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Table 2 Group characteristics based on target levels for low-molecular-weight protein removal according to complications

From: Glycated hemoglobin and glycated albumin in patients with diabetes undergoing hemodiafiltration

 Group A
Non-protein-leaking OHDF
Group B
Protein-leaking OHDF
Group C
Highly efficient protein-leaking OHDF
p value
Classification of albumin leakage≤ 2.0 g2.1 g ≥, < 6.06.0 g ≥
Albumin leakage (g)0.85 ± 0.603.45 ± 1.087.64 ± 1.36
Number of patients (M/F)20 (15/5)14 (12/2)7(7/0)
Age (years)75.0 ± 7.761.1 ± 8.857.6 ± 7.0< 0.0001
Dialysis history (months)67.7 ± 35.571.4 ± 52.096.0 ± 67.40.7176
Dialysis time (h)4.0 ± 0.33.9 ± 0.34.1 ± 0.20.7720
Blood flow rate (mL/min)221.1 ± 25.4262.9 ± 21.6257.1 ± 18.90.0011
Dialysate flow rate (mL/min)600600600
Replacement amount volume (L)59.5 ± 14.958.4 ± 10.165.7 ± 9.60.4695
Dry weight (kg)53.7 ± 9.370.4 ± 13.976.3 ± 10.9< 0.0001
Albumin (g/dL)3.3 ± 0.43.5 ± 0.33.3 ± 0.20.2272
UN (mg/dL)60.5 ± 17.257.2 ± 11.059.0 ± 14.50.7829
Hb (g/dL)10.2 ± 0.710.8 ± 1.610.7 ± 0.80.2394
Ht (%)30.4 ± 2.432.7 ± 4.332.2 ± 2.60.0799
Pre-dialysis blood glucose (mg/dL)131.1 ± 37.8119.7 ± 48.6133.8 ± 35.70.5783
HbA1c (%)6.0 ± 0.96.4 ± 0.96.3 ± 0.90.3197
GA (%)19.5 ± 2.618.4 ± 3.717.5 ± 4.50.2172
Fe (μg/dL)45.9 ± 27.659.7 ± 28.274.0 ± 53.20.3077
TIBC (μg/dL)211.3 ± 55.5244.6 ± 49.8243.7 ± 66.20.2961
TSAT (%)22.2 ± 12.524.8 ± 11.535.5 ± 30.30.6347
Ferritin (ng/dL)201.3 ± 183.4206.2 ± 283.8225.4 ± 206.60.9274
ESAs
 Darbepoetin alfa (μg/week) (number)21.3 ± 23.8 (11)20.4 ± 5.9 (3)3.8 ± 3.5 (2)
 Epoetin beta (U/week) (number)2437.5 (1)3937.5 (1)
 Epoetin beta pegol (μg/week) (number)23.8 ± 12.0 (5)18.8 ± 4.4 (5)37.5 (1)
ERI (each ESA dose/kg/g/dL/week)
 Darbepoetin alfa0.012 ± 0.0110.008 ± 0.0030.002 ± 0.001
 Epoetin beta4.26.3
 Epoetin beta pegol0.049 ± 0.0250.030 ± 0.0080.043
Iron (intravenous administration) (mg/week)
 Saccharated ferric oxide (number)65.0 ± 59.2 (4)50.0 ± 42.4 (2)
Iron-based phosphate binder (oral administration) (mg/week)
 Sucroferric oxyhydroxide (number)7000.0 ± 3031.1 (3)12250.0 ± 8019.5 (3)615.0 ± 1237.4 (2)
 Ferric citrate hydrate (number)10500.0 (2)22750 ± 6062.3 (3)15750 (2)
  1. Mean age, blood flow rate, and dry weight were all significantly different among the 3 groups. TSAT(%) = [serum Fe (μg/dL)/TIBC (μg/dL)] × 100. Levels are presented as mean ± standard deviation