Using Sepsis-3 criteria to predict prognosis of patients receiving continuous renal replacement therapy for community-acquired sepsis: a retrospective observational study

Table 6 Relative risk of in-hospital mortality using univariate and multivariate logistic regression models

Variable	In-hospital mortality
	Univariate analysis		Multivariate analysis
	Odds ratio (95% CI)	P value	Odds ratio (95% CI)	P value
Age ≥ 65 years	3.93 (1.36–11.3)	0.012*	3.96 (1.22–14.3)	0.021*
Male sex	0.60 (0.20–1.77)	0.41
Hypertension	1.38 (0.51–3.77)	0.61
Diabetes	0.27 (0.07–1.10)	0.07
Smoking	1.44 (0.53–3.89)	0.61
Alcoholism	0.38 (0.07–2.07)	0.45
Positive cultures	0.47 (0.17–1.32)	0.2
Pre-hospital antimicrobial therapy	1.93 (0.71–5.27)	0.22	2.81 (0.85–10.6)	0.093
Operation before starting CRRT	0.76 (0.25–2.30)	0.78
PMX-DHP combination	1.44 (0.50–4.18)	0.59
AKI at the start of CRRT	0.43 (0.14–1.35)	0.16
Lactate ≥ 2 mmol/L	7.23 (2.23–23.4)	0.0008*	9.10 (2.60–39.6)	0.0003*
Mean blood pressure ≤ 65 mmHg	1.29 (0.46–3.62)	0.79
Use of catecholamine	0.86 (0.27–2.74)	1
SOFA score ≥ 14	6.00 (1.67–21.6)	0.0075*
APACHE II score ≥ 36	1.94 (0.65–5.85)	0.27
Septic shock (Sepsis-3)	7.23 (2.23–23.4)	0.0008*
Septic shock (Sepsis-1)	1.68 (0.59–4.82)	0.42

Values are expressed as median (interquartile range)
The covariates in the multivariable-adjusted models were age ≥ 65 years, pre-hospital antimicrobial therapy, and lactate ≥ 2 mmol/L
Abbreviations: CI confidence interval, CRRT continuous renal replacement therapy, PMX-DHP polymyxin B-immobilized fiber column direct hemoperfusion, AKI acute kidney injury, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation *P < 0.05

ISSN: 2059-1381