Table 2 Calcium channel blockers affecting aldosterone synthesis
From: Cardiac hypertrophy in chronic kidney disease—role of Aldosterone and FGF23
Ca channel blockers | Inhibition of Ca channel subtypes | Inhibition of aldosterone production | Mineralocorticoid receptor blockade | |||
|---|---|---|---|---|---|---|
L-type | T-type | N-type | Adrenal cells | Human plasma concentrations | ||
Nifedipine | + | + [83] | ||||
Amlodipine | + | |||||
Efonidipine | + | + | + [70] | |||
Nilvadipine | + | + | ||||
Azelnidipine | + | + | + [72] | + [77] | ||
Cilnidipine | + | + | + [73] | |||
Benidipine | + | + | + | + [71] | + [76] | + [84] |