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Table 3 PTA of all recommended imipenem dosing regimens for Pseudomonas aeruginosa infections in CVVHD modality with 25 and 35 mL/kg/h effluent rates

From: Imipenem dosing recommendations for patients undergoing continuous renal replacement therapy: systematic review and Monte Carlo simulations

Dosage regimens Probability of target attainment over 48 h, MIC of 2 mg/L
Effluent rates 25 mL/kg/h Effluent rates 35 mL/kg/h
40% fT > MIC 40% fT > 4MIC 100% fT > MIC 40% fT > MIC 40% fT > 4MIC 100% fT > MIC
500 mg q 8 h* 1 0.1970 0.0408 0.9992 0.1318 0.0196
750 mg q 12 h* 0.9864 0.1340 0.0238 0.9734 0.0674 0.0096
500 mg q 6 h* 1 0.5812 0.1484 0.9998 0.4710 0.1182
1000 mg LD 500 mg q 8 h* 1 0.3434 0.2676 0.9994 0.2490 0.1910
1000 mg LD 500 mg q 6 h* 1 0.7230 0.5804 1 0.6152 0.4968
750 mg q 6 h 1 0.9388 0.4668 1 0.9052 0.4234
1000 mg q 8 h 1 0.9214 0.4926 1 0.8700 0.4112
2000 mg q 12 h 0.9988 0.9408 0.4906 0.9976 0.9000 0.4010
1500 mg q 8 h 1 0.9966 0.7700 1 0.9948 0.7128
1500 mg q 6 h 1 1 0.9016 1 0.9992 0.8826
2000 mg LD then 1500 mg q 6 h 1 1 0.9500 1 0.9996 0.9402
2500 mg q 8 h 1 0.9998 0.9254 1 1 0.8872
3000 mg LD then 2500 mg q 8 h 1 0.9998 0.9322 1 1 0.9138
16,000 mg q 12 h 1 0.9998 0.9036 1 0.9998 0.8862
22,000 mg q 12 h 1 0.9998 0.9330 1 0.9998 0.9058
  1. PTA probability of target attainment, CVVHD continuous venovenous hemodialysis, LD loading dose
  2. *Literature based regimens