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Table 2 Effect of renal anemia by vitamin D therapy

From: Restoration of renal anemia following therapy with etelcalcetide for refractory secondary hyperparathyroidism: a case report with mini-review

References Albitar et al. [14] Goicoechea et al. [2] Capuano et al. [15] Matias et al. [16] Fusaro et al. [23]
Number of patients 12 (M 8, F 4) 28 12 (M 8, F 4) 158 (M 74, F 84) 5 (M 4, F 1)
Years old 59 ± 14 55.5 ± 17 40–85 62.8 ± 14.8 65.9 ± 14.11
Used drugs and initial doses Alfacalcidol 6.1 ± 1.5 mg/week Intravenous calcitriol 6μ/week Paricalcitol (iPTH/80)μg/week Paricalcitol 7.2 ± 4.5 μg/week Paricalcitol 15 ± 5 μg/week
Baseline iPTH (pg/mL) 475 811.6 ± 327 About 450 233 590 ± 165
Changed iPTH(pg/mL) 120 (3M)
210 (6M)
180 (12M)
471 ± 512 (3M)
550 ± 471 (12M)
About 250 (1Y) 208 (1Y) 478 ± 81 (1Y)
Baseline Hb (g/dL) 8.7 ± 1.2 10.7 ± 1.7 10.9 ± 0.5 12.1 ± 1.2 11.04 ± 1.39
Changed Hb (g/dL) 10.3 ± 0.8 (3M)
10.8 ± 0.9 (6M)
10.7 ± 0.9 (12M)
11.7 ± 1.5 (3M)
11.7 ± 1.5 (12M)
11.5 ± 0.6 (1Y) 11.9 ± 1.4 (1Y) 11.59 ± 1.38 (1Y)
Baseline ESA doses Not listed 103.4 ± 60 U/kg/week Epoetin α or β 13,930 ± 4088/week Darbepoetin 0.042 μg/kg/week/g/dL Darbepoetin 68 ± 10 μg/week
Changed ESA doses Not listed 104.5 ± 59.5 U/kg/week (3M)
109 ± 64 U/Kg/week (12M)
Epoetin α or β 11,758 ± 4084/week Darbepoetin 0.033 μg/kg/week/g/dL Darbepoetin 65 ± 16 μg/week
Baseline vitamin D doses Alfacalcidol 6.1 ± 1.5 mg/week Intravenous calcitriol 6μ/week Paricalcitol (iPTH/80)μg/week Paricalcitol 7.2 ± 4.5 μg/week Paricalcitol 15 ± 5 μg/week
Changed vitamin D doses Alfacalcidol 6.1 ± 1.5 mg/week Intravenous calcitriol 6μ/week Paricalcitol (iPTH/80)μg/week Paricalcitol 6.0 ± 4.1 μg/week Paricalcitol 15 ± 5 μg/week
  1. Changes in iPTH, Hb concentration, doses of ESA and doses of vitamin D during control and treatment periods. Values are expressed as mean ± SD or median
  2. P < 0.05: A value that recognizes a significant difference (p < 0.05) with respect to the value of base line
  3. (3M) vitamin D therapy 3 months
  4. (6M) vitamin D therapy 6 months
  5. (12M) vitamin D therapy 12 months
  6. (1Y) vitamin D therapy 1 year