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Table 2 Effect of renal anemia by vitamin D therapy

From: Restoration of renal anemia following therapy with etelcalcetide for refractory secondary hyperparathyroidism: a case report with mini-review

References

Albitar et al. [14]

Goicoechea et al. [2]

Capuano et al. [15]

Matias et al. [16]

Fusaro et al. [23]

Number of patients

12 (M 8, F 4)

28

12 (M 8, F 4)

158 (M 74, F 84)

5 (M 4, F 1)

Years old

59 ± 14

55.5 ± 17

40–85

62.8 ± 14.8

65.9 ± 14.11

Used drugs and initial doses

Alfacalcidol 6.1 ± 1.5 mg/week

Intravenous calcitriol 6μ/week

Paricalcitol (iPTH/80)μg/week

Paricalcitol 7.2 ± 4.5 μg/week

Paricalcitol 15 ± 5 μg/week

Baseline iPTH (pg/mL)

475

811.6 ± 327

About 450

233

590 ± 165

Changed iPTH(pg/mL)

120 (3M)

210 (6M)

180 (12M)

471 ± 512 (3M)

550 ± 471 (12M)

About 250 (1Y)

208 (1Y)

478 ± 81 (1Y)

Baseline Hb (g/dL)

8.7 ± 1.2

10.7 ± 1.7

10.9 ± 0.5

12.1 ± 1.2

11.04 ± 1.39

Changed Hb (g/dL)

10.3 ± 0.8 (3M)

10.8 ± 0.9 (6M)

10.7 ± 0.9 (12M)

11.7 ± 1.5 (3M)

11.7 ± 1.5 (12M)

11.5 ± 0.6 (1Y)

11.9 ± 1.4 (1Y)

11.59 ± 1.38 (1Y)

Baseline ESA doses

Not listed

103.4 ± 60 U/kg/week

Epoetin α or β 13,930 ± 4088/week

Darbepoetin 0.042 μg/kg/week/g/dL

Darbepoetin 68 ± 10 μg/week

Changed ESA doses

Not listed

104.5 ± 59.5 U/kg/week (3M)

109 ± 64 U/Kg/week (12M)

Epoetin α or β 11,758 ± 4084/week

Darbepoetin 0.033 μg/kg/week/g/dL

Darbepoetin 65 ± 16 μg/week

Baseline vitamin D doses

Alfacalcidol 6.1 ± 1.5 mg/week

Intravenous calcitriol 6μ/week

Paricalcitol (iPTH/80)μg/week

Paricalcitol 7.2 ± 4.5 μg/week

Paricalcitol 15 ± 5 μg/week

Changed vitamin D doses

Alfacalcidol 6.1 ± 1.5 mg/week

Intravenous calcitriol 6μ/week

Paricalcitol (iPTH/80)μg/week

Paricalcitol 6.0 ± 4.1 μg/week

Paricalcitol 15 ± 5 μg/week

  1. Changes in iPTH, Hb concentration, doses of ESA and doses of vitamin D during control and treatment periods. Values are expressed as mean ± SD or median
  2. P < 0.05: A value that recognizes a significant difference (p < 0.05) with respect to the value of base line
  3. (3M) vitamin D therapy 3 months
  4. (6M) vitamin D therapy 6 months
  5. (12M) vitamin D therapy 12 months
  6. (1Y) vitamin D therapy 1 year