|
Cardiovascular events
|
Stroke
|
---|
(/1000 patients year)
|
(/1000 patients year)
|
---|
CHOIR
|
51.7
|
5.4
|
CREATE
|
58
|
7.2
|
TREAT
|
76.4
|
9.5
|
A21
|
15.6
|
2.1
|
Gonryo (G3–5)
|
21.8
|
8.6
|
- The events defined as cardiovascular events in each study were as follows: the events specified as primary endpoints in the CHOIR, CREATE, and TREAT studies; myocardial infarction, cerebral infarction, cerebellar infarction, lung congestion, and heart failure, which were specified as adverse events, in the A21 study; angina, myocardial infarction, heart failure, and stroke in stage G3–5 patients in the Gonryo study