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Table 6 Relative risk of in-hospital mortality using univariate and multivariate logistic regression models

From: Using Sepsis-3 criteria to predict prognosis of patients receiving continuous renal replacement therapy for community-acquired sepsis: a retrospective observational study

Variable In-hospital mortality
Univariate analysis Multivariate analysis
Odds ratio (95% CI) P value Odds ratio (95% CI) P value
Age ≥ 65 years 3.93 (1.36–11.3) 0.012* 3.96 (1.22–14.3) 0.021*
Male sex 0.60 (0.20–1.77) 0.41   
Hypertension 1.38 (0.51–3.77) 0.61   
Diabetes 0.27 (0.07–1.10) 0.07   
Smoking 1.44 (0.53–3.89) 0.61   
Alcoholism 0.38 (0.07–2.07) 0.45   
Positive cultures 0.47 (0.17–1.32) 0.2   
Pre-hospital antimicrobial therapy 1.93 (0.71–5.27) 0.22 2.81 (0.85–10.6) 0.093
Operation before starting CRRT 0.76 (0.25–2.30) 0.78   
PMX-DHP combination 1.44 (0.50–4.18) 0.59   
AKI at the start of CRRT 0.43 (0.14–1.35) 0.16   
Lactate ≥ 2 mmol/L 7.23 (2.23–23.4) 0.0008* 9.10 (2.60–39.6) 0.0003*
Mean blood pressure ≤ 65 mmHg 1.29 (0.46–3.62) 0.79   
Use of catecholamine 0.86 (0.27–2.74) 1   
SOFA score ≥ 14 6.00 (1.67–21.6) 0.0075*   
APACHE II score ≥ 36 1.94 (0.65–5.85) 0.27   
Septic shock (Sepsis-3) 7.23 (2.23–23.4) 0.0008*   
Septic shock (Sepsis-1) 1.68 (0.59–4.82) 0.42   
  1. Values are expressed as median (interquartile range)
  2. The covariates in the multivariable-adjusted models were age ≥ 65 years, pre-hospital antimicrobial therapy, and lactate ≥ 2 mmol/L
  3. Abbreviations: CI confidence interval, CRRT continuous renal replacement therapy, PMX-DHP polymyxin B-immobilized fiber column direct hemoperfusion, AKI acute kidney injury, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation *P < 0.05