Triple combination therapy with telmisartan, amlodipine, and hydrochlorothiazide ameliorates albuminuria in a normotensive rat remnant kidney model

Table 1 Characteristics of all groups 4 weeks after treatment

	Sham	NTx + CMC	NTx + T + A	NTx + T +A + H
Number	10	9	8	7
HR (/min)	381 ± 16	385 ± 17	399 ± 18	383 ± 19
Systolic BP (mmHg)	117 ± 4	115 ± 4	106 ± 5	108 ± 5
Body weight (g)	460 ± 11	430 ± 12	486 ± 13^#	442 ± 13
BUN (mg/dL)	16.2 ± 1.5	29.4 ± 1.6***	27.8 ± 0.7***	27.0 ± 1.8***
Na (mmol/L)	138 ± 2	142 ± 1	137 ± 2	134 ± 2^#
K (mmol/L)	5.84 ± 0.16	5.56 ± 0.17	5.05 ± 0.18**^,#	5.64 ± 0.19
Calcium (mg/dL)	9.88 ± 0.15	9.92 ± 0.16	9.82 ± 0.17	9.43 ± 0.18
Phosphate (mg/dL)	6.84 ± 0.24	7.16 ± 0.25	6.60 ± 0.27	6.97 ± 0.29
Urinary Na (nmol/day)	754 ± 57	680 ± 60	427 ± 64**	681 ± 68

Data are shown as mean ± SEM
Abbreviations: NTx nephrectomized, HR heart rate, CMC carboxymethylcellulose, T telmisartan, A amlodipine, H hydrochlorothiazide, BUN blood urea nitrogen, Na sodium, K potassium
**p < 0.01, ***p < 0.001 vs sham, ^#p < 0.05 vs NTx + CMC

ISSN: 2059-1381