Peritoneal Dialysis Guidelines 2019 Part 2: Main Text (Position paper of the Japanese Society for Dialysis Therapy)

Table 9 Evidence profile (effects of intravenous administration in comparison to intraperitoneal administration)

Certainty assessment							Number of patients		Effect		Certainty	Importance
No. of studies	Study design	Bias risk	Inconsistency	Indirectness	Inaccuracy	Other	Intra-venous	Intra-peritoneal	Relative [95% CI]	Absolute (95% CI)	Certainty	Importance
PD withdrawal (Primary treatment failure)
2	RCT	Serious ^a	Not serious	Not serious	Serious ^b	None	13/46 (28.3%)	4/49 (8.2%)	Cannot estimate	130 patients decreased per 1000 patients (430 patients decreased to 170 patients increased) (calculated using risk differences)	⨁⨁◯◯ Low	Critical
Complications (drug adverse events/safety)
2	RCT	Serious ^a	Not serious	Not serious	Serious ^b	None	4/47 (8.5%)	0/49 (0.0%)	RR 5.13 [0.63–41.59]	No change per 1000 patients	⨁⨁◯◯ Low	Critical
Complications (Infusion pain, vascular leakage of vancomycin) (see Note e)
1	RCT	Serious ^a	Not serious	Very serious ^c	Very serious ^d	None	1/10 (10.0%)	0/10 (0.0%)	RR 3.00 [0.14–65.90]	No change per 1000 patients
Peritonitis successfully treated—not reported
-	-	-	-	-	-	-	-	-	-	-	-	Critical
Time till peritonitis successfully treated—not reported
-	-	-	-	-	-	-	-	-	-	-	-	Critical
Reoccurrence of peritonitis—not reported
-	-	-	-	-	-	-	-	-	-	-	-	Critical

CI, confidence interval; RR, risk ratio
^aMany unclear elements, including randomization and concealment
^bStraddles clinical threshold
^cComplication of vascular leakage; different from pain during injection
^dStraddles clinical threshold and not enough cases
^eOnly one case involved vascular leakage of vancomycin, so we included it only as a reference

ISSN: 2059-1381