Table 2 Previous reports of HAM after organ transplantation and HAM-mimicking myelitis after allo-HSCT
References | Year | HAM | Recipient after OTP | Development of HAM | Age, sex | Transplantation | Recipient HTLV-1 | Donor HTLV-1 | Recipient HTLV-1 after organ transplantation | HTLV-1 DNA | Neopterin | Immune suppression | Donor cells | Therapy | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HTLV-1-positive cohort after organ transplantation | |||||||||||||||
Yamauchi and Yamano et al. [7] | 2019 (99 HTLV-1-positive renal transplantation cohort in Japan) | HAM (4 cases) | + | 3.8 years (range, 1.3 to 8.4) | n.d | RTP | – | + | + | n.d | n.d | n.d | n.d | n.d | n.d |
RTP | – | + | + | ||||||||||||
RTP | – | + | + | ||||||||||||
RTP | – | + | + | ||||||||||||
Case report | |||||||||||||||
Nagamine et al. [22] | 2014 | HAM | + | 2 months | 38, F | RTP | – | + | + | 15/1000(PB) | 51 | FK/MMF | CD4 + :54% | IFNα | Imp |
Ramanan et al. [23] | 2014 | HAM | + | 5 months | 56, M | RTP | – | + | + | n.d | n.d | FK/MMF PSL | n.d | PSL AZT | Imp |
Inose et al. [26] | 2010 | HAM | + | 10 months | 51, M | RTP | – | n.e | + | 7.4% | n.d | CY/PSL | n.d | IFNα | Imp |
Kuroki et al. [27] | 2007 | HAM | n.e | 17 months | 40, M | RTP | n.e | n.e | n.e | 0.83% | n.d | CY/MMF/PSL | n.d | PSL | Imp |
Toro et al. [28] Imirizaldu et al. [29] | 2003 | HAM | + | 24 months | 54, F | RTP | – | + | + | 12.44% (164.4/1000) | n.d | CY | n.d | PSL | PD |
Toro et al. [28] Imirizaldu et al. [29] | 2003 | HAM | + | 20 months | 57, M | RTP | – | + | + | 16.44% (124.4/1000) | n.d | CY | n.d | PSL | PD |
Narukawa et al. [33] | 2001 | HAM | + | < 1 year | 48, M | RTP | n.e | n.e | + | n.d | 121 | n.d | n.d | PE | Imp |
Shintani et al. [30] | 2001 | HAM | + | 7 years | 56, M | RTP | n.e | n.e | + | n.d | n.d | n.d | n.d | PSL | n.d |
Nakatsuji et al. [24] | 2010 | HAM | + | 4 years | 50, M | RTP | – | n.e | + | n.d | n.d | CY/MMF/PSL | n.d | n.d | n.d |
Kuroda et al. [25] | 1992 | HAM | + | 11 months | 32, M | RTP | n.e | + | + | n.d | n.d | CY/MZR PSL.AZA | n.d | PSL | Imp |
Soyama et al. [31] | 2008 | HAM | + | 20 months | 58, M | Liver TRP | + | + | + | 180/1000 | n.d | TAC/PSL | n.d | IFNα ribavium | unchange |
Toro et al. [28] Imirizaldu et al. [29] | 2003 | HAM | + | 18 months | 44, F | Liver TRP | – | + | + | + | n.d | TAC | n.d | PSL IFNα | SD |
Ozden et al. [32] | 2001 | HAM | + | 5 months | 41, M | Heart TRP | – | – | + | n.d | n.d | n.d | n.d | PSL | Imp |
Kawamata et al. [21] | 2014 | HAM-mimicking myelitis | – | 20 months | 63, F | BMT | + | – | – | – | 8 | CSP | CD4 + CXCR3 + CCR4 + | mPSL | Imp |
Kawano et al. [3] | 2017 | Atypical HAM | – | 5 months | 46, F | BMT | + | – | – | 10.8 copies/1000 cells) | 95 | FK + sMTx → CSP | CD4 + XCR3 + partially CCR4 + | mPSL | Imp |
Yamauchi and Yamano et al. [7] | 2019 | HAM (1 case) | – | 8.3 | n.d | RTP | + | – | – | n.d | n.d | n.d | n.d | n.d | n.d |