Table 4 Changes in chronic kidney disease—mineral and bone disorder-related parameters (effectiveness-analysis set)

Serum phosphate [mg/dL]

 Patients with heart failure

  HD

n

146

127

112

77

83

77

64

59

Absolute value, mean (SD)

6.73 (1.45)

5.69 (1.52)

5.34 (1.36)

5.16 (1.32)

5.19 (1.27)

5.09 (1.17)

5.04 (1.27)

5.09 (1.22)

n

127

112

77

83

77

64

59

Change from baseline, mean (SD)

 − 1.10 (1.38)

 − 1.36 (1.47)

 − 1.55 (1.51)

 − 1.40 (1.55)

 − 1.46 (1.56)

 − 1.55 (1.90)

 − 1.55 (1.62)

  PD

n

33

31

27

17

22

18

12

9

Absolute value, mean (SD)

6.62 (1.36)

5.96 (1.42)

5.53 (1.49)

5.21 (0.72)

5.62 (1.54)

5.71 (1.58)

5.03 (1.42)

5.34 (1.95)

31

27

17

22

18

12

9

Change from baseline, mean (SD)

 − 0.61 (1.13)

 − 1.09 (1.42)

 − 1.24 (1.31)

 − 1.03 (1.43)

 − 0.84 (1.15)

 − 1.47 (1.40)

 − 1.31 (1.13)

  ND

n

124

103

85

71

74

59

32

44

Absolute value, mean (SD)

5.33 (1.09)

4.92 (1.18)

4.74 (1.03)

4.60 (1.09)

4.74 (1.26)

4.79 (1.13)

4.91 (1.25)

4.70 (1.05)

n

103

85

71

74

59

32

44

Change from baseline, mean (SD)

 − 0.44 (1.00)

 − 0.49 (0.91)

 − 0.49 (1.26)

 − 0.34 (1.24)

 − 0.22 (1.16)

 − 0.07 (1.34)

 − 0.23 (1.09)

 Patients without heart failure

  HD

n

1223

1012

945

810

850

798

674

631

Absolute value, mean (SD)

6.56 (1.38)

5.82 (1.45)

5.57 (1.45)

5.31 (1.35)

5.39 (1.41)

5.35 (1.34)

5.43 (1.27)

5.40 (1.31)

n

1011

940

806

847

793

671

627

Change from baseline, mean (SD)

 − 0.76 (1.48)

 − 0.96 (1.54)

 − 1.17 (1.61)

 − 1.14 (1.70)

 − 1.18 (1.63)

 − 1.13 (1.62)

 − 1.17 (1.62)

  PD

n

144

125

106

88

89

77

63

53

Absolute value, mean (SD)

6.06 (1.35)

5.51 (1.16)

5.39 (1.43)

5.42 (1.52)

5.27 (1.17)

5.27 (1.02)

5.26 (1.10)

5.10 (1.16)

n

125

106

88

89

77

63

53

Change from baseline, mean (SD)

 − 0.58 (1.32)

 − 0.72 (1.40)

 − 0.74 (1.53)

 − 0.69 (1.46)

 − 0.77 (1.48)

 − 0.80 (1.49)

 − 1.06 (1.72)

  ND

n

657

499

399

308

312

249

181

149

Absolute value, mean (SD)

5.34 (1.03)

4.95 (1.13)

4.78 (1.12)

4.84 (1.21)

4.90 (1.26)

4.82 (1.22)

4.88 (1.27)

4.90 (1.19)

n

499

398

307

312

248

181

149

Change from baseline, mean (SD)

 − 0.44 (0.99)

 − 0.51 (1.10)

 − 0.37(1.16)

 − 0.23 (1.27)

 − 0.27 (1.19)

 − 0.16 (1.22)

 − 0.16 (1.22)

Corrected Ca [mg/dL]

 Patients with heart failure

  HD

n

146

127

112

77

83

77

64

59

Absolute value, mean (SD)

8.55 (0.77)

8.66 (0.68)

8.68 (0.75)

8.65 (0.73)

8.57 (0.79)

8.69 (0.64)

8.64 (0.66)

8.66 (0.72)

n

127

112

77

83

77

64

59

Change from baseline, mean (SD)

0.12 (0.63)

0.14 (0.78)

0.10 (0.81)

0.02 (0.91)

0.23 (0.80)

0.14 (0.81)

0.15 (0.75)

  PD

n

33

31

27

17

22

18

12

9

Absolute value, mean (SD)

8.25 (0.80)

8.37 (0.66)

8.61 (0.66)

8.49 (0.67)

8.54 (0.70)

8.23 (0.73)

8.51 (0.86)

8.46 (0.68)

n

31

27

17

22

18

12

9

Change from baseline, mean (SD)

0.05 (0.65)

0.25 (0.70)

0.09 (0.87)

0.20 (0.96)

 − 0.25 (0.88)

0.27 (1.22)

0.17 (1.21)

  ND

n

122

103

84

70

73

59

32

44

Absolute value, mean (SD)

8.38 (0.69)

8.49 (0.69)

8.57 (0.67)

8.49 (0.74)

8.48 (0.72)

8.61 (0.81)

8.72 (0.61)

8.63 (0.72)

n

102

84

69

72

59

32

44

Change from baseline, mean (SD)

0.12 (0.46)

0.16 (0.53)

0.04 (0.62)

 − 0.02(0.60)

0.13 (0.70)

0.25 (0.67)

0.02 (0.70)

 Patients without heart failure

  HD

n

1222

1010

943

809

850

798

672

631

Absolute value, mean (SD)

8.73 (0.81)

8.76 (0.75)

8.78 (0.72)

8.80 (0.70)

8.76 (0.75)

8.77 (0.73)

8.75 (0.67)

8.74 (0.70)

n

1009

938

806

847

793

669

627

Change from baseline, mean (SD)

0.04 (0.68)

0.09 (0.74)

0.11 (0.85)

0.05 (0.90)

0.07 (0.86)

0.05 (0.90)

0.01 (0.90)

  PD

n

142

123

106

88

89

77

63

55

Absolute value, mean (SD)

8.5 (0.78)

8.57 (0.67)

8.54 (0.69)

8.59 (0.78)

8.6 (0.72)

8.64 (0.77)

8.54 (0.63)

8.55 (0.73)

n

123

106

88

88

77

63

55

Change from baseline, mean (SD)

0.10 (0.55)

0.04 (0.67)

0.09 (0.81)

0.09 (0.85)

0.14 (0.91)

 − 0.03 (0.85)

0.00 (1.02)

  ND

n

656

500

399

309

312

249

181

148

Absolute value, mean (SD)

8.56 (0.80)

8.60 (0.77)

8.62 (0.96)

8.62 (0.72)

8.66 (0.79)

8.75 (0.68)

8.73 (0.77)

8.78 (0.71)

n

499

398

307

312

248

181

148

Change from baseline, mean (SD)

0.05 (0.60)

0.04 (0.79)

 − 0.01 (0.68)

 − 0.01 (0.75)

0.02 (0.70)

 − 0.05 (0.91)

0.02 (0.92)

Intact PTH [pg/mL]

 Patients with heart failure

  HD

n

104

66

70

44

57

54

51

44

Absolute value, median (IQR)

158.00 (99.00, 269.50)

149.50 (98.00, 238.00)

134.00 (77.00, 216.00)

179.50 (90.50, 258.00)

142.00 (70.00, 237.00)

136.50 (86.00, 214.00)

119.00 (79.00, 206.00)

108.50 (66.50, 177.00)

n

54

63

40

51

48

42

37

Change from baseline, median (IQR)

 − 17.00 (− 69.00, 1.00)

 − 22.00 (− 82.00, 14.00)

 − 1.00 (− 56.50, 77.50)

 − 12.00 (− 127.00, 40.00)

 − 17.00 (− 116.00, 27.50)

 − 15.00 (− 94.00, 43.00)

 − 26.00 (− 104.00, 17.00)

  PD

n

26

22

19

15

17

15

11

8

Absolute value, median (IQR)

171.00 (110.00, 339.00)

199.50 (89.00, 313.00)

163.00 (59.00, 228.00)

107.00 (52.00, 284.00)

194.00 (87.00, 259.00)

194.00 (89.00, 231.00)

137.00 (114.00, 230.00)

164.50 (122.00, 194.50)

n

20

18

13

16

14

9

6

Change from baseline, median (IQR)

 − 12.00 (− 61.00, 30.00)

 − 34.00 (− 136.00, 5.00)

0.00 (− 25.00, 11.00)

 − 12.00 (− 171.00, 53.50)

 − 9.00 (− 89.00, 37.00)

 − 13.00 (− 315.00, 4.00)

29.50 (− 79.00, 73.00)

  ND

n

63

41

46

44

46

38

17

32

Absolute value, median (SD)

194.00 (106.00, 296.00)

194.00 (112.00, 265.00)

148.00 (106.00, 219.00)

157.00 (105.50, 256.50)

187.50 (122.00, 290.00)

148.00 (85.00, 229.00)

162.00 (96.00, 198.00)

167.00 (99.50, 222.00)

n

30

40

31

32

26

7

22

Change from baseline, median (IQR)

 − 11.50 (− 85.00, 30.00)

 − 14.50 (− 47.50, 7.00)

 − 26.00 (− 76.00, 14.00)

 − 24.00 (− 57.00, 29.00)

 − 5.50 (− 59.00, 32.00)

 − 66.00 (− 89.00, − 10.00)

20.50 (− 5.00, 39.00)

 Patients without heart failure

  HD

n

878

555

579

480

544

552

512

487

Absolute value, median (IQR)

177.00 (106.00, 267.00)

163.00 (95.00, 245.00)

150.00 (92.00, 237.00)

144.00 (85.50, 214.00)

145.00 (92.50, 218.50)

145.50 (97.00, 222.50)

158.00 (92.00, 233.00)

154.00 (90.00, 220.00)

n

465

525

439

473

482

442

416

Change from baseline, median (IQR)

 − 10.00 (− 58.00, 25.00)

 − 13.00 (− 66.00, 29.00)

 − 15.00 (− 81.00, 38.00)

 − 12.00 (− 95.00, 40.00)

 − 13.00 (− 88.00, 38.00)

 − 9.50 (− 97.00, 45.00)

 − 11.50 (− 105.00, 50.50)

  PD

n

94

67

61

61

51

48

42

38

Absolute value, median (IQR)

193.50 (102.00, 371.00)

186.00 (86.00, 294.00)

177.00 (91.00, 318.00)

199.00 (102.00, 341.00)

167.00 (83.00, 249.00)

164.00 (80.00, 277.5)

195.00 (91.00, 329.00)

143.00 (83.00, 213.00)

n

62

54

53

41

41

34

31

Change from baseline, median (IQR)

 − 7.00 (− 60.00, 29.00)

9.00 (− 69.00, 52.00)

13.00 (− 90.00, 86.00)

2.00 (− 129.00, 90.00)

 − 1.00 (− 118.00, 94.00)

5.00 (− 169.00, 145.00)

 − 18.0 (− 234.00, 106.00)

  ND

n

261

167

148

127

135

106

86

71

Absolute value, median (SD)

228.00 (117.00, 373.00)

215.00 (121.00, 350.00)

210.00 (116.00, 337.50)

233.00 (122.00, 363.00)

211.00 (101.00, 367.00)

201.00 (100.00, 330.00)

193.50 (114.00, 295.00)

154.00 (98.00, 290.00)

n

119

109

84

79

63

45

40

Change from baseline, median (IQR)

 − 8.00 (− 38.00, 31.00)

4.00 (− 44.00, 38.00)

18.00 (− 42.00, 58.00)

1.00 (− 43.00, 47.00)

14.00 (− 42.00, 76.00)

6.00 (− 56.00, 63.00)

 − 7.00 (− 92.00, 56.00)