Peritoneal Dialysis Guidelines 2019 Part 2: Main Text (Position paper of the Japanese Society for Dialysis Therapy)

Table 7 Evidence profile: SR3.2. Comparison of mupirocin and gentamicin ointments

Certainty assessment							Number of patients		Effect		Certainty	Importance
No. of studies	Study design	Bias risk	Inconsistency	Indirectness	Inaccuracy	Other	Mupirocin ointment	Gentamicin ointment	Relative [95% CI]	Absolute (95% CI)	Certainty	Importance
Peritonitis
3	RCT	Serious ^{a, b}	Not serious	Not serious	Serious ^c	None	40/128 patient-years	43/133 patient-years	0.85 [0.32–2.26]	4.8 event decrease per 100 patients/year (22.0 decrease to 40.7 increase)	⨁⨁◯◯ Low	Critical
Technical survival
3	RCT	Serious ^{a, b}	Not serious	Not serious	Serious ^c	None	11/128 patient-years	22/133 patient-years	0.58 [0.28–1.20]	6.9 event decrease per 100 patients/year (11.9 decrease to 3.3 increase)	⨁⨁◯◯ Low	Critical
Exit site tunnel infection
2	RCT	Serious ^{a, b}	Serious ^d	Not serious	Serious ^c	None	78/99 patient-years	30/104 patient-years	1.14 [0.27–4.81]	4.0 event increase per 100 patients/year (21.1 decrease to 109.9 increase)	⨁◯◯◯ Very low	Critical
Exit site tunnel infection (excluding Chu (2008) [15])
1 ^e	RCT	Not serious	Not serious	Not serious	Not serious	None	29/54 patient-years	15/64 patient-years	2.31 [1.24–4.31]	30 event increase per 100 patients/year (5.6 increase to 77.2 increase)	⨁⨁⨁⨁ High	Critical
Complications (including drug adverse effects/safety issues/hospital stay period)—not reported
-	-	-	-	-	-	-	-	-	-	-	-	Critical

CI, confidence interval; RR, risk ratio
^aMany unclear elements
^bIncludes semi-RCTs (alternate allotment)
^cThe 1% difference appeared to be affected by selection of the intervention, and we determined that the 95% CI straddles the threshold
^dEffect directionality varies between studies
^eBecause the Chu (2008) [15] study was semi-random, we excluded it, performed a sensitivity analysis, and selected the clinically problematic outcome

ISSN: 2059-1381