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Table 2 A review of past cases and our case on drug susceptibility and clinical features of M. mageritense-infected cases

From: Fatal peritoneal dialysis-associated peritonitis caused by Mycobacterium mageritense: a case report with review

 

Present case

Case 1

Case 2

Case 3

Case 4

Case 5

 

Age

60’s

40’s

66

77

5

44

 

Sex

Male

Male

Male

Male

Girl

Female

 

Underlying condition

ESKD on peritoneal dialysis

None specified

None specified

COPD, CAD

Acute encephalopathy, adrenal insufficiency

Breast cancer

 

Site of infection

Skin and peritoneum

Parotid gland

Prosthetic joint

Pleura

Soft tissue

Soft tissue and CVP

 

MIC (μg/mL)

      

Breakpoint of resistance (μg/mL)

 IPM

 < 0.5

1

4

 < 0.5

0.5

 < 2

 ≥ 32

 AMK

2

 > 64

8

4

32

 < 8

 ≥ 64

 CAM

0.25

N/A

 > 32

16

 > 512

 > 8

 ≥ 8

 TOB

4

N/A

N/A

 > 16

 > 16

N/A

 ≥ 8

 LZD

1

2

 < 1

 < 4

8

 < 4

 ≥ 32

 CPFX

 < 0.12

0.5

32

 < 0.5

0.25

1

 ≥ 4

 MFLX

 < 0.06

N/A

 < 0.25

 < 0.25

0.19

 < 1

 ≥ 4

 MINO

0.5

N/A

 < 1

2

4

N/A

 ≥ 8

 ST

 < 0.25/4.3

2

1/19

 < 2

 > 80

 > 4

 ≥ 4/76

Antibiotics

IPM

LVFX

CPFX

IPM

Tosufloxacin

AMK

 
 

AMK

ST

ST

LVFX

LZD

CPFX

 
 

CAM

 

AMK

    
   

IPM

    

Surgical intervention

Catheter removal

Parotid gland excision

Prosthetic joint explantation

Pleural fluid drainage

Abscess drainage

CVP removal and debridement

 

Outcome

Death due to peritonitis

Cured

Cured

Death due to aspiration pneumonia

Cured

Cured

 

Reference number

Present case

[5]

[6]

[7]

[8]

[9]

 
  1. Breakpoint of resistance values was based on those provided by Woods et al. [10]
  2. MIC, Minimal inhibitory concentration; ESKD, End-stage kidney disease; IPM, Imipenem; AMK, Amikacin; CAM, Clarithromycin; TOB, Tobramycin; LZD, Linezolid; CPFX, Ciprofloxacin; MFLX, Moxifloxacin; MINO, Minomycin; ST, Trimethoprim-sulfamethoxazole; LVFX, Levofloxacin; COPD, Chronic obstructive pulmonary disease; CAD, Coronary artery disease; CVP, Central venous port