Comparison of survival for super high-flux hemodialysis (SHF-HD) with high albumin leakage versus online hemodiafiltration or SHF-HD with low albumin leakage: the SUPERB study

Table 1 Comparison of variables before and after propensity score matching between SHF-HD with high EAL and OHDF with low EAL

Item	Before matching			After matching
Item	SHF-HD	OHDF	P-value	SHF-HD	OHDF	P-value
(a) SHF-HD with EAL at the third quartile or above vs. OHDF with EAL within the first quartile
n	117	127		117	117
Sex, male/female, %	71.7/28.3	61.4/38.6	0.104	71.8/28.2	59.8/40.2	0.073
Diabetes mellitus, % with/without	39.3/60.7	40.2/59.8	0.897	39.3/60.7	41.0/59.0	0.894
Age, years	68.5 ± 10.3	70.4 ± 10.0	0.199	68.5 ± 10.3	70,2 ± 9.8	0.279
Dialysis vintage, months	108.5 ± 90.9	133.5 ± 126.4	0.292	108.5 ± 90.9	135.9 ± 128.6	0.247
Body mass index, kg/m²	22.6 ± 4.2	22.1 ± 3.7	0.407	22.6 ± 4.2	22.2 ± 3.8	0.475
Normalized protein catabolism rate, g/kg/day	0.8 ± 0.2	0.8 ± 0.2	0.688	0.8 ± 0.2	0.8 ± 0.2	0.626
Albumin, g/dL	3.4 ± 0.3	3.4 ± 0.3	0.836	3.4 ± 0.3	3.4 ± 0.3	0.836
Corrected calcium, mg/dL	9.1 ± 0.7	9.2 ± 0.6	0.278	9.1 ± 0.7	9.2 ± 0.6	0.364
Phosphorus, mg/dL	5.1 ± 1.5	5.2 ± 1.4	0.381	5.1 ± 1.5	5.2 ± 1.3	0.518
Hemoglobin, g/dL	11.2 ± 1.2	10.8 ± 1.1	0.031	11.2 ± 1.2	10.9 ± 1.1	0.042
High-sensitivity C-reactive protein, mg/dL	0.337 ± 0.617	0.403 ± 1.199	0.122	0.337 ± 0.617	0.415 ± 1.242	0.168
Kt/V value	1.66 ± 0.28	1.60 ± 0.29	0.065	1.66 ± 0.28	1.61 ± 0.29	0.090
Systolic blood pressure, mmHg, predialysis	145 ± 21	140 ± 26	0.140	145 ± 21	140 ± 26	0.153
Blood flow rate, mL/min	275.7 ± 15.7	272.3 ± 17.3	0.139	275.7 ± 15.7	272.9 ± 17.4	0.253
Membrane surface area, m²	2.17 ± 0.15	2.24 ± 0.19	0.003	2.17 ± 0.15	2.23 ± 0.19	0.007

Variable	Before matching			After matching
Variable	SHF-HD	OHDF	P-value	SHF-HD	OHDF	P-value
(b) SHF-HD with EAL at or above the seventh octile vs. OHDF with EAL within the first octile
n	72	83		52	52
Sex, male/female, %	75.0/25.0	59.0/41.0	0.042	69.2/30.8	55.7/44.3	0.224
Diabetes mellitus, % with/without	41.7/58.3	34.9/65.1	0.411	42.3/57.7	46.2/53.8	0.844
Age, years	66.4 ± 10.9	72.4 ± 9.5	0.001	67.9 ± 10.1	71.3 ± 10.2	0.084
Dialysis vintage, months	111.1 ± 95.8	150.5 ± 138.3	0.129	112.9 ± 96.5	106.8 ± 104.8	0.723
Body mass index, kg/m²	23.3 ± 4.4	21.1 ± 3.0	0.002	23.0 ± 4.6	21.6 ± 3.1	0.298
Normalized protein catabolism rate, g/kg/day	0.8 ± 0.2	0.9 ± 0.2	0.563	0.8 ± 0.2	0.8 ± 0.2	0.777
Albumin, g/dL	3.4 ± 0.2	3.4 ± 0.3	0.917	3.5 ± 0.2	3.4 ± 0.3	0.930
Corrected calcium, mg/dL	9.1 ± 0.6	9.3 ± 0.6	0.069	9.1 ± 0.6	9.2 ± 0.7	0.358
Phosphorus, mg/dL	5.2 ± 1.5	5.2 ± 1.2	0.839	5.1 ± 1.2	5.2 ± 1.1	0.904
Hemoglobin, g/dL	11.2 ± 1.2	10.8 ± 1.1	0.025	11.2 ± 1.1	10.8 ± 1.0	0.077
High-sensitive C-reactive protein, mg/dL	0.337 ± 0.643	0.229 ± 0.403	0.117	0.236 ± 0.300	0.211 ± 0.289	0.483
Kt/V value	1.64 ± 0.26	1.63 ± 0.26	0.785	1.66 ± 0.27	1.65 ± 0.26	0.805
Systolic blood pressure, mm Hg, predialysis	147 ± 22	139 ± 25	0.082	144 ± 21	143 ± 25	0.876
Blood flow rate, mL/min	275.7 ± 17.9	274.8 ± 14.7	0.612	273.9 ± 17.5	275.2 ± 14.2	0.774
Membrane surface area, m²	2.22 ± 0.18	2.10 ± 0	< 0.001	2.12 ± 0.09	2.10 ± 0.0	0.080

EAL estimated albumin leakage; OHDF online hemodiafiltration; SHF-HD super high-flux hemodialysis

ISSN: 2059-1381