・Renal insufficiency | |
・Hypercalcemia | |
・Hyperphosphatemia | |
・Hyperparathyroidism (both primary and secondary) | |
・Over-suppression of i-PTH with adynamic bone disease | |
・Vitamin K deficiency | |
・Female sex | |
・Obesity | |
・Diabetes mellitus | |
・Hypoalbuminemia | |
・Rapid weight loss | |
・Thrombophilia (e.g., antithrombin III deficiency, protein C deficiency, protein S deficiency, or lupus anticoagulant) | |
・Skin trauma (e.g., from subcutaneous injections) | |
・Medications (e.g., warfarin, VDRA, calcium carbonate, corticosteroids, and recombinant PTH) |