Serum uric acid is an independent predictor of new-onset diabetes after living-donor kidney transplantation

Table 2 Predictors of NODAT as assessed with multivariate Cox proportional hazards models

Variable	Univariate model	P value	Multivariate models
Variable	Univariate model	P value	Model 1	P value	Model 2	P value	Model 3	P value
SUA, per 1 mg/dL	1.27 (1.04–1.55)	0.01	1.26 (1.02–1.56)	0.03	1.34 (1.10–1.64)	0.003	1.36 (1.11–1.66)	0.003
Use of diuretics (yes/no)	1.05 (0.48–2.16)	0.88	1.08 (0.50–2.63)	0.82
Use of allopurinol therapy (yes/no)	0.67 (0.25–1.45)	0.36	0.66 (0.24–1.53)	0.36
Creatinine, per 1 mg/dL	0.77 (0.55–1.01)	0.06	1.07 (0.95–1.21)	0.23
Sex (men)	0.77 (0.37–1.58)	0.47			0.73 (0.32–1.65)	0.41
Age, per 1 year	1.04 (1.01–1.07)	0.006			1.04 (1.01–1.07)	0.008	1.05 (1.02–1.08)	0.0007
BMI, per 1 kg/m²	1.00 (089–1.11)	0.88			0.99 (0.86–1.13)	0.94
Family history of diabetes (yes/no)	0.49 (0.07–1.63)	0.28			0.57 (0.09–1.93)	0.38
HbA1c, per 1%	2.39 (1.07–5.34)	0.03			2.06 (0.85–5.02)	0.10
Insulinogenic index, per 1 change	0.82 (0.47–1.09)	0.27			0.81 (0.43–1.18)	0.38
HOMA-IR, per 1 unit	1.05 (0.69–1.45)	0.76			0.95 (0.54–1.46)	0.84
Calcineurin inhibitor (tacrolimus/cyclosporin A)	1.73 (0.85–3.57)	0.12					1.99 (0.97–4.17)	0.05
HCV-positive (yes/no)	1.49 (0.24–4.97)	0.60					1.11 (0.17–3.88)	0.88

Results are expressed as hazard ratios (95% confidence intervals). Cohort size n = 151 (84 men and 67 women)
BMI body mass index, HbA1c haemoglobin A1c, HCV hepatitis C virus, HOMA-IR homeostasis model assessment of insulin resistance

ISSN: 2059-1381