No. of patients
|
358
|
89
|
90
|
89
|
90
| |
Range of reticulocyte count (103/μL)
|
9.3 to 147.9
|
≤30.1
|
30.2 to 39.4
|
39.6 to 53.6
|
≤53.7
| |
Demographics
|
Age (year)
|
60.2 (12.6)
|
60.4 (13.8)
|
60.4 (12.7)
|
61.0 (12.6)
|
59.1 (11.4)
|
0.78
|
Male gender (%)
|
67.3
|
78.7
|
70.0
|
64.0
|
56.7
|
0.01
|
Duration of dialysis (year)
|
8.5 (7.0)
|
7.9 (6.2)
|
8.8 (6.6)
|
8.8 (7.6)
|
8.7 (7.4)
|
0.80
|
Cause of renal failure
|
Diabetes mellitus (%)
|
29.9
|
23.6
|
27.8
|
33.7
|
34.4
|
0.34
|
BMI
|
20.6 (3.0)
|
20.0 (2.4)
|
20.6 (3.0)
|
20.6 (2.8)
|
21.1 (3.5)
|
0.09
|
Dry weight (kg)
|
53.1 (10.3)
|
53.0 (9.0)
|
53.3 (12.1)
|
52.2 (9.1)
|
53.7 (10.7)
|
0.80
|
Interdialysis weight gain (%)
|
5.6 (1.9)
|
5.1 (1.9)
|
5.6 (1.9)
|
5.4 (2.0)
|
6.0 (1.7)
|
0.02
|
Smoking history (%)
|
44.9
|
48.8
|
42.9
|
45.3
|
42.5
|
0.84
|
Vascular disease history (%)
|
47.8
|
41.6
|
42.2
|
53.9
|
53.3
|
0.18
|
Medication
|
ACE or ARB (%)
|
30.7
|
40.4
|
38.1
|
25.6
|
18.9
|
<0.01
|
Injection of Fe (%)
|
25.1
|
22.5
|
30.0
|
25.8
|
22.2
|
0.60
|
1w rHuEPO/week (IU/w)
|
3694 (3077)
|
3396 (2874)
|
4321 (2949)
|
3584 (3281)
|
3508 (3154)
|
0.19
|
2w rHuEPO/week (IU/w)
|
3727 (3079)
|
3459 (2906)
|
4415 (2971)
|
3576 (3255)
|
3496 (3079)
|
0.13
|
4w rHuEPO/week (IU/w)
|
3752 (3063)
|
3550 (2912)
|
4339 (2900)
|
3628 (3259)
|
3521 (3142)
|
0.25
|
Systolic blood pressure (mmHg)
|
151.9 (23.6)
|
154.8 (20.9)
|
155.5 (22.4)
|
146.8 (25.6)
|
150.33 (24.5)
|
0.05
|
Diastolic blood pressure (mmHg)
|
78.4 (11.6)
|
79.4 (12.1)
|
80.4 (11.1)
|
76.8 (10.0)
|
76.9 (13.0)
|
0.11
|
Laboratory parameters
|
Reticulocyte count (103/μL)
|
43.4 (19.4)
|
22.5 (5.1)
|
35.1 (2.7)
|
45.8 (4.0)
|
69.6 (16.1)
|
<0.001
|
Hemoglobin (g/dL)
|
9.9 (1.1)
|
9.8 (1.2)
|
9.9 (1.0)
|
9.8 (1.0)
|
10.1 (1.2)
|
0.20
|
Mean corpuscular volume (fL)
|
97.8 (6.8)
|
97.2 (6.3)
|
98.9 (6.2)
|
97.9 (7.0)
|
97.0 (7.7)
|
0.22
|
White cell count (103/μL)
|
6.1 (2.1)
|
5.4 (1.5)
|
6.0 (1.8)
|
6.2 (2.2)
|
6.9 (2.5)
|
<0.001
|
Platelet count (103/μL)
|
185 (67)
|
172 (53)
|
182 (58)
|
187 (65)
|
199 (87)
|
0.06
|
Iron (μg/dL)
|
57.2 (23.3)
|
58.9 (25.9)
|
60.3 (25.0)
|
57.2 (20.0)
|
52.6 (21.4)
|
0.13
|
TSAT (%)
|
21.9 (10.1)
|
24.1 (11.8)
|
23.0 (10.1)
|
21.8 (9.1)
|
18.9 (8.5)
|
<0.01
|
Ferritin (ng/mL)
|
101 (135)
|
116 (167)
|
94 (107)
|
108 (160)
|
85 (92)
|
0.43
|
AST (U/L)
|
15.9 (8.8)
|
15.5 (6.4)
|
14.8 (6.0)
|
17.2 (12.6)
|
16.1 (8.5)
|
0.32
|
ALT (U/L)
|
14.2 (10.3)
|
13.6 (7.3)
|
13.7 (8.0)
|
15.4 (15.9)
|
14.0 (7.7)
|
0.62
|
Alkaline phosphatase (U/L)
|
251 (101)
|
253 (115)
|
249 (78)
|
246 (96)
|
255 (114)
|
0.94
|
Total bilirubin (mg/dL)
|
0.20 (0.09)
|
0.21 (0.10)
|
0.19 (0.06)
|
0.20 (0.10)
|
0.20 (0.09)
|
0.60
|
Lactate dehydrogenase (U/L)
|
335 (81)
|
323 (70)
|
322 (66)
|
342 (83)
|
353 (98)
|
0.03
|
Blood urea nitrogen (mg/dL)
|
77.4 (17.4)
|
70.1 (14.5)
|
80.3 (18.1)
|
79.1 (18.2)
|
80.1 (16.7)
|
<0.001
|
Creatinine (mg/dL)
|
11.7 (2.8)
|
11.5 (3.1)
|
12.0 (2.6)
|
11.5 (2.7)
|
11.8 (2.7)
|
0.63
|
Corrected calcium (mg/dL)
|
9.30 (0.88)
|
9.25 (0.84)
|
9.19 (0.92)
|
9.28 (0.88)
|
9.48 (0.87)
|
0.14
|
Phosphorus inorganic (mg/dL)
|
5.95 (1.50)
|
5.49 (1.42)
|
5.90 (1.33)
|
5.91 (1.56)
|
6.43 (1.53)
|
<0.001
|
Parathyroid hormone intact (pg/mL)
|
212 (191)
|
212 (206)
|
229 (172)
|
198 (292)
|
210 (184)
|
0.75
|
Albumin (g/dL)
|
3.72 (0.36)
|
3.71 (0.35)
|
3.80 (0.36)
|
3.68 (0.76)
|
3.68 (0.35)
|
0.07
|
Total protein (g/dL)
|
6.46 (0.51)
|
6.43 (0.49)
|
6.49 (0.50)
|
6.43 (0.58)
|
6.49 (0.50)
|
0.71
|
Glucose (mg/dL)
|
135 (62)
|
122 (40)
|
128 (47)
|
141 (72)
|
149 (78)
|
0.01
|
Total cholesterol (mg/dL)
|
157 (34)
|
147 (31)
|
154 (33)
|
162 (31)
|
165 (36)
|
<0.01
|
High-density lipoprotein (mg/dL)
|
45 (14)
|
43 (12)
|
46 (14)
|
46 (15)
|
45 (15)
|
0.43
|
Triglyceride (mg/dL)
|
117 (68)
|
97 (48)
|
107 (62)
|
120 (62)
|
143 (87)
|
<0.001
|
Non-HDL (mg/dL)
|
112.1 (32.3)
|
104.2 (29.8)
|
108.1 (31.1)
|
116.4 (31.3)
|
119.9 (34.9)
|
<0.01
|
C-reactive protein (mg/dL)
|
0.57 (1.33)
|
0.41 (0.76)
|
0.45 (1.16)
|
0.56 (1.23)
|
0.86 (1.88)
|
0.11
|
Serum erythropoietin (U/L)
|
16.2 (22.8)
|
11.0 (9.0)
|
12.0 (8.0)
|
14.7 (12.0)
|
26.6 (40.4)
|
<0.001
|
Kt/V
|
1.23 (0.25)
|
1.19 (0.24)
|
1.26 (0.27)
|
1.24 (0.23)
|
1.23 (0.24)
|
0.41
|
Hb trend 0.5 mo (g/dL/week) n = 353
|
−0.02 (0.39)
|
0.01 (0.06)
|
0.08 (0.37)
|
−0.03 (0.31)
|
−0.12 (0.44)
|
0.01
|
Hb trend 6 mo (g/dL/week) n = 338
|
0.01 (0.07)
|
0.03 (0.06)
|
0.01 (0.06)
|
0.00 (0.05)
|
−0.01 (0.09)
|
<0.01
|