Table 5 Evidence profile
Certainty assessment | Number of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of studies | Study design | Bias risk | Inconsistency | Indirectness | Inaccuracy | Other | Icodextrin dialysis solution | Glucose dialysis solution monotherapy | Relative [95% CI] | Absolute (95% CI) | ||
Overall survival rate (number of deaths due to events) | ||||||||||||
10 | RCT | Serious a | Not serious | Not serious | Serious b | None | 10/592 (1.7%) | 14/514 (2.7%) | RR 0.75 [0.33–1.71] | 7 patients decreased per 1000 patients (18 patients decreased to 19 patients increased) | ⨁⨁◯◯ Low | Critical |
Technical survival (PD continuation period/PD withdrawal) | ||||||||||||
5 | RCT | Serious a | Not serious | Not serious | Serious c | None | 10/239 (4.2%) | 17/231 (7.4%) | RR 0.57 [0.29–1.12」 | 32 patients decreased per 1000 patients (52 patients decreased to 9 patients increased) | ⨁⨁◯◯ Low | Critical |
Peritoneal clearance volume (episodes of poor body fluid management) | ||||||||||||
4 | RCT | Serious a | Not serious | Not serious | Not serious | None | 3/129 (2.3%) | 12/111 (10.8%) | RR 0.31 [0.12–0.82] | 73 patients decreased per 1000 patients (93 patients decreased to 19 patients decreased) | ⨁⨁⨁◯ Moderate | Critical |
Peritoneal clearance volume (total daily clearance) | ||||||||||||
6 | RCT | Serious a | Not serious | Not serious | Serious d | None | 133 | 119 | - | MD 186.76 mL increase (47.08 mL decrease to- 420.59 mL increase) | ⨁⨁◯◯ Low | Critical |
Urine volume | ||||||||||||
4 | RCT | Serious a | Not serious | Not serious | Serious d | None | 75 | 61 | - | MD 106.08 mL increase (173.29 mL decrease to 385.45 mL increase) | ⨁⨁◯◯ Low | Critical |
Residual renal function (GFR/CCr) | ||||||||||||
5 | RCT | Serious a | Not serious | Not serious | Not serious | None | 97 | 84 | - | MD 0.56 increase (0.37 decrease to 1.49 increase) | ⨁⨁⨁◯ Moderate | Critical |
Peritoneal function (creatinine level, etc.) (D/P Cr value) | ||||||||||||
2 | RCT | Serious a | Serious e | Not serious | Serious f | None | 55 | 50 | - | MD 0.00 (0.07 decrease to 0.07 increase) | ⨁◯◯◯ Very low | Important |
Complications (peritonitis) | ||||||||||||
8 | RCT | Serious a | Not serious | Not serious | Serious b | None | 128/551 (23.2%) | 108/483 (22.4%) | RR 0.95 [0.79–1.15] | 11 patients decreased per 1000 patients (47 patients decreased to 34 patients increased) | ⨁⨁◯◯ Low | Critical |
Complications (rash) | ||||||||||||
4 | RCT | Serious a | Not serious | Not serious | Serious c | None | 56/392 (14.3%) | 17/334 (5.1%) | RR 1.84 [0.48–7.09] | 43 patients increased per 1000 patients (26 patients decreased to 310 patients increased) | ⨁⨁◯◯ Low | Critical |
Occurrence rate of impaired glucose tolerance—not reported | ||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | Critical |