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Table 2 Predictors of NODAT as assessed with multivariate Cox proportional hazards models

From: Serum uric acid is an independent predictor of new-onset diabetes after living-donor kidney transplantation

Variable

Univariate model

P value

Multivariate models

Model 1

P value

Model 2

P value

Model 3

P value

SUA, per 1 mg/dL

1.27 (1.04–1.55)

0.01

1.26 (1.02–1.56)

0.03

1.34 (1.10–1.64)

0.003

1.36 (1.11–1.66)

0.003

Use of diuretics (yes/no)

1.05 (0.48–2.16)

0.88

1.08 (0.50–2.63)

0.82

    

Use of allopurinol therapy (yes/no)

0.67 (0.25–1.45)

0.36

0.66 (0.24–1.53)

0.36

    

Creatinine, per 1 mg/dL

0.77 (0.55–1.01)

0.06

1.07 (0.95–1.21)

0.23

    

Sex (men)

0.77 (0.37–1.58)

0.47

  

0.73 (0.32–1.65)

0.41

  

Age, per 1 year

1.04 (1.01–1.07)

0.006

  

1.04 (1.01–1.07)

0.008

1.05 (1.02–1.08)

0.0007

BMI, per 1 kg/m2

1.00 (089–1.11)

0.88

  

0.99 (0.86–1.13)

0.94

  

Family history of diabetes (yes/no)

0.49 (0.07–1.63)

0.28

  

0.57 (0.09–1.93)

0.38

  

HbA1c, per 1%

2.39 (1.07–5.34)

0.03

  

2.06 (0.85–5.02)

0.10

  

Insulinogenic index, per 1 change

0.82 (0.47–1.09)

0.27

  

0.81 (0.43–1.18)

0.38

  

HOMA-IR, per 1 unit

1.05 (0.69–1.45)

0.76

  

0.95 (0.54–1.46)

0.84

  

Calcineurin inhibitor (tacrolimus/cyclosporin A)

1.73 (0.85–3.57)

0.12

    

1.99 (0.97–4.17)

0.05

HCV-positive (yes/no)

1.49 (0.24–4.97)

0.60

    

1.11 (0.17–3.88)

0.88

  1. Results are expressed as hazard ratios (95% confidence intervals). Cohort size n = 151 (84 men and 67 women)
  2. BMI body mass index, HbA1c haemoglobin A1c, HCV hepatitis C virus, HOMA-IR homeostasis model assessment of insulin resistance