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Table 1 Summary of representative rodent models used to study peritoneal dialysis and its associated complications

From: Peritonitis-induced peritoneal injury models for research in peritoneal dialysis review of infectious and non-infectious models

Representative animal models   Methods Species Experimental period Peritoneal dysfunction Neoangiogenesis Fibrosis EPS References
Peritonitis model          
Infectious model Bacteria Staphylococcus aureus Mouse 2 days No report No report No report − [14]
Rat 2 weeks No report No report ± − [15,16,17,18]
   Staphylococcus epidermidis Mouse 2 weeks No report No report No report − [20]
   Pseudomonas aeruginosa Rat 1 week No report No report No report − [21]
  Fungus Candida albicans Mouse 1 day No report No report No report − [22]
  Performance without aseptic precautions   Mouse 1 week + + No report − [23]
Rat 1 week + + No report − [23,24,25]
Non-infectious model   LPS Mouse 1 day + No report No report − [26, 27]
Rat 1 day + No report No report − [28, 29]
   PDF with LPS Rat 3–6 weeks + + + − [29,30,31,32,33,34,35,36]
   SES Mouse 2 days No report No report No report − [11, 37]
   Scraping Rat 2 weeks + + + − [38, 39]
   Zymosan with scraping Rat 5 weeks No report + + ± [64, 67]
   PDF Mouse 4–5 weeks + + + − [78,79,80,81,82,83]
Rat 1–20 weeks + + + − [69,70,71,72,73,74,75,76,77]
   Chlorhexidine Mouse 1–8 weeks + + + + [97,98,99,100,101,102,103,104,105,106,107,108]
Rat 1–8 weeks + + + + [84,85,86,87,88,89,90,91,92,93,94,95,96]
   Methylglyoxal Mouse 3–7 weeks + + + + [113, 114]
Rat 3 weeks + + + + [109,110,111,112]
   TGF-β1 Mouse 1–10 weeks No report + + + [115,116,117,118]
Rat 1–4 weeks + + + − [119, 120]
  1. LPS lipopolysaccharide, PDF peritoneal dialysis fluid, SES a lyophilized cell-free supernatant, TGF-β1 transforming growth factor-β1, EPS encapsulating peritoneal sclerosis
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Renal Replacement Therapy

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