Table 3 Interventional studies examining effects of Mg-containing phosphate binders on cardiovascular calcification/atherosclerosis
Authors (year) | Subjects | Study design | Outcome | Serum Mg levels in the Mg group (mg/dL) | Benefits of Mg supplementation |
|---|---|---|---|---|---|
Turgut et al. (2008) [76] | 47, HD | RCT with assignment to magnesium citrate or calcium acetate for 2 months | Changes in carotid intima-media thickness evaluated by ultrasound | Pre: 2.50 ± 0.36 Post: 2.69 ± 0.39 | Yes |
Tzanakis et al. (2014) [77] | 72, HD | RCT with assignment to calcium acetate or calcium acetate/magnesium carbonate for 12 months | Changes in arterial calcification of the femur, pelvis, hands, and abdomen evaluated by plain X-ray using vascular calcification scores | Pre: 2.59 ± 0.29 Post: 2.83 ± 0.38 | Yes |