Fig. 2From: Effect of lactate as a peritoneal dialysis fluid buffer on rat peritoneal mesothelial cellsEffects of lactate on EMT of PMCs. Levels of mRNA expression for e-cadherin (a), αSMA (b), and MMP-2 (c) with each stimulus time: control group, L5 group, L10 group, L20 group, L40 group, L80 group, *P < 0.05 vs control group, **P < 0.01 vs control group. ***P < 0.001 vs control, #P < 0.0001 vs control group. Levels of mRNA expression for e-cadherin (d), αSMA (e), and MMP-2 (f) with each stimulus dose: 6 h, 24 h, 48 h, 72 h. *P < 0.05 vs 6 h. **P < 0.01 vs 6 h. ***P < 0.001 vs 6 h. #P < 0.0001 vs 6 h. E-cadherin mRNA decreased (a, d) and αSMA mRNA expression increased (b, e) depending on lactate dose and stimulation time. MMP2 mRNA expression was stimulated at 48 and 72 h with 80 mEq/L (c, f)Back to article page