Table 3 PTA of all recommended imipenem dosing regimens for Pseudomonas aeruginosa infections in CVVHD modality with 25 and 35 mL/kg/h effluent rates
Dosage regimens | Probability of target attainment over 48 h, MIC of 2 mg/L | |||||
|---|---|---|---|---|---|---|
Effluent rates 25 mL/kg/h | Effluent rates 35 mL/kg/h | |||||
40% fT > MIC | 40% fT > 4MIC | 100% fT > MIC | 40% fT > MIC | 40% fT > 4MIC | 100% fT > MIC | |
500 mg q 8 h* | 1 | 0.1970 | 0.0408 | 0.9992 | 0.1318 | 0.0196 |
750 mg q 12 h* | 0.9864 | 0.1340 | 0.0238 | 0.9734 | 0.0674 | 0.0096 |
500 mg q 6 h* | 1 | 0.5812 | 0.1484 | 0.9998 | 0.4710 | 0.1182 |
1000 mg LD 500 mg q 8 h* | 1 | 0.3434 | 0.2676 | 0.9994 | 0.2490 | 0.1910 |
1000 mg LD 500 mg q 6 h* | 1 | 0.7230 | 0.5804 | 1 | 0.6152 | 0.4968 |
750 mg q 6 h | 1 | 0.9388 | 0.4668 | 1 | 0.9052 | 0.4234 |
1000 mg q 8 h | 1 | 0.9214 | 0.4926 | 1 | 0.8700 | 0.4112 |
2000 mg q 12 h | 0.9988 | 0.9408 | 0.4906 | 0.9976 | 0.9000 | 0.4010 |
1500 mg q 8 h | 1 | 0.9966 | 0.7700 | 1 | 0.9948 | 0.7128 |
1500 mg q 6 h | 1 | 1 | 0.9016 | 1 | 0.9992 | 0.8826 |
2000 mg LD then 1500 mg q 6 h | 1 | 1 | 0.9500 | 1 | 0.9996 | 0.9402 |
2500 mg q 8 h | 1 | 0.9998 | 0.9254 | 1 | 1 | 0.8872 |
3000 mg LD then 2500 mg q 8 h | 1 | 0.9998 | 0.9322 | 1 | 1 | 0.9138 |
16,000 mg q 12 h | 1 | 0.9998 | 0.9036 | 1 | 0.9998 | 0.8862 |
22,000 mg q 12 h | 1 | 0.9998 | 0.9330 | 1 | 0.9998 | 0.9058 |