The optimal timing of continuous renal replacement therapy according to the modified RIFLE classification in critically ill patients with acute kidney injury: a retrospective observational study

Table 2 Baseline characteristics of the early and late CRRT groups

	All patients	Early patients	Late patients	P value
	(n = 189)	(n = 52)	(n = 137)
Baseline data
Age (years), median (IQR)	72 (61–78)	74 (62–78)	71 (61–77)	0.37
Gender (male), n (%)	133 (70)	36 (69)	97 (71)	0.86
Baseline serum creatinine (mg/dl), median (IQR)	1.0 (0.7–1.5)^a	1.5 (0.9–2.9)^a	0.9 (0.7–1.2)^a	<0.001
Comorbidities
Hypertension, n (%)	116 (61)	36 (69)	80 (58)	0.19
Diabetes mellitus, n (%)	56 (30)	17 (33)	39 (29)	0.6
Chronic kidney disease, n (%)	89 (47)	33 (63)	56 (41)	0.009
Stage 2, n (%)	6 (7)	2 (4)	4 (3)	0.69
Stage 3, n (%)	36 (40)	10 (19)	26 (19)	1
Stage 4, n (%)	16 (18)	10 (19)	6 (4)	0.002
Stage 5, n (%)	12 (13)	10 (19)	2 (2)	<0.001
Unknown, n (%)	19 (21)	1(2)	18(16)	0.04
Congestive heart failure, n (%)	34 (18)	10 (19)	24 (18)	0.83
Data on admission to ICU
Serum creatinine (mg/dl), median (IQR)	2.0 (1.2–3.4)	1.5 (1.1–2.9)	2.1 (1.3–3.5)	0.047
Bilirubin (mg/dl), median (IQR)	0.8 (0.5–1.6)	0.8 (0.5–1.3)	0.8 (0.5–1.7)	0.42
Platelets (cells/10³), median (IQR)	146 (66–211)	124 (66–207)	146 (68–214)	0.98
PaO₂/FiO₂ ratio (Torr), median (IQR)	200 (117–329)	195 (117–297)	200 (119–329)	0.91
SAPS II, median (IQR)	57 (44–72)	57 (40–68)	57 (45–72)	0.5
Glasgow Coma Scale, median (IQR)	14 (6–15)	14 (3–15)	14 (6–15)	0.24

Abbreviations: CRRT continuous renal replacement therapy, ICU intensive care unit, IQR interquartile range, BUN blood urea nitrogen, eGFR estimated glomerular filtration rate, SAPS II Simplified Acute Physiology Score II
^aSixty-five, six, and fifty-nine patients with unknown baseline creatinine were not included

ISSN: 2059-1381