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Table 2 Predictors of NODAT as assessed with multivariate Cox proportional hazards models

From: Serum uric acid is an independent predictor of new-onset diabetes after living-donor kidney transplantation

Variable Univariate model P value Multivariate models
Model 1 P value Model 2 P value Model 3 P value
SUA, per 1 mg/dL 1.27 (1.04–1.55) 0.01 1.26 (1.02–1.56) 0.03 1.34 (1.10–1.64) 0.003 1.36 (1.11–1.66) 0.003
Use of diuretics (yes/no) 1.05 (0.48–2.16) 0.88 1.08 (0.50–2.63) 0.82     
Use of allopurinol therapy (yes/no) 0.67 (0.25–1.45) 0.36 0.66 (0.24–1.53) 0.36     
Creatinine, per 1 mg/dL 0.77 (0.55–1.01) 0.06 1.07 (0.95–1.21) 0.23     
Sex (men) 0.77 (0.37–1.58) 0.47    0.73 (0.32–1.65) 0.41   
Age, per 1 year 1.04 (1.01–1.07) 0.006    1.04 (1.01–1.07) 0.008 1.05 (1.02–1.08) 0.0007
BMI, per 1 kg/m2 1.00 (089–1.11) 0.88    0.99 (0.86–1.13) 0.94   
Family history of diabetes (yes/no) 0.49 (0.07–1.63) 0.28    0.57 (0.09–1.93) 0.38   
HbA1c, per 1% 2.39 (1.07–5.34) 0.03    2.06 (0.85–5.02) 0.10   
Insulinogenic index, per 1 change 0.82 (0.47–1.09) 0.27    0.81 (0.43–1.18) 0.38   
HOMA-IR, per 1 unit 1.05 (0.69–1.45) 0.76    0.95 (0.54–1.46) 0.84   
Calcineurin inhibitor (tacrolimus/cyclosporin A) 1.73 (0.85–3.57) 0.12      1.99 (0.97–4.17) 0.05
HCV-positive (yes/no) 1.49 (0.24–4.97) 0.60      1.11 (0.17–3.88) 0.88
  1. Results are expressed as hazard ratios (95% confidence intervals). Cohort size n = 151 (84 men and 67 women)
  2. BMI body mass index, HbA1c haemoglobin A1c, HCV hepatitis C virus, HOMA-IR homeostasis model assessment of insulin resistance