | 57.2 (23.3) | 58.9 (25.9) | 60.3 (25.0) | 57.2 (20.0) | 52.6 (21.4) | 0.13 |
TSAT (%) | 21.9 (10.1) | 24.1 (11.8) | 23.0 (10.1) | 21.8 (9.1) | 18.9 (8.5) | <0.01 |
Ferritin (ng/mL) | 101 (135) | 116 (167) | 94 (107) | 108 (160) | 85 (92) | 0.43 |
AST (U/L) | 15.9 (8.8) | 15.5 (6.4) | 14.8 (6.0) | 17.2 (12.6) | 16.1 (8.5) | 0.32 |
ALT (U/L) | 14.2 (10.3) | 13.6 (7.3) | 13.7 (8.0) | 15.4 (15.9) | 14.0 (7.7) | 0.62 |
Alkaline phosphatase (U/L) | 251 (101) | 253 (115) | 249 (78) | 246 (96) | 255 (114) | 0.94 |
Total bilirubin (mg/dL) | 0.20 (0.09) | 0.21 (0.10) | 0.19 (0.06) | 0.20 (0.10) | 0.20 (0.09) | 0.60 |
Lactate dehydrogenase (U/L) | 335 (81) | 323 (70) | 322 (66) | 342 (83) | 353 (98) | 0.03 |
Blood urea nitrogen (mg/dL) | 77.4 (17.4) | 70.1 (14.5) | 80.3 (18.1) | 79.1 (18.2) | 80.1 (16.7) | <0.001 |
Creatinine (mg/dL) | 11.7 (2.8) | 11.5 (3.1) | 12.0 (2.6) | 11.5 (2.7) | 11.8 (2.7) | 0.63 |
Corrected calcium (mg/dL) | 9.30 (0.88) | 9.25 (0.84) | 9.19 (0.92) | 9.28 (0.88) | 9.48 (0.87) | 0.14 |
Phosphorus inorganic (mg/dL) | 5.95 (1.50) | 5.49 (1.42) | 5.90 (1.33) | 5.91 (1.56) | 6.43 (1.53) | <0.001 |
Parathyroid hormone intact (pg/mL) | 212 (191) | 212 (206) | 229 (172) | 198 (292) | 210 (184) | 0.75 |
Albumin (g/dL) | 3.72 (0.36) | 3.71 (0.35) | 3.80 (0.36) | 3.68 (0.76) | 3.68 (0.35) | 0.07 |
Total protein (g/dL) | 6.46 (0.51) | 6.43 (0.49) | 6.49 (0.50) | 6.43 (0.58) | 6.49 (0.50) | 0.71 |
Glucose (mg/dL) | 135 (62) | 122 (40) | 128 (47) | 141 (72) | 149 (78) | 0.01 |
Total cholesterol (mg/dL) | 157 (34) | 147 (31) | 154 (33) | 162 (31) | 165 (36) | <0.01 |
High-density lipoprotein (mg/dL) | 45 (14) | 43 (12) | 46 (14) | 46 (15) | 45 (15) | 0.43 |
Triglyceride (mg/dL) | 117 (68) | 97 (48) | 107 (62) | 120 (62) | 143 (87) | <0.001 |
Non-HDL (mg/dL) | 112.1 (32.3) | 104.2 (29.8) | 108.1 (31.1) | 116.4 (31.3) | 119.9 (34.9) | <0.01 |
C-reactive protein (mg/dL) | 0.57 (1.33) | 0.41 (0.76) | 0.45 (1.16) | 0.56 (1.23) | 0.86 (1.88) | 0.11 |
Serum erythropoietin (U/L) | 16.2 (22.8) | 11.0 (9.0) | 12.0 (8.0) | 14.7 (12.0) | 26.6 (40.4) | <0.001 |
Kt/V | 1.23 (0.25) | 1.19 (0.24) | 1.26 (0.27) | 1.24 (0.23) | 1.23 (0.24) | 0.41 |
Hb trend 0.5 mo (g/dL/week) n = 353 | −0.02 (0.39) | 0.01 (0.06) | 0.08 (0.37) | −0.03 (0.31) | −0.12 (0.44) | 0.01 |
Hb trend 6 mo (g/dL/week) n = 338 | 0.01 (0.07) | 0.03 (0.06) | 0.01 (0.06) | 0.00 (0.05) | −0.01 (0.09) | <0.01 |