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Table 2 Baseline characteristics of the early and late CRRT groups

From: The optimal timing of continuous renal replacement therapy according to the modified RIFLE classification in critically ill patients with acute kidney injury: a retrospective observational study

  All patients Early patients Late patients P value
(n = 189) (n = 52) (n = 137)  
Baseline data
 Age (years), median (IQR) 72 (61–78) 74 (62–78) 71 (61–77) 0.37
 Gender (male), n (%) 133 (70) 36 (69) 97 (71) 0.86
 Baseline serum creatinine (mg/dl), median (IQR) 1.0 (0.7–1.5)a 1.5 (0.9–2.9)a 0.9 (0.7–1.2)a <0.001
Comorbidities
 Hypertension, n (%) 116 (61) 36 (69) 80 (58) 0.19
 Diabetes mellitus, n (%) 56 (30) 17 (33) 39 (29) 0.6
 Chronic kidney disease, n (%) 89 (47) 33 (63) 56 (41) 0.009
  Stage 2, n (%) 6 (7) 2 (4) 4 (3) 0.69
  Stage 3, n (%) 36 (40) 10 (19) 26 (19) 1
  Stage 4, n (%) 16 (18) 10 (19) 6 (4) 0.002
  Stage 5, n (%) 12 (13) 10 (19) 2 (2) <0.001
  Unknown, n (%) 19 (21) 1(2) 18(16) 0.04
 Congestive heart failure, n (%) 34 (18) 10 (19) 24 (18) 0.83
Data on admission to ICU
 Serum creatinine (mg/dl), median (IQR) 2.0 (1.2–3.4) 1.5 (1.1–2.9) 2.1 (1.3–3.5) 0.047
 Bilirubin (mg/dl), median (IQR) 0.8 (0.5–1.6) 0.8 (0.5–1.3) 0.8 (0.5–1.7) 0.42
 Platelets (cells/103), median (IQR) 146 (66–211) 124 (66–207) 146 (68–214) 0.98
 PaO2/FiO2 ratio (Torr), median (IQR) 200 (117–329) 195 (117–297) 200 (119–329) 0.91
 SAPS II, median (IQR) 57 (44–72) 57 (40–68) 57 (45–72) 0.5
 Glasgow Coma Scale, median (IQR) 14 (6–15) 14 (3–15) 14 (6–15) 0.24
  1. Abbreviations: CRRT continuous renal replacement therapy, ICU intensive care unit, IQR interquartile range, BUN blood urea nitrogen, eGFR estimated glomerular filtration rate, SAPS II Simplified Acute Physiology Score II
  2. aSixty-five, six, and fifty-nine patients with unknown baseline creatinine were not included